Concealed use of herbal and dietary supplements among Thai patients with type 2 diabetes mellitus

Journal of Diabetes & Metabolic Disorders - Tập 16 - Trang 1-7 - 2017
Prapaipan Putthapiban1,2, Weera Sukhumthammarat1,3, Chutintorn Sriphrapradang1
1Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
2Faculty of Science, Mahidol University, Bangkok, Thailand
3Faculty of Dentistry, Mahidol University Bangkok, Thailand

Tóm tắt

Diabetes mellitus (DM) has been one of the most common chronic diseases that create great impacts on both morbidities and mortalities. Many patients who suffering from this disease seek for complementary and alternative medicine. The aim of this study was to determine the prevalence and related factors of herbal and dietary supplement (HDS) use in patients with DM type 2 at a single university hospital in Thailand. A cross-sectional study was performed in 200 type 2 DM patients via face-to-face structured interviews using developed questionnaires comprised of demographic data, diabetes-specific information, details on HDS use, and medical adherence. From the endocrinology clinic, 61% of total patients reported HDS exposure and 28% were currently consuming. More than two-thirds of HDS users did not notify their physicians, mainly because of a lack of doctor concern; 73% of cases had no awareness of potential drug-herb interaction. The use of drumstick tree, turmeric and bitter gourd and holy mushroom were most frequently reported. The main reasons for HDS use were friend and relative suggestions and social media. Comparisons of demographic characteristics, medical adherence, and hemoglobin A1c among these non-HDS users, as well as current and former users, were not statistically significantly different. This study revealed a great number of DM patients interested in HDS use. The use of HDS for glycemic control is an emerging public health concern given the potential adverse effects, drug interactions and benefits associated with its use. Health care professionals should aware of HDS use and hence incorporate this aspect into the clinical practice.

