Comparison of analytical methods for antibody conjugates with application in nuclear imaging – Report from the trenches

Nuclear Medicine and Biology - Tập 102 - Trang 24-33 - 2021
Irene V.J. Feiner1, Beatrice Longo2, Vanessa Gómez-Vallejo1, Javier Calvo1, Marion Chomet3, Danielle J. Vugts3, Albert D. Windhorst3, Daniel Padro1, Matteo Zanda2,4, Luka Rejc5, Jordi Llop1,6
1CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo Miramon 182, 20014 San Sebastian, Spain
2Kosterlitz Centre for Therapeutics, University of Aberdeen, UK
3Amsterdam UMC, VU University, Dept. of Radiology and Nuclear Medicine, De Boelelaan 1085c, 1117 HV Amsterdam, the Netherlands
4CNR-SCITEC, via Mancinelli 7, 20131 Milan, Italy
5University of Ljubljana, Faculty of Chemistry and Chemical Technology, Večna pot 113, 1000, Ljubljana, Slovenia
6Centro de Investigación Biomédica en Red – Enfermedades Respiratorias (CIBERES), Spain

Tài liệu tham khảo

Beck, 2017, Strategies and challenges for the next generation of antibody-drug conjugates, Nat Rev Drug Discov, 16, 315, 10.1038/nrd.2016.268 Khongorzul, 2020, Antibody-drug conjugates: a comprehensive review, Mol Cancer Res, 18, 3, 10.1158/1541-7786.MCR-19-0582 Aluicio-Sarduy, 2018, PET radiometals for antibody labeling, J Label Compd Radiopharm, 61, 636, 10.1002/jlcr.3607 Morais, 2018, Site-specific chelator-antibody conjugation for PET and SPECT imaging with radiometals, Drug Discov Today Technol, 30, 91, 10.1016/j.ddtec.2018.10.002 Xing, 2019, Early phase I study of a 99mTc-labeled anti-programmed death ligand-1 (PD-L1) single-domain antibody in SPECT/CT assessment of PD-L1 expression in non-small cell lung cancer, J Nucl Med, 60, 1213, 10.2967/jnumed.118.224170 Vira, 2010, Fluorescent-labeled antibodies: balancing functionality and degree of labeling, Anal Biochem, 402, 146, 10.1016/j.ab.2010.03.036 Gupta, 2017, Assessment of near-infrared fluorophores to study the biodistribution and tumor targeting of an IL13 receptor a2 antibody by fluorescence molecular tomography, Oncotarget, 8, 57231, 10.18632/oncotarget.19569 Meyer, 2016, Click chemistry and radiochemistry: the first 10 years, Bioconjug Chem, 27, 2791, 10.1021/acs.bioconjchem.6b00561 Massa, 2016, Emerging site-specific bioconjugation strategies for radioimmunotracer development, Expert Opin Drug Deliv, 13, 1149, 10.1080/17425247.2016.1178235 Yamada, 2019, Recent chemical approaches for site-specific conjugation of native antibodies: technologies toward next-generation antibody-drug conjugates, ChemBioChem, 20, 2729, 10.1002/cbic.201900178 Zhou, 2017, Site-specific antibody conjugation for ADC and beyond, Biomedicines, 5, 10.3390/biomedicines5040064 Vosjan, 2010, Conjugation and radiolabeling of monoclonal antibodies with zirconium-89 for PET imaging using the bifunctional chelate p-isothiocyanatobenzyl-desferrioxamine, Nat Protoc, 5, 739, 10.1038/nprot.2010.13 Zeglis, 2011, A practical guide to the construction of radiometallated bioconjugates for positron emission tomography, Dalton Trans, 40, 6168, 10.1039/c0dt01595d Wakankar, 2011, Analytical methods for physicochemical characterization of antibody drug conjugates, mAbs, 3, 161, 10.4161/mabs.3.2.14960 Verel, 2003, 89Zr immuno-PET: comprehensive procedures for the production of 89Zr-labeled monoclonal antibodies, J. Nucl. Med., 44, 1271 Poot, 2019, Fully automated 89Zr labeling and purification of antibodies, J Nucl Med, 60, 691, 10.2967/jnumed.118.217158 Rossin, 2010, In vivo chemistry for pretargeted tumor imaging in live mice, Angew Chem Int Ed, 49, 3375, 10.1002/anie.200906294 Singh, 2018, Monoclonal antibodies: a review, Curr Clin Pharmacol, 13, 85, 10.2174/1574884712666170809124728 Wooten, 2012, An automated system for production of 89Zr, 201, 10.1063/1.4773968 Holland, 2009, Standardized methods for the production of high specific-activity zirconium-89, Nucl Med Biol, 36, 729, 10.1016/j.nucmedbio.2009.05.007 Meares, 1984, Conjugation of antibodies with bifunctional chelating agents: isothiocyanate and bromoacetamide reagents, methods of analysis, and subsequent addition of metal ions, Anal Biochem, 142, 68, 10.1016/0003-2697(84)90517-7 Chen, 2019, Denoising scheme based on singular-value decomposition for one-dimensional spectra and its application in precision storage-ring mass spectrometry, Phys Rev E, 99, 10.1103/PhysRevE.99.063320 Yu, 2010, Quantification and deconvolution of asymmetric LC-MS peaks using the bi-Gaussian mixture model and statistical model selection, BMC Bioinformatics, 11, 10.1186/1471-2105-11-559 Wagh, 2018, Challenges and new frontiers in analytical characterization of antibody-drug conjugates, mAbs, 10, 222, 10.1080/19420862.2017.1412025 Abedi, 2019, MALDI-MS: a rapid and reliable method for drug-to-antibody ratio determination of antibody-drug conjugates, Iran Biomed J, 23, 395, 10.29252/ibj.23.6.395 Siegel, 1997, Calicheamicin derivatives conjugated to monoclonal antibodies: determination of loading values and distributions by infrared and UV matrix-assisted laser Desorption/Ionization mass spectrometry and electrospray ionization mass spectrometry, Anal Chem, 69, 2716, 10.1021/ac970035q Knall, 2013, Inverse electron demand diels-Alder (iEDDA)-initiated conjugation: a (high) potential click chemistry scheme, Chem Soc Rev, 42, 5131, 10.1039/c3cs60049a Lim, 2014, Succinimidyl ester surface chemistry: implications of the competition between aminolysis and hydrolysis on covalent protein immobilization, Langmuir, 30, 12868, 10.1021/la503439g