Conazoles

Springer Science and Business Media LLC - Tập 15 Số 6 - Trang 4129-4188
Jan Heeres1, Lieven Meerpoel2, Paul Lewi3
1Leemskuilen 18, B-2350 Vosselaar, Belgium
2Johnson & Johnson Pharmaceutical Research & Development, a division of Janssen Pharmaceutica N.V.,Turnhoutseweg 30, B-2340 Beerse, Belgium
3Pater Van Mierlostraat 18, B-2300 Turnhout, Belgium

Tóm tắt

This review provides a historical overview of the analog based drug discovery of miconazole and its congeners, and is focused on marketed azole antifungals bearing the generic suffix “conazole”. The antifungal activity of miconazole, one of the first broad-spectrum antimycotic agents has been mainly restricted to topical applications. The attractive in vitro antifungal spectrum was a starting point to design more potent and especially orally active antifungal agents such as ketoconazole, itraconazole, posaconazole, fluconazole and voriconazole. The chemistry, in vitro and in vivo antifungal activity, pharmacology, and clinical applications of these marketed conazoles has been described.

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