Comparative study on brain pharmacokinetics of Buyang Huanwu Decoction in normal and cerebral ischemia rats using brain microdialysis combined with LC-MS/MS

Chen, 2019, Research progress on the pathogenesis and common treatment of ischemic stroke, China Journal of Chinese Materia Medica, 44, 422 Fu, 2014, Calycosin-7-O-β-D-glucoside regulates nitric oxide /caveolin-1/matrix metalloproteinases pathway and protects blood-brain barrier integrity in experimental cerebral ischemia-reperfusion injury, Journal of Ethnopharmacology, 155, 692, 10.1016/j.jep.2014.06.015 Gong, 2019, Protective effect and mechanism of sodium ferulate on cerebral ischemia-reperfusion inflammatory injury in rats, Chinese Journal of Experimental Traditional Medical Formulae, 25, 94 Gubern-Mérida, 2022, Cav-1 Protein levels in serum and infarcted brain correlate with hemorrhagic volume in a mouse model of thromboembolic stroke, independently of rt-PA administration, Molecular Neurobiology, 59, 1320, 10.1007/s12035-021-02644-y Lin, 2016, Protective effect of ligustrazolide A on cerebral ischemia-reperfusion injury in rats, Journal of North Pharmacy, 13, 114 Lin, 2021, Investigation on the weakness of elderly patients with sequelae of ischemic stroke and analysis of its risk factors, Chinese Journal of Geriatric Heart Brain and Vessel Diseases, 23, 499 Liu, 2020, Research progress of gastrointestinal dysfunction after stroke, Guangxi Medicine Journal, 42, 2575 Longa, 1989, Reversible middle cerebral artery occlusion without craniectomy in rats, Stroke, 20, 84, 10.1161/01.STR.20.1.84 Shen, 2019, Study on pharmacokinetics of Buyanghuanwu Decoction with different doses of Astragalus membranaceus combined with microdialysis technology and liquid mass combination in rats with cerebral ischemia injury, Chinese Journal of Hospital Pharmacy, 39, 996 Tao, 2018, Preclinical research progress of prolonged thrombolysis time window in the treatment of tPA in ischemic stroke, Chinese Journal of Comparative Medicine, 28, 118 Wang, 2020, The pharmacokinetics study of Buyang Huanwu Decoction with different doses of Astragalus membranaceus by microdialysis combined with LC-MS in rats with cerebral ischemia injury, Journal of Chinese Pharmaceutical Sciences, 29, 90, 10.5246/jcps.2020.02.007 Wu, 2020, 38 Wu, 2020, Protective effect of paeoniflorin on acute cerebral infarction in rats, Current Pharmaceutical Biotechnology, 21, 702, 10.2174/1389201021666191224151634 Xiao, 2010, Neuroprotection and enhanced neurogenesis by tetramethylpyrazine in adult rat brain after focal ischemia, Neurological Research, 32, 547, 10.1179/174313209X414533 Xu, 2017, Chemical comparison of two drying methods of mountain cultivated Ginseng by UPLC-QTOF-MS/MS and multivariate statistical analysis, Molecules (Basel, Switzerland), 22, 717, 10.3390/molecules22050717 Ye, 2019, Sensory qualities, aroma components, and bioactive compounds of Anoectochilus roxburghii (Wall.) lindl. as affected by different drying methods, Industrial Crops and Products, 134, 80, 10.1016/j.indcrop.2019.03.063 Yu, 2021, Therapeutic targets and molecular mechanism of calycosin for the treatment of cerebral ischemia/reperfusion injury, Aging, 13, 16804, 10.18632/aging.203219 Zhang, 2020, Discussion on metabolomics research strategy based on microdialysis technology, China Journal of Chinese Materia Medica, 45, 214