Complications of Laser in situ Keratomileusis: Etiology, Prevention, and Treatment

Journal of Refractive Surgery - Tập 17 Số 3 - Trang 350-379 - 2001
Renato Ambrósio1, Steven E. Wilson2
1Department of Ophthalmology, University of Sao Paulo, Brazil
2University of Washington

Tóm tắt

ABSTRACT PURPOSE: To review the etiology, prevention, and management of laser in situ keratomileusis (LASIK) complications. METHODS: Review of literature and the experience of the authors. RESULTS: Careful preoperative screening is critical to prevention of many potential complications of LASIK. Flap complications that occur during surgery are typically managed by replacement of the flap and repeating the surgery or applying special methods such as transepithelial photorefractive keratectomy weeks to months following the initial procedure. A common source of serious complications is the use of a microkeratome that functions after improper assembly. Timely treatment of postoperative complications such as diffuse lamellar keratitis, flap striae, and infection is critical to an optimal outcome. CONCLUSION: Most complications of LASIK can be treated effectively and have minimal effect on the final outcome after surgery, if appropriate methods are used for management. [J Refract Surg 2001;17:350-379]

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Tài liệu tham khảo

1. Wilson SE. LASIK: Management of common complications. Cornea 1998;17:459-467.

2. Knorz MC Hugger P Jendritzka B Liermann A. Twilight visual acuity after correction of myopia with LASIK. Ophthalmologe 1999;96:711-716.

3. Davidorf JM Zaldivar R Oscherow S. Results and complications of laser in situ keratomileusis by experienced surgeons. J Refract Surg 1998;14:114-122.

4. Esquenazi S Mendoza A. Two-year follow-up of laser in situ keratomileusis for hyperopia. J Refract Surg 1999;15: 648-652.

5. Wilson SE Lin DTC Klyce SD Reidy JJ Insler MS. Contact lens-induced changes in corneal topography. Ophthalmology 1990;97:734-744.

6. Wilson SE Klyce SD. Screening for corneal topographic abnormalities before refractive surgery. Ophthalmology 1994;101:147-152.

7. Buzard KA Tuengler A Febbraro JL. Treatment of mild to moderate keratoconus with laser in situ keratomileusis. J Cataract Refract Surg 1999;25:1600-1609.

8. Kremer I Shochot Y Kaplan A Blumenthal M. Three year results of photoastigmatic refractive keratectomy for mild and atypical keratoconus. J Cataract Refract Surg 1998;24:1581-1588.

9. Schmitt-Bernard CF Lesage C Arnaud B. Keratectasia induced by laser in situ keratomileusis in keratoconus. J Refract Surg 2000;16:368-370.

10. McLeod SD Kisla TA Caro NC McMahon TT. Iatrogenic keratoconus: corneal ectasia following laser in situ keratomileusis for myopia. Arch Ophthalmol 2000;118:282-284.

11. Kim W-J Rabinowitz YS Meisler DM Wilson SE. Keratocyte apoptosis associated with keratoconus. Exp Eye Res 1999;69:475-481.

12. Helena MC Baerveldt F Kim W-J Wilson SE. Keratocyte apoptosis after corneal surgery. Invest Ophthalmol Vis Sci 1998;39:276-283.

13. Smolek MK Klyce SD. Current keratoconus detection methods compared with a neural network approach. Invest Ophthalmol Vis Sci 1997;38:2290-2299.

14. Rabinowitz YS Rasheed K KISA% index: a quantitative videokeratography algorithm embodying minimal topographic criteria for diagnosing keratoconus. J Cataract Refract Surg 1999;25:1327-1333

15. Wilson SE. LASDC-induced (presumed) neurotrophic epitheliopathy (LNE). Ophthalmology in press

16. Wilson SE Ambr?sio R Jr. Laser in situ keratomileusis (LASIK)-induced neurotrophic epitheliopathy. Am J Ophthalmol in press.

17. Tanzer DJ Isfahani A Schallhorn SC La Bree LD1 McDonnell PJ. Photorefractive keratectomy in African Americans including those with known dermatologie keloid formation. Am J Ophthalmol 1998;126:625-629.

18. Bushley DM Parmley VC Paglen P. Visual field defect associated with laser in situ keratomileusis. Am J Ophthalmol 2000;129:668-671.

19. Lindstrom RL Hardten DR Chu YR. Laser in situ keratomileusis (LASIK) for the treatment of low moderate and high myopia. Trans Am Ophthalmol Soc 1997;95:285-296.

