Complicated behavior of G-quadruplexes and evaluating G-quadruplexes' ligands in various systems mimicking cellular circumstance

Biochemistry and Biophysics Reports - Tập 5 - Trang 439-447 - 2016
Shi-Ke Wang1, Hua-Fei Su1, Yu-Chao Gu1, Shu-Ling Lin1, Jia-Heng Tan1, Zhi-Shu Huang1, Tian-Miao Ou1
1School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou University City, 132 Waihuan East Road, Guangzhou 510006, PR China

Tài liệu tham khảo

Dexheimer, 2009, NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III(1), Mol. Cancer Ther., 8, 1363, 10.1158/1535-7163.MCT-08-1093 Kumari, 2007, An RNA G-quadruplex in the 5’ UTR of the NRAS proto-oncogene modulates translation, Nat. Chem. Biol., 3, 218, 10.1038/nchembio864 Blackburn, 2001, Switching and signaling at the telomere, Cell, 106, 661, 10.1016/S0092-8674(01)00492-5 Balasubramanian, 2011, Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?, Nat. Rev. Drug Discov., 10, 261, 10.1038/nrd3428 Balasubramanian, 2009, G-quadruplex nucleic acids as therapeutic targets, Curr. Opin. Chem. Biol., 13, 345, 10.1016/j.cbpa.2009.04.637 Reed, 2006, Stabilization of G-quadruplex DNA and inhibition of telomerase activity by square-planar nickel(II) complexes, J. Am. Chem. Soc., 128, 5992, 10.1021/ja058509n Luu, 2006, Structure of the human telomere in K+ solution: an intramolecular (3+1) G-quadruplex scaffold, J. Am. Chem. Soc., 128, 9963, 10.1021/ja062791w Ambrus, 2006, Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution, Nucleic Acids Res., 34, 2723, 10.1093/nar/gkl348 Kan, 2006, Molecular crowding induces telomere G-quadruplex formation under salt-deficient conditions and enhances its competition with duplex formation, Angew. Chem., 45, 1629, 10.1002/anie.200502960 Miller, 2010, Hydration is a major determinant of the G-quadruplex stability and conformation of the human telomere 3’ sequence of d(AG3(TTAG3)3, J. Am. Chem. Soc., 132, 17105, 10.1021/ja105259m Kumar, 2005, The effect of osmolytes and small molecule on Quadruplex-WC duplex equilibrium: a fluorescence resonance energy transfer study, Nucleic Acids Res., 33, 6723, 10.1093/nar/gki961 Heddi, 2011, Structure of human telomeric DNA in crowded solution, J. Am. Chem. Soc., 133, 9824, 10.1021/ja200786q Zheng, 2010, Molecular crowding creates an essential environment for the formation of stable G-quadruplexes in long double-stranded DNA, Nucleic Acids Res., 38, 327, 10.1093/nar/gkp898 Xue, 2007, Human telomeric DNA forms parallel-stranded intramolecular G-quadruplex in K+ solution under molecular crowding condition, J. Am. Chem. Soc., 129, 11185, 10.1021/ja0730462 Miyoshi, 2006, Hydration regulates thermodynamics of G-quadruplex formation under molecular crowding conditions, J. Am. Chem. Soc., 128, 7957, 10.1021/ja061267m Miyoshi, 2004, Duplex dissociation of telomere DNAs induced by molecular crowding, J. Am. Chem. Soc., 126, 165, 10.1021/ja036721q Hansel, 2011, The parallel G-quadruplex structure of vertebrate telomeric repeat sequences is not the preferred folding topology under physiological conditions, Nucleic Acids Res., 39, 5768, 10.1093/nar/gkr174 Chen, 2009, Reduced or diminished stabilization of the telomere G-quadruplex and inhibition of telomerase by small chemical ligands under molecular crowding condition, J. Am. Chem. Soc., 131, 10430, 10.1021/ja9010749 Fry, 2007, Tetraplex DNA and its interacting proteins, Front. Biosci.: J. Virtual Libr., 12, 4336, 10.2741/2391 Izbicka, 1999, Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells, Cancer Res., 59, 639 Ou, 2007, Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives, J. Med. Chem., 50, 1465, 10.1021/jm0610088 Zhou, 2005, Synthesis and evaluation of quindoline derivatives as G-quadruplex inducing and stabilizing ligands and potential inhibitors of telomerase, J. Med. Chem., 48, 7315, 10.1021/jm050041b Lu, 2008, 5-N-methylated quindoline derivatives as telomeric g-quadruplex stabilizing ligands: effects of 5-N positive charge on quadruplex binding affinity and cell proliferation, J. Med. Chem., 51, 6381, 10.1021/jm800497p Tan, 2009, Isaindigotone derivatives: a new class of highly selective ligands for telomeric G-quadruplex DNA, J. Med. Chem., 52, 2825, 10.1021/jm801600m Liu, 1996, Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c, Cell, 86, 147, 10.1016/S0092-8674(00)80085-9 Leoni, 1998, Induction of an apoptotic program in cell-free extracts by 2-chloro-2’-deoxyadenosine 5’-triphosphate and cytochrome c, Proc. Natl. Acad. Sci. USA, 95, 9567, 10.1073/pnas.95.16.9567 De Cian, 2007, Fluorescence-based melting assays for studying quadruplex ligands, Methods, 42, 183, 10.1016/j.ymeth.2006.10.004 Kypr, 2009, Circular dichroism and conformational polymorphism of DNA, Nucleic Acids Res., 37, 1713, 10.1093/nar/gkp026 Han, 1999, A DNA polymerase stop assay for G-quadruplex-interactive compounds, Nucleic Acids Res., 27, 537, 10.1093/nar/27.2.537 Thakur, 2009, Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression, Nucleic Acids Res., 37, 172, 10.1093/nar/gkn919 Wienken, 2011, Thermophoretic melting curves quantify the conformation and stability of RNA and DNA, Nucleic Acids Res., 39, e52, 10.1093/nar/gkr035