Tài liệu tham khảo

National Center for Complementary and Integrative health, National Institutes of Health. Complementary, Alternative, or Integrative Health: What's In a Name? 2016. https://nccih.nih.gov/health/integrative-health. Accessed 24 May 2017. Clarke TC, Black LI, Stussman BJ, Barnes PM, Nahin RL. Trends in the use of complementary health approaches among adults: United States. Natl Health Stat Report. 2002-2012;2015:1–16. Wu CH, Wang CC, Tsai MT, Huang WT, Kennedy J. Trend and pattern of herb and supplement use in the United States: results from the 2002, 2007, and 2012 national health interview surveys. Evid Based Complement Alternat Med. 2014;2014:872320. Bell RA, Suerken CK, Grzywacz JG, Lang W, Quandt SA, Arcury TA. Complementary and alternative medicine use among adults with diabetes in the United States. Altern Ther Health Med. 2006;12:16–22. Yeh GY, Eisenberg DM, Davis RB, Phillips RS. Use of complementary and alternative medicine among persons with diabetes mellitus: results of a national survey. Am J Public Health. 2002;92:1648–52. Garrow D, Egede LE. National patterns and correlates of complementary and alternative medicine use in adults with diabetes. J Altern Complement Med. 2006;12:895–902. Garrow D, Egede LE. Association between complementary and alternative medicine use, preventive care practices, and use of conventional medical services among adults with diabetes. Diabetes Care. 2006;29:15–9. Medagama AB, Bandara R, Abeysekera RA, Imbulpitiya B, Pushpakumari T. Use of complementary and alternative medicines (CAMs) among type 2 diabetes patients in Sri Lanka: a cross sectional survey. BMC Complement Altern Med. 2014;14 Saydah SH, Eberhardt MS. Use of complementary and alternative medicine among adults with chronic diseases: United States 2002. J Altern Complement Med. 2006;12:805–12. Eisenberg DM, Davis RB, Ettner SL, Appel S, Wilkey S, Van Rompay M, et al. Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. JAMA. 1998;280:1569–75. Astin JA. Why patients use alternative medicine: results of a national study. JAMA. 1998;279:1548–53. Egede LE, Ye X, Zheng D, Silverstein MD. The prevalence and pattern of complementary and alternative medicine use in individuals with diabetes. Diabetes Care. 2002;25:324–9. Ceylan S, Azal O, Taslipinar A, Turker T, Acikel CH, Gulec M. Complementary and alternative medicine use among Turkish diabetes patients. Complement Ther Med. 2009;17:78–83. McCaffrey AM, Pugh GF, O'Connor BB. Understanding patient preference for integrative medical care: results from patient focus groups. J Gen Intern Med. 2007;22:1500–5. Nahin RL, Byrd-Clark D, Stussman BJ, Kalyanaraman N. Disease severity is associated with the use of complementary medicine to treat or manage type-2 diabetes: data from the 2002 and 2007 National Health Interview Survey. BMC Complement Altern Med. 2012;12:193. Moolasarn S, Sripa S, Kuessirikiet V, Sutawee K, Huasary J, Chaisila C, et al. Usage of and cost of complementary/alternative medicine in diabetic patients. J Med Assoc Thail. 2005;88:1630–7. Tangkiatkumjai M, Boardman H, Praditpornsilpa K, Walker DM. Prevalence of herbal and dietary supplement usage in Thai outpatients with chronic kidney disease: a cross-sectional survey. BMC Complement Altern Med. 2013;13:153. Tangkiatkumjai M, Boardman H, Praditpornsilpa K, Walker DM. Reasons why Thai patients with chronic kidney disease use or do not use herbal and dietary supplements. BMC Complement Altern Med. 2014;14:473. Medagama AB, Bandara R. The use of complementary and alternative medicines (CAMs) in the treatment of diabetes mellitus: is continued use safe and effective? Nutr J. 2014;13:102. Al-Malki AL, El Rabey HA. The antidiabetic effect of low doses of Moringa oleifera Lam seeds on streptozotocin induced diabetes and diabetic nephropathy in male rats. Biomed Res Int. 2015;2015:381040. Rungseesantivanon S, Thenchaisri N, Ruangvejvorachai P, Patumraj S. Curcumin supplementation could improve diabetes-induced endothelial dysfunction associated with decreased vascular superoxide production and PKC inhibition. BMC Complement Altern Med. 2010;10:57. Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R, Phisalaphong C, Jirawatnotai S. Curcumin extract for prevention of type 2 diabetes. Diabetes Care. 2012;35:2121–7. Prabhakar PK, Kumar A, Doble M. Combination therapy: a new strategy to manage diabetes and its complications. Phytomedicine. 2014;21:123–30. Sakthong P, Chabunthom R, Charoenvisuthiwongs R. Psychometric properties of the Thai version of the 8-item Morisky medication adherence scale in patients with type 2 diabetes. Ann Pharmacother. 2009;43:950–7. American Diabetes Association. 2. Classification and Diagnosis of Diabetes. Diabetes Care. 2017;40(Suppl 1):S11-S24. Kumar D, Bajaj S, Mehrotra R. Knowledge, attitude and practice of complementary and alternative medicines for diabetes. Public Health. 2006;120:705–11. Lim MK, Sadarangani P, Chan HL, Heng JY. Complementary and alternative medicine use in multiracial Singapore. Complement Ther Med. 2005;13:16–24. Kristoffersen AE, Stub T, Salamonsen A, Musial F, Hamberg K. Gender differences in prevalence and associations for use of CAM in a large population study. BMC Complement Altern Med. 2014;14:463. Weidenhammer W, Lacruz ME, Emeny RT, Linde K, Peters A, Thorand B, et al. Prevalence of use and level of awareness of CAM in older people - results from the KORA-age study. Forsch Komplementmed. 2014;21:294–301. Abdull Razis AF, Ibrahim MD, Kntayya SB. Health benefits of Moringa Oleifera. Asian Pac J Cancer Prev. 2014;15:8571–6. Kar A, Choudhary BK, Bandyopadhyay NG. Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats. J Ethnopharmacol. 2003;84:105–8. Stohs SJ, Hartman MJ. Review of the safety and efficacy of Moringa Oleifera. Phytother Res. 2015;29:796–804. Mbikay M. Therapeutic potential of Moringa Oleifera leaves in chronic hyperglycemia and dyslipidemia: a review. Front Pharmacol. 2012;3:24. Maradana MR, Thomas R, O'Sullivan BJ. Targeted delivery of curcumin for treating type 2 diabetes. Mol Nutr Food Res. 2013;57:1550–6. Lao CD, Ruffin MT 4th, Normolle D, Heath DD, Murray SI, Bailey JM, et al. Dose escalation of a curcuminoid formulation. BMC Complement Altern Med. 2006;6:10. Srinivasan M. Effect of curcumin on blood sugar as seen in a diabetic subject. Indian J Med Sci. 1972;26:269–70. Fischer FH, Lewith G, Witt CM, Linde K, von Ammon K, Cardini F, et al. High prevalence but limited evidence in complementary and alternative medicine: guidelines for future research. BMC Complement Altern Med. 2014;14:46. Ching CK, Lam YH, Chan AY, Mak TW. Adulteration of herbal antidiabetic products with undeclared pharmaceuticals: a case series in Hong Kong. Br J Clin Pharmacol. 2012;73:795–800. Ernst E. Adulteration of Chinese herbal medicines with synthetic drugs: a systematic review. J Intern Med. 2002;252:107–13. Posadzki P, Watson L, Ernst E. Contamination and adulteration of herbal medicinal products (HMPs): an overview of systematic reviews. Eur J Clin Pharmacol. 2013;69:295–307. Naja F, Mousa D, Alameddine M, Shoaib H, Itani L, Mourad Y. Prevalence and correlates of complementary and alternative medicine use among diabetic patients in Beirut. Lebanon: a cross-sectional study BMC Complement Altern Med. 2014;14:185. Chretien KC, Kind T. Social media and clinical care: ethical, professional, and social implications. Circulation. 2013;127:1413–21. Greene JA, Choudhry NK, Kilabuk E, Shrank WH. Online social networking by patients with diabetes: a qualitative evaluation of communication with Facebook. J Gen Intern Med. 2011;26:287–92. Zablocka-Slowinska K, Dzielska E, Gryszkin I, Grajeta H. Dietary supplementation during diabetes therapy and the potential risk of interactions. Adv Clin Exp Med. 2014;23:939–46. Frenkel MA, Borkan JM. An approach for integrating complementary-alternative medicine into primary care. Fam Pract. 2003;20:324–32.