20. Wilson SE. LASHi: Management of common complications. Cornea 1998;17:459-467.

21. Farah SG Azar DT Gurdal C Wong J. Laser in situ keratomileusis: literature review of a developing technique. J Cataract Refract Surg 1998;24:989-1006.

22. Stulting RD Carr JD Thompson KP Waring GO 3rd W?ey WM Walker JG. Complications of laser in situ keratomileusis for the correction of myopia. Ophthalmology 1999;106:13-20.

23. Pallikaris IG S?ganos DS. Laser in situ keratomileusis to treat myopia. J Cataract Refract Surg 1997;23:39-49.

24. Lin RT Maloney RK Flap complications associated with lamellar refractive surgery. Am J Ophthalmol 1999; 127: 129-136.

25. Gimbel HV Basti S Kaye GB Ferensowicz M. Experience during the learning curve of laser in situ keratomileusis. J Cataract Refract Surg 1996;22:542-550.

26. Swinger CA Barker BA. Prospective evaluation of myopic keratomileusis. Ophthalmology 1984;91:785-792.

27. Bas AM Nano HD Jr. In situ myopic keratomileusis results in 30 eyes at 15 months. Refract Corneal Surg 1991;7: 223-231.

28. Brint SF Ostrick DM Fisher C Slade SG Maloney RK Epstein R Stulting RD Thompson KP. Six-month results of the multicenter phase I study of excimer laser myopic keratomileusis. J Cataract Refract Surg 1994;20:610-615.

29. Kremer I Blumenthal M. Myopic keratomileusis in situ combined with VISX 20/20 photorefractive keratectomy. J Cataract Refract Surg 1995;21:508-511.

30. Salah T Waring GO 3rd el-Maghraby A Moadel K Grimm SB. Excimer laser in-situ keratomileusis (LASDX) under a corneal flap for myopia of 2 to 20 D. Trans Am Ophthalmol Soc 1995;93:163-190.

31. Tham VM Maloney RK Microkeratome complications of laser in situ keratomileusis. Ophthalmology 2000; 107: 920-924.

32. Walker MB Wilson SE. Lower intraoperative flap complication rate with the Hansatome microkeratome compared to the Automated Corneal Shaper. J Refract Surg 2000; 16: 79-82.

33. Kapadia MS Wilson SE. Transepithelial photorefractive keratectomy for treatment of thin flaps or caps following complicated laser in situ keratomileusis. Am J Ophthalmol 1998;126:827-829.

34. Arevalo JF Ramirez E1 Suarez E Morales-Stopello J Cortez R Ramirez G Antzoulatos G Tugues J Rodriguez J Fuenmayor-Rivera D. Incidence of vitreoretinal pathologic conditions within 24 months after laser in situ keratomileusis. Ophthalmology 2000;107:258-262.

35. Davidorf JM Zaldivar R Oscherow S. Results and complications of laser in situ keratomileusis by experienced surgeons. J Refract Surg 1998;14:114-122.

36. MacRae S Macaluso DC Rich LF. Sterile interface keratitis associated with micropannus hemorrhage after laser in situ keratomileusis. J Cataract Refract Surg 1999;25:1679-1681.

37. Tsai YY Lin JM. Ablation centration after active eye-tracker-assisted photorefractive keratectomy and laser in situ keratomileusis. J Cataract Refract Surg 2000;26:28-34.

38. Pannu JS. Incidence and treatment of wrinkled corneal flap following LASIK [letter]. J Cataract Refract Surg 1997;23:695-696.

39. Munoz G AUo JL Perez-Santonja JJ. Successful treatment of severe wrinkled corneal flap after laser in situ keratomileusis with deionized water. Am J Ophthalmol 2000;29:91-92.

40. Lemley HL Chodosh J Wolf TC Bogie CP Hawkins TC. Partial dislocation of laser in situ keratomileusis flap by air bag injury. J Refract Surg 2000;16:373-374.

41. Helena MC Meisler DM Wilson SE. Epithelial growth within the lamellar interface following laser in situ keratomileusis (LASDK). Cornea 1997;16:300-305.

42. Walker MB Wilson SE. Incidence and prevention of epithelial growth within the interface after laser in situ keratomileusis. Cornea 2000;19:170-173.

43. Wang MY Maloney RK Epithelial ingrowth after laser in situ keratomileusis. Am J Ophthalmol 2000;129:746-751.

44. Castillo A Diaz-Valle D Gutierrez AR Toledano N Romero F. Peripheral melt of flap after laser in situ keratomileusis. J Refract Surg 1998;14:61-63.

