Conducting an Oral Food Challenge: An Update to the 2009 Adverse Reactions to Foods Committee Work Group Report

Nowak-Wegrzyn, 2009, Work Group report: oral food challenge testing, J Allergy Clin Immunol, 123, S365, 10.1016/j.jaci.2009.03.042 Akuete, 2017, Multicenter prevalence of anaphylaxis in clinic-based oral food challenges, Ann Allergy Asthma Immunol, 119, 339, 10.1016/j.anai.2017.07.028 Bindslev-Jensen, 2004, Standardization of food challenges in patients with immediate reactions to foods--position paper from the European Academy of Allergology and Clinical Immunology, Allergy, 59, 690, 10.1111/j.1398-9995.2004.00466.x Sampson, 2012, Standardizing double-blind, placebo-controlled oral food challenges: American Academy of Allergy, Asthma & Immunology-European Academy of Allergy and Clinical Immunology PRACTALL consensus report, J Allergy Clin Immunol, 130, 1260, 10.1016/j.jaci.2012.10.017 Turner, 2017, Fatal anaphylaxis: mortality rate and risk factors, J Allergy Clin Immunol Pract, 5, 1169, 10.1016/j.jaip.2017.06.031 Wallace, 2008, The diagnosis and management of rhinitis: an updated practice parameter, J Allergy Clin Immunol, 122, S1, 10.1016/j.jaci.2008.06.003 Bernstein, 2008, Allergy diagnostic testing: an updated practice parameter, Ann Allergy Asthma Immunol, 100, S1 Shah, 2010, Predicting which medication classes interfere with allergy skin testing, Allergy Asthma Proc, 31, 477, 10.2500/aap.2010.31.3382 Untersmayr, 2007, Incomplete digestion of codfish represents a risk factor for anaphylaxis in patients with allergy, J Allergy Clin Immunol, 119, 711, 10.1016/j.jaci.2006.10.039 Crapo, 2000, Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999, Am J Respir Crit Care Med, 161, 309, 10.1164/ajrccm.161.1.ats11-99 Kowalski, 2016, Risk and safety requirements for diagnostic and therapeutic procedures in allergology: World Allergy Organization Statement, World Allergy Organ J, 9, 33, 10.1186/s40413-016-0122-3 Toogood, 1988, Risk of anaphylaxis in patients receiving beta-blocker drugs, J Allergy Clin Immunol, 81, 1, 10.1016/0091-6749(88)90212-6 Matsumura, 1976, Hypersensitivity to histamine and systemic anaphylaxis in mice with pharmacologic beta adrenergic blockade: protection by nucleotides, J Allergy Clin Immunol, 58, 387, 10.1016/0091-6749(76)90119-6 Javeed, 1996, Refractory anaphylactoid shock potentiated by beta-blockers, Cathet Cardiovasc Diagn, 39, 383, 10.1002/(SICI)1097-0304(199612)39:4<383::AID-CCD13>3.0.CO;2-E Jacobs, 1981, Potentiated anaphylaxis in patients with drug-induced beta-adrenergic blockade, J Allergy Clin Immunol, 68, 125, 10.1016/0091-6749(81)90170-6 Newman, 1981, Epinephrine-resistant anaphylaxis in a patient taking propranolol hydrochloride, Ann Allergy, 47, 35 Lieberman, 2010, The diagnosis and management of anaphylaxis practice parameter: 2010 update, J Allergy Clin Immunol, 126, 477, 10.1016/j.jaci.2010.06.022 Rueff, 2009, Predictors of severe systemic anaphylactic reactions in patients with Hymenoptera venom allergy: importance of baseline serum tryptase—a study of the European Academy of Allergology and Clinical Immunology Interest Group on Insect Venom Hypersensitivity, J Allergy Clin Immunol, 124, 1047, 10.1016/j.jaci.2009.08.027 Corren, 2008, Allergen skin tests and free IgE levels during reduction and cessation of omalizumab therapy, J Allergy Clin Immunol, 121, 506, 10.1016/j.jaci.2007.11.026 Mizuma, 2015, Influence