Complexation of Vinpocetine with Cyclodextrins in the Presence or Absence of Polymers. Binary and Ternary Complexes Preparation and Characterization
Tóm tắt
Inclusion complexation between β-cyclodextrin (β-CD),hydroxypropyl-β-cyclodextrin (HP-β-CD), water-solublepolymers (PVP and HPMC) and vinpocetine was studied in aqueous solution and in the solid state.Phase solubility studies were used to evaluate the complexation in aqueous solution at roomtemperature. Stability constants (Kc) of binary and ternary complexes were determined spectrophotometrically. Differential scanning calorimetry (DSC)was used to characterize kneaded, co-evaporated and lyophilised binary and ternary systems.The Kc values obtained were 70.14 M-1 and 35.01 M-1 for vinpocetine-β-CD and vinpocetine-HP-β-CD and increased in a range of 17% to 94%by addition of water-soluble polymers. Some preliminary evidences ofinclusion complexation were obtained from DSC suggesting that co-evaporated and lyophilised binary andternary systems were truly inclusion complexes.
Tài liệu tham khảo
K.H. Frömming and J. Szejtli: in K.H. Frömming and J. Szejtli (eds.), Cyclodextrins Inclusion Complexes (Cyclodextrin in Pharmacy), Vol. 5, Kluwer Academic Publishers, Dordrecht, pp. 45–81 (1994).
T. Loftsson, M. Másson and J.F. Sigurjó nsdó ttir: S.T.P. Pharma Sciences 9, 237 (1999).
T. Loftsson: Pharmazie 53, 733 (1998).
P. Bönöczk, B. Gulyás, V. Adam-Vizi, A. Nemes, Kárpáti, B. Kiss, M. Kapás, C. Szántay, I. Koncz, T. Zelles and A. Vas: Brain Research Bulletin 53, 245 (2000).
T. Higuchi and K.A. Connors: in C.N. Reill (ed.), Phase-Solubility Techniques (Advances in Analytical Chemistry and Instrumentation, Wiley-Intersciences, New York, pp. 117–212 (1965).
T. Loftsson and H. Fridriksdó ttir: International Journal of Pharmaceutics 163, 115 (1998).
A. Yoshida, M. Yamamoto, T. Irie, F. Hirayama and K. Uekama: Chemical and Pharmaceutical Bulletin 37, 1059 (1989).
F. Giordano, C. Novak and J.R. Moyano: Thermochimica Acta 380, 123 (2001).
P. Mura, M.T. Faucci and G.P. Bettinetti: European Journal of Pharmaceutical Sciences 13, 187 (2001).
G. Dollo, P. Le Corre, M. Chollet, F. Chevanne, M. Bertault, J.L. Burgot and R. Le Verge: Journal of Pharmaceutical Sciences 88, 889 (1999).
G.P. Bettinetti, A. Gazzaniga, P. Mura, F. Giordano and M. Setti: Drug Development and Industrial Pharmacy 18, 39 (1992).
P. Mura, M.T. Faucci, P.L. Parrini, S. Furlanetto and S. Pinzauti: International Journal of Pharmaceutics 179, 117 (1998).
J. Savolainen, K. Jarvinen, H. Taipale, P. Jarho, T. Loftsson and T. Jarvinen: Pharmaceutical Research 15, 1696 (1998).
B. Cappello, C. Carmignani, M. Iervolino, M.I. La Rotonda and M.F. Saettone: International Journal of Pharmaceutics 213, 75 (2001).
H. Fridriksdó ttir, T. Loftsson and E. Stefánsson: Journal of Controlled Release 44, 95 (1997).
H. Fridriksdó ttir, T. Loftsson, J.A. Gudmundsson, G.J. Bjarnason, M. Kjeld and T. Thorsteinsson: Pharmazie 51, 39 (1996).