45. Holladay JT Dudeja DR Chang J Functional vision and corneal changes after laser in situ keratomileusis determined by contrast sensitivity glare testing and corneal topography. J Cataract Refract Surg 1999;25:663-669.

46. Wilson SE He Y-G Weng J Li Q Vital M Chwang EL. Epithelial injury induces keratocyte apoptosis: Hypothesized role for the interleukin-1 system in the modulation of corneal tissue organization. Exp Eye Res 1996;62:325-338.

47. Perez-Santonja JJ Linna TU Tervo KM Sakla HF Alio J Sanz JL Tervo TM. Corneal wound healing after laser in situ keratomileusis in rabbits. J Refract Surg 1998; 14: 602-609.

48. Park CK Kim JH. Comparison of wound healing after photorefractive keratectomy and laser in situ keratomileusis in rabbits. J Cataract Refract Surg 1999;25:842-850.

49. Kato T Nakayasu K Hosoda Y Watanabe Y Kanai A. Corneal wound healing following laser in situ keratomileusis (LASIK): a histopathological study in rabbits. Br J Ophthalmol 1999;83:1302-1305.

50. Wachtlin J Langenbeck K Schrunder S Zhang EP Hoffmann F. Immunohistology of corneal wound healing after photorefractive keratectomy and laser in situ keratomileusis. J Refract Surg 1999;15:451-458.

51. Wilson SE. Everett Kinsey Lecture. Keratocyte apoptosis in refractive surgery. CLAO J 1998;24:181-185.

52. Lohmann CP Guell JL Regression after LASIK for the treatment of myopia: the role of the corneal epithelium. Semin Ophthalmol 1998;13:79-82.

53. Maldonado MJ Ruiz-Oblitas L Munuera JM Aliseda D Garcia-Layana A Moreno-Montanes J. Optical coherence tomography evaluation of the corneal cap and stromal bed features after laser in situ keratomileusis for high myopia and astigmatism. Ophthalmology 2000;107:81-87.

54. Joo CK Kim TG. Corneal ectasia detected after laser in situ keratomileusis for correction of less than -12 diopters of myopia. J Cataract Refract Surg 2000;26:292-295.

55. Speicher L G?ttinger W. Progressive corneal ectasia after laser in situ keratomileusis (LASIK). Klin Monatsbl Augenheilkd 1998;213:247-251.

56. Seuer T Quurke AW. Iatrogenic keratectasia after LASIK in a case of forme fruste keratoconus. J Cataract Refract Surg 1998;24:1007-1009.

57. Geggel HS Talley AR. Delayed onset keratectasia following laser in situ keratomileusis. J Cataract Refract Surg 1999;25:582-586.

58. Probst LE Machat JJ. Mathematics of laser in situ keratomileusis for high myopia. J Cataract Refract Surg 1998;24:190-195.

59. Liu Z Huang AJ Pflugfelder SC. Evaluation of corneal thickness and topography in normal eyes using the Orbscan corneal topography system. Br J Ophthalmol 1999;83: 774-778.

60. Srivannaboon S Reinstein DZ Sutton HF Holland SP. Accuracy of Orbscan total optical power maps in detecting refractive change after myopic laser in situ keratomileusis. J Cataract Refract Surg 1999;25:1596-1599.

61. Auffarth GU Wang L Volcker HE. Keratoconus evaluation using the Orbscan Topography System. J Cataract Refract Surg 2000;26:222-228.

62. Kang SW Chung ES Kim WJ. Oinical analysis of central islands after laser in situ keratomileusis. J Cataract Refract Surg 2000;26:536-542.

63. Wang Z Chen J Yang B. Posterior corneal surface topographic changes after laser in situ keratomileusis are related to residual corneal bed thickness. Ophthalmology 1999;106:406-409.

64. Maloney RK Editorial: Posterior corneal surface topographic changes after laser in situ keratomieusis are related to residual corneal bed thickness. Ophthalmology 1999;106:409-410.

65. Wilson SE. Cautions regarding measurements of the posterior corneal curvature. Ophthalmology 2000;107:1223.

66. Lindstrom RL Hardten DR Houtman DM Witte B Preschei N Chu YR Samuelson TW Linebarger EJ. Sixmonth results of hyperopic and astigmatic LASHC in eyes with primary and secondary hyperopia. Trans Am Ophthalmol Soc 1999;97:241-255.

67. Aras C Ozdamar A Bahcecioglu H Karacorlu M Sener B Ozkan S. Decreased tear secretion after laser in situ keratomileusis for high myopia. J Refract Surg 2000; 16: 362-364.

