Comparison of Surgically Repaired Achilles Tendon Tears Using Platelet-Rich Fibrin Matrices

American Journal of Sports Medicine - Tập 35 Số 2 - Trang 245-251 - 2007
Mikel Sánchez1, Eduardo Anitua2, Juan Azofra1, Isabel Andı́a2, Sabino Padilla3, Iñigo Mujika3
1Arthroscopic Surgery Unit, USP–La Esperanza Clinic, Vitoria-Gasteiz, Basque Country, Spain
2BTI Biotechnology Institute, Vitoria-Gasteiz, Basque Country, Spain
3Department of Research and Development, Medical Services, Athletic Club Bilbao, Basque Country, Spain

Tóm tắt

Background Platelet-rich fibrin matrices release a natural mixture of growth factors that play central roles in the complex processes of tendon healing. Hypothesis Application of autologous platelet-rich matrices during Achilles tendon surgery may promote healing and functional recovery. Study Design Case-control study and descriptive laboratory study; Level of evidence, 3. Methods Twelve athletes underwent open suture repair after complete Achilles tendon tear. Open suture repair in conjunction with a preparation rich in growth factors (PRGF) was performed in 6 athletes and retrospectively compared with a matched group that followed conventional surgical procedure. The outcomes were evaluated on the basis of range of motion, functional recovery, and complications. Achilles tendons were examined by ultrasound at 50 ± 11 months in retrospective controls and 32 ± 10 months in the PRGF group. In the laboratory portion of the study, PRGF treatment was characterized by the number of platelets and concentration of insulin (IGF-I), transformed (TGF-β1), platelet-derived (PDGF-AB), vascular endothelial (VEGF), hepatocyte (HGF), and epidermal (EGF) growth factors in patients affected by musculoskeletal traumatic injuries. Results Athletes receiving PRGF recovered their range of motion earlier (7 ± 2 weeks vs 11 ± 3 weeks, P = .025), showed no wound complication, and took less time to take up gentle running (11 ± 1 weeks vs 18 ± 3 weeks, P = .042) and to resume training activities (14 ± 0.8 weeks vs 21 ± 3 weeks, P = .004). The cross-sectional area of the PRGF-treated tendons increased less (t = 3.44, P = .009). TGF-β1 (74.99 ± 32.84 ng/mL), PDGF-AB (35.62 ± 14.57 ng/mL), VEGF (383.9 ± 374.9 pg/mL), EGF (481.5 ± 187.5 pg/mL), and HGF (593.87 ± 155.76 pg/mL) significantly correlated with the number of platelets (677 ± 217 platelets/μL, P < .05). Conclusion The operative management of tendons combined with the application of autologous PRGF may present new possibilities for enhanced healing and functional recovery. This needs to be evaluated in a randomized clinical trial.

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American Journal of Sports Medicine

Tập 35 Số 2

245-251

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