Complement as a mediator of allograft injury: an inflammatory view

Transplantation Reviews - Tập 14 - Trang 41-51 - 2000
William M. Baldwin1, Milagros Samaniego1, Zhiping Qian1, Hirofumi Ota1, Barbara A. Wasowska1, Fred Sanfilippo1, Ralph H. Hruban1
1From the Department of Pathology, The Johns Hopkins University, Baltimore, MD, USA

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Wetsel, 1995, Structure, function and cellular expression of complement anaphylatoxin receptors, Curr Opin Immunol, 7, 48, 10.1016/0952-7915(95)80028-X Martin, 1997, The human C3a receptor is expressed on neutrophils and monocytes, but not on B or T lymphocytes, J Exp Med, 86, 199, 10.1084/jem.186.2.199 Barton, 1993, Complement component C5 modulates the systemic tumor necrosis factor response in murine endotoxic shock, Infect Immun, 61, 1474, 10.1128/IAI.61.4.1474-1481.1993 Morgan, 1993, Anti-C5a receptor antibodies: Characterization of neutralizing antibodies specific for a peptide: C5aR-(9-29), derived from the predicted amino-terminal sequence of the human C5a receptor, J Immunol, 151, 377, 10.4049/jimmunol.151.1.377 Ember, 1994, Induction of interleukin-8 synthesis from monocytes by human C5a anaphylatoxin, Am J Pathol, 144, 393 Arnaout, 1984, Deficiency of a leukocyte surface glycoprotein (LFA-1) in two patients with Mol deficiency: Effects of cell activation on Mol/LFA-1 surface expression in normal and deficient leukocytes, J Clin Invest, 74, 1291, 10.1172/JCI111539 Fearon, 1983, Increased expression of C3b receptors on polymorphonuclear leukocytes induced by chemotactic factors and by purification procedures, J Immunol, 130, 370, 10.4049/jimmunol.130.1.370 Werfel, 1992, Binding of fluorescein-labeled anaphylatoxin C5a to human peripheral blood, spleen, and bone marrow leukocytes, Blood, 79, 152, 10.1182/blood.V79.1.152.152 Wahlin, 1983, C3 receptors on uman lymphocyte subsets and recruitment of ADCC effector cells by C3 fragments, J Immunol, 130, 2831, 10.4049/jimmunol.130.6.2831 Tedesco, 1997, The cytolytically inactive terminal complement complex activates endothelialcells to express adhesion molecules and tissue factor procoagulant activity, J Exp Med, 185, 1619, 10.1084/jem.185.9.1619 Torzewski, 1996, Complement-induced release of monocyte chemotactic protein-1 from human smooth muscle cells: A possible initiating event in atherosclerotic lesion formation, Arterioscler Thromb Vasc Biol, 16, 673, 10.1161/01.ATV.16.5.673 Kilgore, 1996, The membrane attack complex of complement induces interleukin-8 and monocyte chemoattractant protein-1 secretion from human umbilical vein endothelial cells, Am J Pathol, 149, 953 Carroll, 1988, Organization of the genes encoding complement receptors type 1 and 2, decay-accelerating factor, and C4-binding protein in the RCA locus on human chromosome 1, J Exp Med, 167, 1271, 10.1084/jem.167.4.1271 Liszewski, 1991, Membrane cofactor protein (MCP or CD46): Newest member of the regulators of complement activation gene cluster, Annu Rev Immunol, 9, 431, 10.1146/annurev.iy.09.040191.002243 Ollert, 1994, Antibody-mediated complement activation on nucleated cells. A quantitative analysis of the individual reaction steps, J Immunol, 153, 2213, 10.4049/jimmunol.153.5.2213 Johnson, 1988, Mononuclear phagocytes have the potential to synthesize the complete functional complement system, Scand J Immunol, 27, 489, 10.1111/j.1365-3083.1988.tb02375.x Botto, 1992, Biosynthesis and secretion of complement component (C3) by activated