68. Perez-Santonja JJ Sakla HF Cardona C Chipont E AUo JL. Corneal sensitivity after photorefractive keratectomy and laser in situ keratomileusis for low myopia. Am J Ophthalmol 1999;127:497-504.

69. Linna TU Vesaluoma MH P?rez Santonja JJ PetroU WM Ali? JL Tervo TM. Effect of myopic LASIK on corneal sensitivity and morphology of subbasal nerves. Invest Ophthalmol Vis Sci 2000;41:393-397.

70. Beuerman RW Schimmelpfennig B. Sensory denervation of the rabbit cornea affects epitheUal properties. Exp Neurol 1980;69:196.

71. Smith RJ Maloney RK. Diffuse lamellar keratitis. Ophthalmology 1998;105:1721-1726.

72. Fraenkel GE Cohen PR Sutton GL Lawless MA Rogers CM. Central focal interface opacity after laser in situ keratomileusis. J Refract Surg 1998;14:571-576.

73. Kaufman SC Maitchouk DY Chiou AGY Beuerman RW. Interface inflammation after laser in situ keratomileusis. J Cataract Refract Surg 1998;24:1589-1593.

74. Probst LE. Complex Cases in Refractive Surgery. Thorofare NJ: SLACK Ine; 1999.

75. Linebarger EJ Hardten DR Lindstrom RL. Diffuse lamellar keratitis: diagnosis and management. J Cataract Refract Surg 2000;26:1072-1077.

76. Holland SP. Update in cornea and external disease: solving the mystery of "sands of the Sahara" syndrome (diffuse lameUar keratitis). Can J Ophthalmol 1999;34:193-194.

77. Holland SP Mathias RG Morck DW Chi? J Slade SG. Diffuse lameUar keratitis related to endotoxins released from sterilizer reservoir biofilms. Ophthalmology 2000;107:1227-1233.

78. Steinert RF McColgin AZ White A Horsburgh GM. Diffuse interface keratitis after laser in situ keratomileusis (IxASIK): a nonspecific syndrome. Am J Ophthalmol 2000;129:380-381.

79. Waring GO 3rd Carr JD Stulting RD Thompson KP. Prospective randomized comparison of simultaneous and sequential bilateral LASIK for the correction of myopia. Trans Am Ophthalmol Soc 1997;95:271-284.

80. Hovanesian JA Faktorovich EG Hoffbauer JD Shah SS Maloney RK Bilateral bacterial keratitis after laser in situ keratomileusis in a patient with human immunodeficiency virus infection. Arch Ophthalmol 1999;117:968-970.

81. Watanabe H Sato S Maeda N Inoue Y Shimomura Y Tano Y. Bilateral corneal infection as a complication of laser in situ keratomileusis. Arch Ophthalmol 1997;115:1593-1594.

82. Quiros PA Chuck RS Smith RE Irvine JA McDonnell JP Chao LC McDonnell PJ. Infectious ulcerative keratitis after laser in situ keratomUeusis. Arch Ophthalmol 1999;117:1423-1427.

83. Davidorf JM. Herpes simplex keratitis after LASIK [letterj. J Refract Surg 1998;14:667.

84. Webber SK Lawless MA Sutton GL Rogers CM. Staphylococcal infection under a LASIK flap. Cornea 1999;18:361-365.

85. Dada T Sharma N Dada VK Vajpayee RB. Pneumococcal keratitis after laser in situ keratomileusis. J Cataract Refract Surg 2000;26:460-461.

86. Kim HM Song JS Han HS Jung HR. Streptococcal keratitis after myopic laser in situ keratomileusis. Korean J Ophthalmol 1998;12:108-111.

87. Chung MS Goldstein MH Driebe WT Jr Schwartz BH. Mycobacterium chelonae keratitis after laser in situ keratomileusis successfully treated with medical therapy and flap removal. Am J Ophthalmol 2000;129:382-384.

88. Gelender H Carter HL Bowman B Beebe WE Walters GR. Mycobacterium keratitis after laser in situ keratomileusis. J Refract Surg 2000;16:191-195.

89. Reviglio V Rodriguez ML Picotti GS ParadeUo M Luna JD Juarez CP. Mycobacterium chelonae keratitis foUowing laser in situ keratomileusis. J Refract Surg 1998; 14: 357-360.

90. Sridhar MS Garg P Bansal AK Sharma S. Fungal keratitis after laser in situ keratomileusis. J Cataract Refract Surg 2000;26:613-615.

