Comparison of the solubility and pharmacokinetics of sildenafil salts

Amidon, G. L., Lennernas, H., Shah, V. P., and Crison, J. R., A theoretical basis for a biopharmaceutics durg classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm. Res., 12, 413–420 (1995).

Boolell, M., Gepi-Attee, S., Gingell, J. C., and Allen, M. J., Sildenafil, a novel effective oral therapy for male erectile dysfunction. Br. J. Urol., 184, 63–72 (1996).

Choi, H. G., Oh, Y. K., and Kim, C. K., In situ gelling and mucoadhesive liquid suppository containing acetaminophen: enhanced bioavailability. Int. J. Pharm., 165, 23–32 (1998).

Choi, H. G., Lee, B. J., Yong, C. S., Rhee, J. D., Han, J. H., Lee, M. K., Park, K. M., and Kim, C. K., Terfenadine-β-cyclodextrin inclusion complex with the anti-histaminic activity enhancement. Drug Dev. Ind. Pharm., 27, 857–862 (2007).

Eardly, I., Ellis, P., Boolell, M., and Wulff, M., Onset and duration of action of sildenafil citrate treatment of erectile dysfunction. Br. J. Clin. Pharmacol., 53, 61S–65S (2002).

Elshafeey, A. H., Bendas, E. R., and Mohamed, O. H., Intranasal microemulsion of sildenafil citrate: in vitro evaluation and in vivo pharmacokinetic study in rabbits. AAPS PharmSciTech, 10, 361–367 (2009).

Gibaldi, M. and Perrier, D., Pharmacokinetics, 2nd ed. Marcel-Dekker, New York, (1982).

Gratz, S. R., Flurer, C. L., and Wolnik, K. A., Analysis of undeclared synthetic phosphodiesterase-5 inhibitors in dietary supplements and herbal matrices by LC-ESI-MS and LC-UV. J. Pharm. Biomed. Anal., 36, 525–533 (2004).

Gupta, M., Kovar, A., and Meibohm, B., The clinical pharmacokinetics of phosphodiesterase-5 inhibitors for erectile dysfunction. J. Clin. Pharmacol., 45, 987–1003 (2005).

Li, D. X., Oh, Y. K., Lim, S. J., Kim, J. O., Yang, H. J., Sung, J. H., Yong, C. S., and Choi, H. G., Novel gelatin microcapsule with bioavailability enhancement of ibuprofen using spray drying technique. Int. J. Pharm., 355, 277–284 (2008).

Quintero, A., Caldera, A., Milano, B., Odreman, I., Hurtado, A., Manzanares, L., and Villamizar, J., Validation of an HPLC method for sildenafil citrate analysis in human plasma samples. Pharmazie, 64, 796–799 (2009).

Shin, H. S., Bae, S. K., and Lee, M. G., Pharmacokinetics of sildenafil after intravenous and oral administration in rats: hepatic and intestinal first-pass effects. Int. J. Pharm., 320, 64–70 (2006).

Society of Toxicology (SOT), Guiding Principles in the Use of Animals in Toxicology (2008): www.toxicology.org/AI/FA/guidingprinciples.pdf .

Wang, Y., Chow, M. S., and Zuo, Z., Mechanistic analysis of pH-dependent solubility and trans-membrane permeability of amphoteric compounds: application to sildenafil. Int. J. Pharm., 352, 217–224 (2008).

Yong, C. S., Yang, C. H., Rhee, J. D., Lee, B. J., Kim, D. C., Kim, D. D., Kim, C. K., Choi, J. S., and Choi, H. G., Enhanced rectal bioavailability of ibuprofen in rats by poloxamer 188 and menthol. Int. J. Pharm., 269, 169–176 (2004).