human polymorphonuclear leukocytes, J Immunol, 149, 1348, 10.4049/jimmunol.149.4.1348 Johnson, 1991, Human umbilical vein endothelial cells synthesize functional C3, C5, , C6, C8 and C9 in vitro, Scand J Immunol, 33, 667, 10.1111/j.1365-3083.1991.tb02539.x Brooimans, 1991, Interleukin-2 mediates stimulation of complement C3 biosynthesis in human proximal tubular epithelial cells, J Clin Invest, 88, 379, 10.1172/JCI115314 Witte, 1991, Detection and cellular localization of human C4 gene expression in the renal tubular epithelial cells and other extrahepatic epithelial sources, Am J Pathol, 139, 717 van den Dobbelstein, 1994, Regulation of C3 and factor H synthesis of human glomerular mesangial cells by IL-1 and interferon-gamma, Clin Exp Immunol, 95, 173, 10.1111/j.1365-2249.1994.tb06033.x Sacks, 1993, C3 and C4 gene expression and interferon-gamma-mediated regulation in human glomerular mesangial cells, Clin Exp Immunol, 93, 411, 10.1111/j.1365-2249.1993.tb08193.x Khirwadkar, 1993, Interleukin-4 augments production of the third complement component by the alveolar epithelial cell line A549, Int Arch Allergy Immunol, 100, 35, 10.1159/000236384 Brooimans, 1990, Differential regulation of complement factor H and C3 production in human umbilical vein endothelial cells by IFN-gamma and IL-1, J Immunol, 144, 3835, 10.4049/jimmunol.144.10.3835 Terasaki, 1995, High survival rates of kidney transplants from spousal and living unrelated donors, N Engl J Med, 333, 333, 10.1056/NEJM199508103330601 Takada, 1998, Effects of explosive brain death on cytokine activation of peripheral organs in the rat, Transplantation, 65, 1533, 10.1097/00007890-199806270-00001 Bittner, 1996, The combined effects of brain death and cardiac graft preservation on cardiopulmonary hemodynamics and function before and after subsequent heart transplantation, J Heart Lung Transplant, 15, 764 Marshall, 1996, Adverse effect of donor vasopressor support on immediate and one-year kidney allograft function, Surgery, 120, 663, 10.1016/S0039-6060(96)80014-6 Herijgers, 1996, Changes in organ perfusion after brain death in the rat and its relation to circulating catecholamines, Transplantation, 62, 330, 10.1097/00007890-199608150-00005 Novitzky, 1997, Ultrastructure changes associated with brain death in the human donor heart, Transpl Int, 10, 24, 10.1111/j.1432-2277.1997.tb00532.x Mollnes, 1997, Biocompatibility: Complement as mediator of tissue damage and as indicator of incompatibility, Exp Clin Immunogenet, 14, 24 Halloran, 1997, The “injury response”: A concept linking non-specific injury, acute rejection, and long-term transplant outcomes, Transplant Proc, 29, 79, 10.1016/S0041-1345(96)00015-2 Maroko, 1978, Reduction by cobra venom factor of myocardial necrosis after coronary artery occlusion, J Clin Invest, 61, 661, 10.1172/JCI108978 Weisman, 1990, Soluble human complement receptor type 1: In vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis, Science, 249, 146, 10.1126/science.2371562 Halloran, 1992, Local T cell responses induce widespread MHC expression: Evidence that INFg induces its own expression in remote sites, J Immunol, 148, 3837, 10.4049/jimmunol.148.12.3837 Kilgore, 1994, The complement system in myocardial ischaemia/reperfusion injury, Cardiovasc Res, 28, 437, 10.1093/cvr/28.4.437 Weiser, 1996, Reperfusion injury of ischemic skeletal muscle is mediated by natural antibody and complement, J Exp Med, 183, 2343, 10.1084/jem.183.5.2343 Kagiyama, 1989, Molecular