Computational meta'omics for microbial community studies

Molecular Systems Biology - Tập 9 Số 1 - 2013
Nicola Segata1, Daniela Boernigen1,2, Timothy L. Tickle1,2, Xochitl C. Morgan1,2, Wendy S. Garrett3,4,5,2, Curtis Huttenhower1,2
1Biostatistics Department, Harvard School of Public Health Boston MA USA
2The Broad Institute of MIT and Harvard, Cambridge, MA, USA
3Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
4Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
5Department of Medicine, Harvard Medical School, Boston, MA USA

Tóm tắt

Complex microbial communities are an integral part of the Earth's ecosystem and of our bodies in health and disease. In the last two decades, culture‐independent approaches have provided new insights into their structure and function, with the exponentially decreasing cost of high‐throughput sequencing resulting in broadly available tools for microbial surveys. However, the field remains far from reaching a technological plateau, as both computational techniques and nucleotide sequencing platforms for microbial genomic and transcriptional content continue to improve. Current microbiome analyses are thus starting to adopt multiple and complementary meta'omic approaches, leading to unprecedented opportunities to comprehensively and accurately characterize microbial communities and their interactions with their environments and hosts. This diversity of available assays, analysis methods, and public data is in turn beginning to enable microbiome‐based predictive and modeling tools. We thus review here the technological and computational meta'omics approaches that are already available, those that are under active development, their success in biological discovery, and several outstanding challenges.

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Molecular Systems Biology

Tập 9 Số 1

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