Complement Membrane Attack Complex

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Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence, Nature, 459, 433, 10.1038/nature07965 Scolding, 1989, Vesicular removal by oligodendrocytes of membrane attack complexes formed by activated complement, Nature, 339, 620, 10.1038/339620a0 Sims, 1986, Repolarization of the membrane potential of blood platelets after complement damage: evidence for a Ca++ -dependent exocytotic elimination of C5b-9 pores, Blood, 68, 556, 10.1182/blood.V68.2.556.556 Moskovich, 2007, Live cell imaging of outward and inward vesiculation induced by the complement c5b-9 complex, J Biol Chem, 282, 29977, 10.1074/jbc.M703742200 Stein, 1991, Ectocytosis caused by sublytic autologous complement attack on human neutrophils: the sorting of endogenous plasma-membrane proteins and lipids into shed vesicles, Biochem J, 274, 381, 10.1042/bj2740381 Moskovich, 2012, Caveolin-1 and dynamin-2 are essential for removal of the complement C5b-9 complex via endocytosis, J Biol Chem, 287, 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Membrane attack complex (mac) deposition in lupus nephritis is associated with hypertension and poor clinical response to treatment, Semin Arthritis Rheum, 48, 256, 10.1016/j.semarthrit.2018.01.004 Alegretti, 2010, Expression of CD55 and CD59 on peripheral blood cells from systemic lupus erythematosus (SLE) patients, Cell Immunol, 265, 127, 10.1016/j.cellimm.2010.07.013 Cohen, 2017, Brain histopathology in patients with systemic lupus erythematosus: identification of lesions associated with clinical neuropsychiatric lupus syndromes and the role of complement, Rheumatology (Oxford), 56, 77, 10.1093/rheumatology/kew341 Holers, 2018, Complement in the initiation and evolution of rheumatoid arthritis, Front Immunol, 9, 1057, 10.3389/fimmu.2018.01057 Morgan, 1988, Measurement of terminal complement complexes in rheumatoid arthritis, Clin Exp Immunol, 73, 473 Corallini, 2009, The soluble terminal complement complex (SC5b-9) up-regulates osteoprotegerin expression and release by endothelial 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