basis of complement activation in ischemic myocardium: Identification of specific molecules of mitochondrial origin that bind human C1q and fix complement, Circ Res, 64, 607, 10.1161/01.RES.64.3.607 Kovacsovics, 1987, Antibody-independent activation of C1: I. Differences in the mechanism of C1 activation by nonimmune activators and by immune complexes: C1r-independent activation of C1s by cardiolipin vesicles, J Immunol, 138, 1864, 10.4049/jimmunol.138.6.1864 Pemberton, 1993, Microvascular effects of complement blockade with soluble recombinant CR1 on ischemia/reperfusion injury of skeletal muscle, J Immunol, 150, 5104, 10.4049/jimmunol.150.11.5104 Baldwin, 1999, Complement deposition in early cardiac transplant biopsies is associated with ischemic injury and subsequent rejection episodes, Transplantation, 68, 894, 10.1097/00007890-199909270-00024 Qian, 1998, C6 produced by macrophages contributes to cardiac allograft rejection, Transplantation, 65, S77, 10.1097/00007890-199806270-00319 Linas, 1992, Mild renal ischemia activates primed neutrophils to cause acute renal failure, Kidney Int, 42, 610, 10.1038/ki.1992.325 Seekamp, 1993, Requirements for neutrophil products and l-arginine in ischemia-reperfusion injury, Am J Pathol, 142, 1217 Baldwin, 1995, Complement in organ transplantation: Contribution to inflammation, injury and rejection, Transplantation, 59, 797, 10.1097/00007890-199503000-00001 Halloran, 1992, The significance of the anti-class I response: II. Clinical and pathological features of renal transplants with anti-class I-like antibody, Transplantation, 53, 550, 10.1097/00007890-199203000-00011 Lobo, 1995, Evidence demonstrating poor kidney graft survival when acute rejections are associated with IgG donor-specific lymphocytotoxin, Transplantation, 59, 357, 10.1097/00007890-199502150-00009 Feucht, 1996, The humoral immune response towards HLA class II determinants in renal transplantation, Kidney Int, 50, 1464, 10.1038/ki.1996.460 Gracie, 1990, T cell requirements for the rejection of renal allografts bearing an isolated class I MHC disparity, J Exp Med, 172, 1547, 10.1084/jem.172.6.1547 Bradley, 1992, Processed MHC class I alloantigen as the stimulus for CD4+ T-cell dependent antibody-mediated graft rejection, Immunol Today, 13, 434, 10.1016/0167-5699(92)90069-J Brandle, 1998, Contribution of donor-specific antibodies to acute allograft rejection: Evidence from B cell-deficient mice, Transplantation, 65, 1489, 10.1097/00007890-199806150-00014 Wasowska, 1998, Elimination of antibody responses inhibits acute and chronic cardiac allograft rejection in mice, Transplantation, 65, S90, 10.1097/00007890-199806270-00371 Larsen, 1996, CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway, Transplantation, 61, 4, 10.1097/00007890-199601150-00002 Collins, 1993, Cyclosporine and cremaphor modulate von Willebrand factor release from cultured human endothelial cells, Transplantation, 56, 1218, 10.1097/00007890-199311000-00032 Wasowska, 1999, Inhibition of acute cardiac allograft rejection in immunoglobulin-deficient mice, Transplant Proc, 31, 136, 10.1016/S0041-1345(98)01476-6 Wasowska BA, Qian Z, Behrens E, et al: Elimination of antibody responses inhibits acute and chronic cardiac allograft rejection in mice. J Immunol (submitted) Suzuki, 1991, Signal transduction mechanisms through Fc gamma receptors on the mouse macrophage surface, FASEB J, 5, 187, 10.1096/fasebj.5.2.1706281 Ravetch, 1998, Divergent roles for Fc receptors