Concomitant use of gastric acid‐reducing agents is frequent among HIV‐1‐infected patients receiving protease inhibitor‐based highly active antiretroviral therapy*

HIV Medicine - Tập 8 Số 4 - Trang 220-225 - 2007
Jan van Lunzen1, H.-D. Liess2,3, Keikawus Arastéh4, R Walli5, B Daut5, D. Schürmann6
1University Medical Center Hamburg-Eppendorf, Infectious Diseases Unit, Hamburg, Germany
2Ludwig-Maximilians University, Medizinische Poliklinik, ID Outpatient Clinic, Munich, Germany,
3Vertex Pharmaceuticals (Europe) Ltd, Abingdon, UK
4Vivantes Auguste Viktoria Klinikum, Department of Gastroenterology/Infectious Diseases, Berlin, Germany,
5GlaxoSmithKline, Munich, Germany, and
6Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany.

Tóm tắt

ObjectiveThe aim of the study was to assess the frequency of the concurrent use of gastric acid‐reducing agents among HIV‐1‐infected patients treated with highly active antiretroviral therapy (HAART) combinations.MethodsAn anonymous, semistructured, self‐administered questionnaire was consecutively distributed among HIV‐1‐infected patients at routine visits to specialized HIV clinics. The questionnaire contained 17 items asking specifically for information on current antiretroviral treatments and the use of gastric acid‐reducing agents as well as demographic data.ResultsA total of 424 patients in 12 centres participated in the study: 85% were male, 88% were of German nationality, 82% were >35 years of age and 201 (47.4%) were receiving a protease inhibitor (PI)‐containing HAART regimen. Of these, 74 (37%) had received an acid‐reducing drug within the previous 6 months and 43 (58%) were currently still on it. Two‐thirds of patients (64.9%) were treated with proton‐pump inhibitors (pantoprazole, omeprazole or esomeprazole) and 56% of patients on PI‐containing regimens had been taking these drugs for longer than 2 months and up to a maximum of 3 years. The majority of patients (77%) had received the prescription for the acid‐reducing drugs from their HIV specialist and the remaining patients had received over the counter (OTC) medication or prescriptions from other medical personnel.ConclusionsA substantial subset of patients treated with HAART combinations, including those on PI‐containing regimens, were using concomitant acid‐reducing drugs, most often proton‐pump inhibitors. As negative drug–drug interactions between some of the (boosted) PIs and gastric acid‐reducing agents have recently been reported, HIV physicians should take this into account when prescribing PI‐containing HAART combinations in order to avoid an additional risk of treatment failure.

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HIV Medicine

Tập 8 Số 4

220-225

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