of omalizumab on allergen-specific IgE in patients with adult asthma, Int Arch Allergy Immunol, 168, 165, 10.1159/000442668 Sampson, 2011, A phase II, randomized, double-blind, parallel-group, placebo-controlled oral food challenge trial of Xolair (omalizumab) in peanut allergy, J Allergy Clin Immunol, 127, 1309, 10.1016/j.jaci.2011.01.051 Untersmayr, 2006, The effect of gastric digestion on food allergy, Curr Opin Allergy Clin Immunol, 6, 214, 10.1097/01.all.0000225163.06016.93 Untersmayr, 2003, Antacid medication inhibits digestion of dietary proteins and causes food allergy: a fish allergy model in BALB/c mice, J Allergy Clin Immunol, 112, 616, 10.1016/S0091-6749(03)01719-6 Herbert, 2013, Maternal intolerance of uncertainty, anxiety, and adherence with food challenge referrals, J Health Psychol, 18, 1209, 10.1177/1359105312459895 Strinnholm, 2010, Experiences of double-blind, placebo-controlled food challenges (DBPCFC): a qualitative analysis of mothers’ experiences, J Child Health Care, 14, 179, 10.1177/1367493509359227 Weiss, 2016, Coping and posttraumatic stress symptoms in children with food allergies, Ann Allergy Asthma Immunol, 117, 561, 10.1016/j.anai.2016.08.022 Franxman, 2015, Oral food challenge and food allergy quality of life in caregivers of children with food allergy, J Allergy Clin Immunol Pract, 3, 50, 10.1016/j.jaip.2014.06.016 Kansen, 2018, The impact of oral food challenges for food allergy on quality of life: a systematic review, Pediatr Allergy Immunol, 29, 527, 10.1111/pai.12905 Knibb, 2012, The psychological impact of diagnostic food challenges to confirm the resolution of peanut or tree nut allergy, Clin Exp Allergy, 42, 451, 10.1111/j.1365-2222.2011.03905.x Soller, 2014, The impact of oral food challenge tests on food allergy health-related quality of life, Allergy, 69, 1255, 10.1111/all.12442 van der Velde, 2012, Food allergy-related quality of life after double-blind, placebo-controlled food challenges in adults, adolescents, and children, J Allergy Clin Immunol, 130, 1136, 10.1016/j.jaci.2012.05.037 Zijlstra, 2010, Parental anxiety before and after food challenges in children with suspected peanut and hazelnut allergy, Pediatr Allergy Immunol, 21, e439, 10.1111/j.1399-3038.2009.00929.x Bird, 2017, Conducting an oral food challenge to peanut in an infant, J Allergy Clin Immunol Pract, 5, 301, 10.1016/j.jaip.2016.07.019 Jarvinen, 2009, Epinephrine treatment is infrequent and biphasic reactions are rare in food-induced reactions during oral food challenges in children, J Allergy Clin Immunol, 124, 1267, 10.1016/j.jaci.2009.10.006 Noone, 2015, Epinephrine use in positive oral food challenges performed as a screening test for food allergy therapy trials, J Allergy Clin Immunol Pract, 3, 424, 10.1016/j.jaip.2014.10.008 Muraro, 2014, Anaphylaxis: guidelines from the European Academy of Allergy and Clinical Immunology, Allergy, 69, 1026, 10.1111/all.12437 Wensing, 2002, The range of minimum provoking doses in hazelnut-allergic patients as determined by double-blind, placebo-controlled food challenges, Clin Exp Allergy, 32, 1757, 10.1046/j.1365-2222.2002.01555.x May, 1976, Objective clinical and laboratory studies of immediate hypersensitivity reactions to foods in asthmatic children, J Allergy Clin Immunol, 58, 500, 10.1016/0091-6749(76)90194-9 Sicherer, 2000, Dose-response in double-blind, placebo-controlled oral food challenges in