91. Chung MS Goldstein MH Driebe WT Jr Schwartz B. Fungal keratitis after laser in situ keratomileusis: a case report. Cornea 2000;19:236-237.

92. Read RW Chuck RS Rao NA Smith RE. Traumatic Acremonium atrogriseum keratitis following laser-assisted in situ keratomileusis. Arch Ophthalmol 2000;118:418-421.

93. Perez-Santonja JJ Sakla HF Abad JL Zorraquino A Esteban J Alio JL. Nocardial keratitis after laser in situ keratomileusis. J Refract Surg 1997;13:314-317.

94. Aras C Ozdamar A Bahcecioglu H Sener B. Corneal interface abscess after excimer laser in situ keratomileusis. J Refract Surg 1998;14:156-157.

95. Lam DS Leung AT Wu JT Fan DS Cheng AC Wang Z. Culture-negative ulcerative keratitis after laser in situ keratomileusis. J Cataract Refract Surg 1999;25:1004-1008.

96. Mulhern MG Condon PI O'Keefe M. Endophthalmitis after astigmatic myopic laser in situ keratomileusis. J Cataract Refract Surg 1997;23:948-950.

97. Kwon-Chung KJ Bennett JE. Infections due to misceUaneous molds. In: Medical Mycology. Philadelphia PA: Lea & Febiger; 1992:743-753.

98. Rosa RH Jr Miller D Alfonso EC. The changing spectrum of fungal keratitis in south Florida. Ophthalmology 1994;101:1005-1013.

99. Sridhar MS Sharma S Reddy MK Mruthyunjay P Rao GN. CUnicomicrobiological review of Nocardia keratitis. Cornea 1998;17:17-22.

100. Nascimento EG Carvalho MJ de Freitas D Campos M. Nocardial keratitis following myopic keratomileusis. J Refract Surg 1995;11:210-211.

101. Bullington RH Jr Lanier JD Font RL. Nontuberculous mycobacterial keratitis. Report of two cases and review of the literature. Arch Ophthalmol 1992;110:519-524.

102. Pepose JS Laycock KA Miller JK Chansue E Lenze EJ Gans LA Smith ME. Reactivation of latent herpes simplex virus by excimer laser photokeratectomy. Am J Ophthalmol 1992;114:45-50.

103. Tervo T Tuunanen T. Excimer laser and reactivation of herpes simplex keratitis. CLAO J 1994;20:152-153.

104. Vrabec MP Anderson JA Rock ME Binder PS Steinert RF Durrie DS Chase DS. Electron microscopic findings in a cornea with recurrence of herpes simplex keratitis after excimer laser phototherapeutic keratectomy. CLAO J 1994;20:41-44.

105. Dhaliwal DK Barnhorst DA Jr Romanowski E Rehkopf PG Gordon YJ. Efficient reactivation of latent herpes simplex virus type 1 infection by excimer laser keratectomy in the experimental rabbit ocular model. Am J Ophthalmol 1998 125:488-492.

106. DhaUwal DK Romanowski EG Yates KA Barnhorst DA Goldstein M Deeter RG Fish DN Gordon YJ. Valacyclovir inhibits recovery of ocular HSV-I after experimental reactivation by excimer laser keratectomy. Cornea 1999;18: 693-699.

107. Wulff K Fechner PU. Herpes simplex keratitis after photorefractive keratectomy. J Refract Surg 1997; 13:613.

108. Bialasiewicz AA Schaudig U Draeger J Richard G Knobel H. Descemetocele after excimer laser phototherapeutic keratectomy in herpes simplex virus-induced keratitis: a clinico-pathologic correlation. Klin Monatsbl Augenheilkd 1996;208:120-123.

109. Mansour AM Ojeimi GK Premacular subhyaloid hemorrhage following laser in situ keratomileusis. J Refract Surg 2000;16:371-372.

110. Luna JD Reviglio VE Ju?rez CP. Bilateral macular hemorrhage after laser in situ keratomileusis. Graefes Arch Clin Exp Ophthalmol 1999;237:611-613.

111. Ruiz Moreno JM P?rez Santonja JJ Ali? JL. Retinal detachment in myopic eyes after laser in situ keratomileusis. Am J Ophthalmol 1999;128:588-594.

112. Aras C Ozdamar A Karacorlu M Sener B Bahcecioglu H. Retinal detachment following laser in situ keratomileusis. Ophthalmic Surg Lasers 2000;31:121-125.

113. Curtin BJ. The Myopias. Philadelphia PA: Harper & Row; 1985:334.

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Journal of Refractive Surgery

Tập 17 Số 3

350-379

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