and complement in vivo, Annu Rev Immunol, 16, 421, 10.1146/annurev.immunol.16.1.421 Yamazaki, 1998, Role of selectindependent adhesion in cardiac allograft rejection, J Heart Lung Transplant, 17, 1007 Salom, 1998, Endothelial activation and cytokine expression in human acute cardiac allograft rejection, Pathology, 30, 24, 10.1080/00313029800169625 Saadi, 1995, Complementmediated regulation of tissue factor activity in endothelium, J Exp Med, 182, 1807, 10.1084/jem.182.6.1807 Brauer, 1994, Hepatic and extrahepatic biosynthesis of complement factor C6 in the rat, J Immunol, 153, 3168, 10.4049/jimmunol.153.7.3168 Bradley, 1992, Allograft rejection in CD4+ T cell-reconstituted athymic nude rats—the nonessential role of host-derived CD8+ cells, Transplantation, 53, 477, 10.1097/00007890-199202010-00040 Qian, 1998, Complement contributes to the rejection of complete and class I MHC-incompatible cardiac allografts, J Heart Lung Transplant, 17, 470 Brauer, 1995, The contribution of terminal complement components to acute and hyperacute allograft rejection in the rat, Transplantation, 59, 288, 10.1097/00007890-199501000-00023 Tannenbaum, 1990, Gamma-interferon modulates von Willebrand factor release by cultured human endothelial cells, Blood, 75, 2177, 10.1182/blood.V75.11.2177.2177 Russell, 1996, Accelerated atheromatous lesions in mouse hearts transplanted to apolipoprotein-E-deficient recipients, Am J Pathol, 149, 91 Russell, 1997, Alloantibody- and T cell-mediated immunity in the pathogenesis of transplant arteriosclerosis: Lack of progression to sclerotic lesions in B cell-deficient mice, Transplantation, 64, 1531, 10.1097/00007890-199712150-00005 Shi, 1996, Immunological basis of transplant-associated ateriosclerosis, 93, 4051 Shi, 1994, Murine model of accelerated transplant arteriosclerosis, Circ Res, 75, 199, 10.1161/01.RES.75.2.199 Russell, 1994, Coronary atherosclerosis in transplanted mouse hearts: II. Importance of humoral immunity, J Immunol, 152, 5135, 10.4049/jimmunol.152.10.5135 Brauer, 1993, Rat strain differences in complement activity correlate with hyperacute rejection of guinea pig cardiac xenografts, Transplant Proc, 25, 2848 Brauer, 1993, The use of C6-deficient rats to evaluate the mechanism of hyperacute rejection of discordant cardiac xenografts, J Immunol, 151, 7240, 10.4049/jimmunol.151.12.7240 Qian, 1999, C6 produced by macrophages contributes to cardiac allograft rejection, Am J Pathol, 1293 Benzaquen, 1994, Terminal complement proteins C5b-9 release basic fibroblast growth factor and platelet-derived growth factor from endothelial cells, J Exp Med, 179, 985, 10.1084/jem.179.3.985 Halperin, 1993, Terminal complement complex C5b-C9 stimulates mitogenesis in 3T3 cells, J Clin Invest, 91, 1974, 10.1172/JCI116418 Adams, 1993, Chronic rejection in experimental cardiac transplantation: Studies in the Lewis-F334 model, Immunol Rev, 134, 5, 10.1111/j.1600-065X.1993.tb00637.x Wasowska, 1992, IgG alloantibody responses to donor-specific blood transfusion in different rat strain combinations are predictive of renal allograft survival, Transplantation, 53, 175, 10.1097/00007890-199201000-00035 Wasowska, 1993, The association of enhancement of renal allograft survival by donor-specific blood transfusion with host MHC-linked inhibition of IgG anti-donor class I alloantibody responses, Transplantation, 56, 672, 10.1097/00007890-199309000-00033 Wray, 1992, IgM and IgG alloantibody responses to MHC class I and II following rat renal