children with atopic dermatitis, J Allergy Clin Immunol, 105, 582, 10.1067/mai.2000.104941 American Academy of Pediatrics. Available from: HealthyChildren.org. Accessed February 5, 2018. Bernhisel-Broadbent, 1992, Fish hypersensitivity, II: clinical relevance of altered fish allergenicity caused by various preparation methods, J Allergy Clin Immunol, 90, 622, 10.1016/0091-6749(92)90135-O Sicherer, 2014, Food allergy: epidemiology, pathogenesis, diagnosis, and treatment, J Allergy Clin Immunol, 133, 291, 10.1016/j.jaci.2013.11.020 Perry, 2004, Risk of oral food challenges, J Allergy Clin Immunol, 114, 1164, 10.1016/j.jaci.2004.07.063 Vlieg-Boerstra, 2008, Should children with a history of anaphylaxis to foods undergo challenge testing?, Clin Exp Allergy, 38, 1935, 10.1111/j.1365-2222.2008.03088.x Ballmer-Weber, 2018, Food challenges, J Allergy Clin Immunol, 141, 69, 10.1016/j.jaci.2017.06.038 Allen, 2009, Dietary advice, dietary adherence and the acquisition of tolerance in egg-allergic children: a 5-yr follow-up, Pediatr Allergy Immunol, 20, 213, 10.1111/j.1399-3038.2008.00784.x Kim, 2011, Dietary baked milk accelerates the resolution of cow’s milk allergy in children, J Allergy Clin Immunol, 128, 125, 10.1016/j.jaci.2011.04.036 Konstantinou, 2008, Consumption of heat-treated egg by children allergic or sensitized to egg can affect the natural course of egg allergy: hypothesis-generating observations, J Allergy Clin Immunol, 122, 414, 10.1016/j.jaci.2008.05.032 Leonard, 2012, Dietary baked egg accelerates resolution of egg allergy in children, J Allergy Clin Immunol, 130, 473, 10.1016/j.jaci.2012.06.006 Lambert, 2017, Evidence that eating baked egg or milk influences egg or milk allergy resolution: a systematic review, Clin Exp Allergy, 47, 829, 10.1111/cea.12940 Nowak-Wegrzyn, 2008, Tolerance to extensively heated milk in children with cow’s milk allergy, J Allergy Clin Immunol, 122, 342, 10.1016/j.jaci.2008.05.043 Lemon-Mule, 2008, Immunologic changes in children with egg allergy ingesting extensively heated egg, J Allergy Clin Immunol, 122, 977, 10.1016/j.jaci.2008.09.007 Calvani, 2015, Is it possible to make a diagnosis of raw, heated, and baked egg allergy in children using cutoffs? A systematic review, Pediatr Allergy Immunol, 26, 509, 10.1111/pai.12432 McGee, 2002, Simplifying likelihood ratios, J Gen Intern Med, 17, 646, 10.1046/j.1525-1497.2002.10750.x Leonard, 2015, Baked milk- and egg-containing diet in the management of milk and egg allergy, J Allergy Clin Immunol Pract, 3, 13, 10.1016/j.jaip.2014.10.001 Nowak-Wegrzyn, 2009, Rare, medium, or well done? The effect of heating and food matrix on food protein allergenicity, Curr Opin Allergy Clin Immunol, 9, 234, 10.1097/ACI.0b013e32832b88e7 Lee, 2015, Adherence to extensively heated egg and cow’s milk after successful oral food challenge, J Allergy Clin Immunol Pract, 3, 125, 10.1016/j.jaip.2014.08.013 Nowak-Wegrzyn, 2017, International consensus guidelines for the diagnosis and management of food protein-induced enterocolitis syndrome: executive summary—Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology, J Allergy Clin Immunol, 139, 1111, 10.1016/j.jaci.2016.12.966 Leung, 2013, Tolerance of baked milk in patients with cow’s milk-mediated eosinophilic esophagitis, J Allergy Clin Immunol, 132, 1215, 10.1016/j.jaci.2013.08.017 Togias, 2017, Addendum guidelines for the prevention of peanut allergy