Nội dung được dịch bởi AI, chỉ mang tính chất tham khảo
So sánh khả năng sinh tồn của bệnh nhân ung thư gan tế bào (HCC) giai đoạn A theo phân loại Barcelona sau phẫu thuật cắt gan hoặc liệu pháp hóa chất động mạch: Phân tích dựa trên điểm số xu hướng
Tóm tắt
Hiện chưa rõ phẫu thuật cắt gan (HR) hay liệu pháp hóa chất động mạch (TACE) có liên quan đến kết quả điều trị tốt hơn cho bệnh nhân ung thư gan tế bào (HCC) ở giai đoạn A theo phân loại Barcelona Clinic Liver Cancer (BCLC). Nghiên cứu hiện tại so sánh khả năng sống sót của bệnh nhân HCC giai đoạn A được điều trị bằng HR hoặc TACE. Nghiên cứu của chúng tôi đã xem xét 360 bệnh nhân điều trị bằng HR và 221 bệnh nhân điều trị bằng TACE. Để giảm thiểu thiên lệch trong việc chọn bệnh nhân, chúng tôi tạo ra 152 cặp bệnh nhân điều chỉnh theo điểm số xu hướng, và so sánh khả năng sống lâu dài của họ bằng phương pháp Kaplan–Meier. Các yếu tố tiên lượng độc lập về khả năng sống sót đã được xác định bằng mô hình nguy cơ tỷ lệ Cox. Trong số các cặp bệnh nhân được điều chỉnh theo điểm số xu hướng với chức năng gan Child-Pugh A được điều trị bằng HR hoặc TACE, tỷ lệ sống toàn bộ 1 năm, 3 năm và 5 năm lần lượt là 75,5%, 44,8% và 30,2% sau HR và 64,5%, 24,1% và 13,7% sau TACE (P < 0,001). Mức AST huyết thanh, mức AFP huyết thanh, kích thước khối u và TACE đều tiên đoán độc lập khả năng sống sót trong phân tích hồi quy Cox. Nghiên cứu điều chỉnh theo điểm số xu hướng của chúng tôi xác nhận rằng HR có liên quan đến tỷ lệ sống sót cao hơn so với TACE ở bệnh nhân HCC giai đoạn A theo phân loại BCLC.
Từ khóa
#Ung thư gan tế bào #Giai đoạn A #Phẫu thuật cắt gan #Liệu pháp hóa chất động mạch #Khả năng sống sót #Mô hình nguy cơ tỷ lệ CoxTài liệu tham khảo
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