allograft rejection: Effects of transplantectomy and posttransplantation blood transfusions, Transplantation, 53, 167, 10.1097/00007890-199201000-00034 Wray, 1993, Different patterns of sensitization following renal allograft rejection in an inbred rat strain combination, Transplantation, 55, 1132, 10.1097/00007890-199305000-00038 Moen, 1996, Centrifugal pump and heparin coating improves cardiopulmonary bypass biocompatibility, Ann Thorac Surg, 62, 1134, 10.1016/0003-4975(96)00492-4 Ashraf, 1998, Inflammatory mediators in adults undergoing cardiopulmonary bypas: Comparison of centrifugal and roller pumps, Ann Thorac Surg, 65, 480, 10.1016/S0003-4975(97)01349-0 Rose, 1993, Antibody-mediated rejection following cardiac transplantation, Transplant Rev, 7, 140, 10.1016/S0955-470X(05)80013-8 de Heer, 1994, Chronic renal allograft rejection in the rat. Transplantation-induced antibodies against basement membrane antigens, Lab Invest, 70, 494 Paul, 1995, Chronic renal transplant loss, Kidney Int, 47, 1491, 10.1038/ki.1995.211 Rose, 1996, Role of antibody and indirect antigen presentation in transplant-associated coronary artery vasculopathy, J Heart Lung Transplant, 15, 342 Paul, 1998, Antibodies against mesangial cells and their secretory products in chronic renal allograft rejection in the rat, Am J Pathol, 152, 1209 Samaniego, 1999, Heat shock proteins are the target on immune reactions in warm ischemic injury, Transplantation, 67, S37, 10.1097/00007890-199904150-00150 Davis, 1996, Induction of heat shock protein in a model of acute cardiac allograft rejection, Transplantation, 61, 279, 10.1097/00007890-199601270-00020 Baba, 1997, Inducible heat shock protein 70 in rat cardiac allograft and its immunohistochemical localization in cardiac myocytes, Transplantation, 64, 1035, 10.1097/00007890-199710150-00016 Weiss, 1994, T cells reactive to an inducible heat shock protein induce disease in toxin-induced interstitial nephritis, J Exp Med, 180, 2239, 10.1084/jem.180.6.2239 Van Why, 1994, Activation of heat-shock transcription factor by graded reductions in renal ATP, in vivo, in the rat, J Clin Invest, 94, 1518, 10.1172/JCI117492 Van Why, 1992, Induction and intracellular localization of HSP-72 after renal ischemia, Am J Physiol, 263, F769 Sato, 1996, Expression of heat shock protein on lymphocytes in peripheral blood and synovial fluid from patients with rheumatoid arthritis, J Rheumatol, 23, 2027 Vendetti, 1996, Heat-shock protein expression on the membrane of T cells undergoing apoptosis, Immunology, 88, 6, 10.1046/j.1365-2567.1996.d01-656.x Chicz, 1993, Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles, J Exp Med, 178, 27, 10.1084/jem.178.1.27 Cresswell, 1993, Characterization of endogenous peptides bound to purified HLA-DR molecules and their absence from invariant chain-associated alpha beta dimers, J Immunol, 150, 499, 10.4049/jimmunol.150.2.499 Koga, 1989, T cells against a bacterial heat shock protein recognize stressed macrophages, Science, 245, 1112, 10.1126/science.2788923 Moliterno, 1995, Heat shock protein-induced T-lymphocyte propagation from endomyocardial biopsies in heart transplantation, J Heart Lung Transplant, 14, 329 Liu, 1996, Role of heat shock proteins in heart transplant rejection, J Heart Lung Transplant, 15, 222 Trieb, 1996, T cells from rejected human kidney allografts respond to heat shock protein 72, Transpl Immunol, 4, 43, 10.1016/S0966-3274(96)80032-3 Baldwin, 1999, Complement in graft injury, Graft, 2