in the United States: report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel, J Allergy Clin Immunol, 139, 29, 10.1016/j.jaci.2016.10.010 Bergmann, 2013, Evaluation of food allergy in patients with atopic dermatitis, J Allergy Clin Immunol Pract, 1, 22, 10.1016/j.jaip.2012.11.005 Simons, 2015, Anaphylaxis: unique aspects of clinical diagnosis and management in infants (birth to age 2 years), J Allergy Clin Immunol, 135, 1125, 10.1016/j.jaci.2014.09.014 Rudders, 2011, Age-related differences in the clinical presentation of food-induced anaphylaxis, J Pediatr, 158, 326, 10.1016/j.jpeds.2010.10.017 Gimenez, 2011, Vocal cord dysfunction: an update, Ann Allergy Asthma Immunol, 106, 267, 10.1016/j.anai.2010.09.004 Bahna, 2014, Munchausen stridor—a strong false alarm of anaphylaxis, Allergy Asthma Immunol Res, 6, 577, 10.4168/aair.2014.6.6.577 Sampson, 2014, Food allergy: a practice parameter update-2014, J Allergy Clin Immunol, 134, 1016, 10.1016/j.jaci.2014.05.013 Aleman, 2004, Allergy to kiwi: a double-blind, placebo-controlled food challenge study in patients from a birch-free area, J Allergy Clin Immunol, 113, 543, 10.1016/j.jaci.2003.11.043 Adachi, 2009, Soybean beta-conglycinin as the main allergen in a patient with food-dependent exercise-induced anaphylaxis by tofu: food processing alters pepsin resistance, Clin Exp Allergy, 39, 167, 10.1111/j.1365-2222.2008.03148.x Aihara, 2001, Frequency of food-dependent, exercise-induced anaphylaxis in Japanese junior-high-school students, J Allergy Clin Immunol, 108, 1035, 10.1067/mai.2001.119914 Feldweg, 2017, Food-dependent, exercise-induced anaphylaxis: diagnosis and management in the outpatient setting, J Allergy Clin Immunol Pract, 5, 283, 10.1016/j.jaip.2016.11.022 Aihara, 2002, Food-dependent exercise-induced anaphylaxis: influence of concurrent aspirin administration on skin testing and provocation, Br J Dermatol, 146, 466, 10.1046/j.1365-2133.2002.04601.x Brockow, 2015, Using a gluten oral food challenge protocol to improve diagnosis of wheat-dependent exercise-induced anaphylaxis, J Allergy Clin Immunol, 135, 977, 10.1016/j.jaci.2014.08.024 Hanakawa, 1998, Food-dependent exercise-induced anaphylaxis: a case related to the amount of food allergen ingested, Br J Dermatol, 138, 898, 10.1046/j.1365-2133.1998.02254.x Romano, 2001, Food-dependent exercise-induced anaphylaxis: clinical and laboratory findings in 54 subjects, Int Arch Allergy Immunol, 125, 264, 10.1159/000053825 Romano, 1995, Diagnostic work-up for food-dependent, exercise-induced anaphylaxis, Allergy, 50, 817, 10.1111/j.1398-9995.1995.tb05055.x Kohno, 2013, Serum gliadin monitoring extracts patients with false-negative results in challenge tests for the diagnosis of wheat-dependent exercise-induced anaphylaxis, Allergol Int, 62, 229, 10.2332/allergolint.12-OA-0495 Scherf, 2016, Wheat-dependent exercise-induced anaphylaxis, Clin Exp Allergy, 46, 10, 10.1111/cea.12640 Gleich, 2016, Shrimp allergy: gastrointestinal symptoms commonly occur in the absence of IgE sensitization, J Allergy Clin Immunol Pract, 4, 316, 10.1016/j.jaip.2015.09.020 Tan, 2014, Non-IgE-mediated gastrointestinal food hypersensitivity syndrome in adults, J Allergy Clin Immunol Pract, 2, 355, 10.1016/j.jaip.2014.02.002 Fernandes, 2012, Food protein-induced enterocolitis syndrome can occur in adults, J Allergy Clin Immunol, 130, 1199, 10.1016/j.jaci.2012.06.017 Boyce, 