Complex Brugada syndrome inheritance in a family harbouring compound SCN5A and CACNA1C mutations

Delphine Béziau1,2,3,4, Julien Barc2,4,3, Thomas O’Hara5, Laurianne Le Gloan2,3,4, Mohamed Yassine Amarouch2,3,4,6, Aude Solnon7,8,9, Dominique Pavin8,7,10, Simon Lecointe2,3,4, Patricia Bouillet10,7,8, Jean‐Luc Pasquié2,3,4, Pascale Guicheney11,12, Isabelle Denjoy13,12,11, Richard Redon2,3,4, Philippe Mabo7,8,9, Hervé Le Marec2,3,4, Gildas Loussouarn2,3,4, Florence Kyndt14,4,3,2, Jean‐Jacques Schott2,3,4, Vincent Probst2,3,4, Isabelle Baró2,3,4
1Montreal Heart Institute, Montréal, Canada
2CNRS, UMR 6291, Nantes, France
3Université de Nantes, Nantes, France
4INSERM, UMR 1087, l’institut du thorax, Nantes cedex 1, France
5Institute for Computational Medicine, Department of Biomedical Engineering, Johns Hopkins University, Baltimore, USA
6Environment & Natural Substances Laboratory, Multidisciplinary Faculty of Taza, University of Sidi Mohamed Ben Abdellah- Fes, Taza, Morocco
7Département de cardiologie et des maladies vasculaires, Centre Hospitalo-Universitaire de Rennes, Rennes, France
8INSERM, U642, Rennes, France
9Université de Rennes 1, Rennes, France
10Université de Rennes-1, Rennes, France
11INSERM, UMR_S1166, Paris, France
12Sorbonne Universités, UPMC University of Paris 06, Institute of Cardiometabolism and Nutrition (ICAN), Paris, France
13AP-HP, Hôpital Bichat, Département de Cardiologie, Centre de Référence des Maladies Cardiaques Héréditaires, Paris, France
14CHU Nantes, Service de Génétique Médicale, Nantes, France

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