So sánh sự biểu hiện PD-L1 trong ung thư biểu mô tế bào vảy nguyên phát không xác định và ung thư biểu mô tế bào vảy vùng hầu họng

Benedikt Schmidl1, Kim-Aylin Voßenkämper1, Leonhard Stark1, Melanie Boxberg2, Fabian Stögbauer2, Katharina Feigl1, Christof Winter3, Anja Pickhard1, Barbara Wollenberg1, Markus Wirth1
1Department of Otolaryngology Head and Neck Surgery, Technical University Munich, Munich, Germany
2Institute of Pathology, Technical University Munich, Munich, Germany
3Institute of Clinical Chemistry and Pathobiochemistry, Technical University Munich, Munich, Germany

Tóm tắt

Tóm tắt Mục đích

Sự hình thành khối u của ung thư biểu mô tế bào vảy nguyên phát không xác định (SCCUP) ở vùng đầu và cổ vẫn chưa được làm sáng tỏ, trong khi tỷ lệ sống sót thấp và các lựa chọn điều trị hạn chế tạo ra một thách thức nghiêm trọng. Mục tiêu của dự án này là điều tra các đặc điểm miễn dịch của SCCUP và so sánh chúng với ung thư biểu mô tế bào vảy vùng hầu họng (OPSCC).

Phương pháp

Sự biểu hiện PD-L1 (TC) đã được kiểm tra bằng phương pháp nhuộm miễn dịch trong 50 di căn hạch bạch huyết của SCCUP và 47 mẫu nguyên phát của OPSCC. Sự xâm nhập của tế bào lympho CD3 + và CD8 + được đo đếm trong 5 trường hợp có độ phóng đại cao. Sự biểu hiện của p16 và HPV ISH cũng được đánh giá.

Kết quả

SCCUP cho thấy sự biểu hiện PD-L1 cao hơn một cách đáng kể so với OPSCC. Trong các SCCUP âm tính với p16, PD-L1 chứng tỏ là một yếu tố tiên lượng độc lập để ưu tiên các bệnh nhân có nguy cơ cao.

Kết luận

Các khác biệt miễn dịch giữa SCCUP và OPSCC đã được phát hiện. Sự biểu hiện PD-L1 cao hơn ở SCCUP có thể tạo điều kiện thuận lợi cho việc đánh giá thêm liệu pháp ức chế điểm kiểm soát.

Từ khóa


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