2011, Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-sponsored Expert Panel Report, Nutrition, 27, 253, 10.1016/j.nut.2010.12.001 Caubet, 2014, Clinical features and resolution of food protein-induced enterocolitis syndrome: 10-year experience, J Allergy Clin Immunol, 134, 382, 10.1016/j.jaci.2014.04.008 Ruffner, 2013, Food protein-induced enterocolitis syndrome: insights from review of a large referral population, J Allergy Clin Immunol Pract, 1, 343, 10.1016/j.jaip.2013.05.011 Ruiz-Garcia, 2014, Diagnosis and natural history of food protein-induced enterocolitis syndrome in children from a tertiary hospital in central Spain, J Investig Allergol Clin Immunol, 24, 354 Sopo, 2012, A multicentre retrospective study of 66 Italian children with food protein-induced enterocolitis syndrome: different management for different phenotypes, Clin Exp Allergy, 42, 1257, 10.1111/j.1365-2222.2012.04027.x Zapatero Remon, 2005, Food-protein-induced enterocolitis syndrome caused by fish, Allergol Immunopathol (Madr), 33, 312, 10.1016/S0301-0546(05)73249-3 Ludman, 2014, Clinical presentation and referral characteristics of food protein-induced enterocolitis syndrome in the United Kingdom, Ann Allergy Asthma Immunol, 113, 290, 10.1016/j.anai.2014.06.020 Hsu, 2013, Egg: a frequent trigger of food protein-induced enterocolitis syndrome, J Allergy Clin Immunol, 131, 241, 10.1016/j.jaci.2012.08.045 Jarvinen, 2012, Diagnostic oral food challenges: procedures and biomarkers, J Immunol Methods, 383, 30, 10.1016/j.jim.2012.02.019 Nowak-Wegrzyn, 2009, Food protein-induced enterocolitis syndrome, Curr Opin Allergy Clin Immunol, 9, 371, 10.1097/ACI.0b013e32832d6315 Powell, 1978, Milk- and soy-induced enterocolitis of infancy: clinical features and standardization of challenge, J Pediatr, 93, 553, 10.1016/S0022-3476(78)80887-7 Sicherer, 2005, Food protein-induced enterocolitis syndrome: case presentations and management lessons, J Allergy Clin Immunol, 115, 149, 10.1016/j.jaci.2004.09.033 Feuille, 2014, Definition, etiology, and diagnosis of food protein-induced enterocolitis syndrome, Curr Opin Allergy Clin Immunol, 14, 222, 10.1097/ACI.0000000000000055 Nowak-Wegrzyn, 2017 Hourihane, 1997, An evaluation of the sensitivity of subjects with peanut allergy to very low doses of peanut protein: a randomized, double-blind, placebo-controlled food challenge study, J Allergy Clin Immunol, 100, 596, 10.1016/S0091-6749(97)70161-1 Peeters, 2007, Lupine allergy: not simply cross-reactivity with peanut or soy, J Allergy Clin Immunol, 120, 647, 10.1016/j.jaci.2007.05.032 Vlieg-Boerstra, 2004, Development and validation of challenge materials for double-blind, placebo-controlled food challenges in children, J Allergy Clin Immunol, 113, 341, 10.1016/j.jaci.2003.10.039 van Maaren, 2016, Dutch guideline on food allergy, Neth J Med, 74, 376 Vlieg-Boerstra, 2011, Validation of novel recipes for double-blind, placebo-controlled food challenges in children and adults, Allergy, 66, 948, 10.1111/j.1398-9995.2010.02539.x Cochrane, 2012, Development of a standardized low-dose double-blind placebo-controlled challenge vehicle for the EuroPrevall project, Allergy, 67, 107, 10.1111/j.1398-9995.2011.02715.x Busse, 2002, Recurrent peanut allergy, N Engl J Med, 347, 1535, 10.1056/NEJM200211073471921 Fleischer, 2003, The natural progression of peanut allergy: resolution and the possibility of recurrence, J Allergy Clin