Sự Phức Tạp Trong Di Truyền Của Viêm Khớp Psoriatic

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North Am. 2015b;41(4):623–42 This review provides a summary of differential expressed genes, epigenetics and pharmacogenetics of psoriatic disease as well as genetic susceptibiltiy of psoriasis and psoraitic arthritis. •• Stuart, P. E, Tsoi, L. C, Hambro, C. A, Elder, J. T. Genetics of psoriasis. In: Fitzgerald O, Gladman D, editors. Oxford Textb. Psoriatic Arthritis. 1st ed. 2019b. p. 35–55. Exhaustive reivew of psoriasis with comprehensive list of susceptibility loci in psoriasis. Winchester R, O’Reilly, D P R. Genetics of psoriatic arthritis. In: FitzGerard O, Gladman D, editors. Oxford Textb. Psoriatic Arthritis. 2019a. p. 57–67. • Winchester R, O’Reilly D. P R. genetics of psoriatic arthritis. In: Oxford Textb. Psoriatic arthritis. Fitzgerard O, Gladman D ed; 2019b. p. 57–67. A very practical review of the MHC associations and non-mHC associations in psoriatic arthritis. 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Available from: http://nar.oxfordjournals.org/lookup/doi/10.1093/nar/gku1179 Patrick MT, Stuart PE, Raja K, Gudjonsson JE, Tejasvi T, Yang J, et al. Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients. Nat. Commun. 2018a;9(1). Stuart PE, Nair RP, Tsoi LC, Tejasvi T, Das S, Kang HM, et al. Genome-wide association analysis of psoriatic arthritis and cutaneous psoriasis reveals differences in their genetic architecture. Am J Hum Genet. 2015a;97(6):816–36. •• Patrick MT, Stuart PE, Raja K, Gudjonsson JE, Tejasvi T, Yang J, et al. Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients. Nat. Commun. 2018b;9(1) Using machine learning methodology differences in genetic architecture between psoriasis subtypes were interrogated to develop risk assessment models for PsA. •• Stuart PE, Nair RP, Tsoi LC, Tejasvi T, Das S, Kang HM, et al. Genome-wide association analysis of psoriatic arthritis and cutaneous psoriasis reveals differences in their genetic architecture. Am. J. Hum. Genet. 2015b;97(6):816–36 PsA GWAS followed by meta-analysis of other large datasets identified multiple significant loci and differences in various genetic loci were noted between cutanous psoriasis and PsA.