Immunol, 112, 183, 10.1067/mai.2003.1517 Nachshon, 2018, Food allergy to previously tolerated foods: course and patient characteristics, Ann Allergy Asthma Immunol, 121, 77, 10.1016/j.anai.2018.04.012 Chang, 2016, Natural history of food-triggered atopic dermatitis and development of immediate reactions in children, J Allergy Clin Immunol Pract, 4, 229, 10.1016/j.jaip.2015.08.006 Du Toit, 2015, Randomized trial of peanut consumption in infants at risk for peanut allergy, N Engl J Med, 372, 803, 10.1056/NEJMoa1414850 Nowak-Wegrzyn, 2009, Work Group report: oral food challenge testing, J Allergy Clin Immunol, 123, S365, 10.1016/j.jaci.2009.03.042 Sampson, 2001, Utility of food-specific IgE concentrations in predicting symptomatic food allergy, J Allergy Clin Immunol, 107, 891, 10.1067/mai.2001.114708 Perry, 2004, The relationship of allergen-specific IgE levels and oral food challenge outcome, J Allergy Clin Immunol, 114, 144, 10.1016/j.jaci.2004.04.009 Sporik, 2000, Specificity of allergen skin testing in predicting positive open food challenges to milk, egg and peanut in children, Clin Exp Allergy, 30, 1540, 10.1046/j.1365-2222.2000.00928.x Garcia-Ara, 2001, Specific IgE levels in the diagnosis of immediate hypersensitivity to cows’ milk protein in the infant, J Allergy Clin Immunol, 107, 185, 10.1067/mai.2001.111592 Knight, 2006, Skin prick test to egg white provides additional diagnostic utility to serum egg white-specific IgE antibody concentration in children, J Allergy Clin Immunol, 117, 842, 10.1016/j.jaci.2005.12.1304 Boyano-Martinez, 2002, Prediction of tolerance on the basis of quantification of egg white-specific IgE antibodies in children with egg allergy, J Allergy Clin Immunol, 110, 304, 10.1067/mai.2002.126081 Sicherer, 2000, Dose-response in double-blind, placebo-controlled oral food challenges in children with atopic dermatitis, J Allergy Clin Immunol, 105, 582, 10.1067/mai.2000.104941 Roberts, 2005, Diagnosing peanut allergy with skin prick and specific IgE testing, J Allergy Clin Immunol, 115, 1291, 10.1016/j.jaci.2005.02.038 Sicherer, 2006, An expanding evidence base provides food for thought to avoid indigestion in managing difficult dilemmas in food allergy, J Allergy Clin Immunol, 117, 1419, 10.1016/j.jaci.2006.01.051 Sampson, 2012, Standardizing double-blind, placebo-controlled oral food challenges: American Academy of Allergy, Asthma & Immunology-European Academy of Allergy and Clinical Immunology PRACTALL consensus report, J Allergy Clin Immunol, 130, 1260, 10.1016/j.jaci.2012.10.017 Mazor, 2018 Campbell, 2018 Fleming, 2011, Normal ranges of heart rate and respiratory rate in children from birth to 18 years of age: a systematic review of observational studies, Lancet, 377, 1011, 10.1016/S0140-6736(10)62226-X Bird, 2017, Conducting an oral food challenge to peanut in an infant, J Allergy Clin Immunol Pract, 5, 301, 10.1016/j.jaip.2016.07.019 Nowak-Wegrzyn, 2008, Tolerance to extensively heated milk in children with cow’s milk allergy, J Allergy Clin Immunol, 122, 342, 10.1016/j.jaci.2008.05.043 Bartnikas, 2012, Predicting food challenge outcomes for baked milk: role of specific IgE and skin prick testing, Ann Allergy Asthma Immunol, 109, 309, 10.1016/j.anai.2012.07.026 Caubet, 2013, Utility of casein-specific IgE levels in predicting reactivity to baked milk, J Allergy Clin Immunol, 131, 222, 10.1016/j.jaci.2012.06.049 Lemon-Mule, 2008, Immunologic changes in children with egg allergy ingesting extensively heated egg, J Allergy Clin Immunol, 122, 977, 10.1016/j.jaci.2008.09.007 Ando, 2008, Utility of ovomucoid-specific IgE concentrations in predicting symptomatic egg allergy, J Allergy Clin Immunol, 122, 583, 10.1016/j.jaci.2008.06.016 Lieberman, 2012, Outcomes of 100 consecutive open, baked-egg oral food challenges in the allergy office, J Allergy Clin Immunol, 129, 1682, 10.1016/j.jaci.2012.04.007 Caubet, 2012, Significance of ovomucoid- and ovalbumin-specific IgE/IgG(4) ratios in egg allergy, J Allergy Clin Immunol, 129, 739, 10.1016/j.jaci.2011.11.053 Tan, 2013, Baked egg food challenges—clinical utility of skin test to baked egg and ovomucoid in children with egg allergy, Clin Exp Allergy, 43, 1189 Bartnikas, 2013, Ovomucoid is not superior to egg white testing in predicting tolerance to baked egg, J Allergy Clin Immunol Pract, 1, 354, 10.1016/j.jaip.2013.04.002 Peters, 2013, Skin prick test responses and allergen-specific IgE levels as predictors of peanut, egg, and sesame allergy in infants, J Allergy Clin Immunol, 132, 874, 10.1016/j.jaci.2013.05.038 Turner, 2014, Skin testing with raw egg does not predict tolerance to baked egg in egg-allergic children, Pediatr Allergy Immunol, 25, 657, 10.1111/pai.12291 Saifi, 2016, Tolerance of a high-protein baked-egg product in egg-allergic children, Ann Allergy Asthma Immunol, 116, 415, 10.1016/j.anai.2015.12.012 Leonard, 2015, Baked milk- and egg-containing diet in the management of milk and egg allergy, J Allergy Clin Immunol Pract, 3, 13, 10.1016/j.jaip.2014.10.001 Nowak-Wegrzyn, 2017, International consensus guidelines for the diagnosis and management of food protein-induced enterocolitis syndrome: executive summary—Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology, J Allergy Clin Immunol, 139, 1111, 10.1016/j.jaci.2016.12.966 Vlieg-Boerstra, 2004, Development and validation of challenge materials for double-blind, placebo-controlled food challenges in children, J Allergy Clin Immunol, 113, 341, 10.1016/j.jaci.2003.10.039 van Odijk, 2005, Double-blind placebo-controlled challenges for peanut allergy, the efficiency of blinding procedures and the allergenic activity of peanut availability in the recipes, Allergy, 60, 602, 10.1111/j.1398-9995.2005.00666.x de Jong, 2010, Sensitization to lupine flour: is it clinically relevant?, Clin Exp Allergy, 40, 1571, 10.1111/j.1365-2222.2010.03496.x Vassilopoulou, 2010, Evaluation and standardisation of different matrices used for double-blind placebo-controlled food challenges to fish, J Hum Nutr Diet, 23, 544, 10.1111/j.1365-277X.2010.01046.x Vlieg-Boerstra, 2011, Validation of novel recipes for double-blind, placebo-controlled food challenges in children and adults, Allergy, 66, 948, 10.1111/j.1398-9995.2010.02539.x Venter, 2016, Validation and acceptability of double-blind, placebo-controlled food challenges in children, Pediatr Allergy Immunol, 27, 92, 10.1111/pai.12454 Gonzalez-Mancebo, 2017, Validation of recipes for double-blind placebo-controlled challenges with milk, egg white, and hazelnut, J Investig Allergol Clin Immunol, 27, 40, 10.18176/jiaci.0084 Chef Martin. Home. Available from: www.chefmartin.nl. Accessed April 25, 2018. Iwan, 2011, Impact of Maillard reaction on immunoreactivity and allergenicity of the hazelnut allergen Cor a 11, J Agric Food Chem, 59, 7163, 10.1021/jf2007375