Comparative pharmacology of calcium antagonists: Nifedipine, verapamil and diltiazem

American Journal of Cardiology - Tập 46 Số 6 - Trang 1047-1058 - 1980
Philip D. Henry1
1From the Cardiovascular Division, Department of Medicine, Washington University, St. Louis, Missouri USA

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Lindner, 1960, Phenyl-propyl-diphenyl-propyl-amin, eine neue Substanz mit coronargefäβerweiternder Wirkung, Arzneim Forsch, 10, 569

Haas, 1962, α-Isopropyl-α-(N-methylhomoveratryl)-γ-aminopropyl)3,4-dimethoxy-phenylacetonitrol, eine Substanz mit coronargefäβerweiternden Eigenschaften, Arzneim Forsch, 12, 549

Melville, 1965, Coronary vasodilatory and cardiac adrenergic blocking effects of iproveratril, Can J Physiol Pharmacol, 43, 339, 10.1139/y65-033

Haas, 1967, Vergleichende Untersuchungen der Wirkung von α-lsopropyl-α-(methyl-N-homoveratryl)-γ-aminopropyl)- 3,4-dimethoxy-phenylacetonitril, seiner Derivate sowie einiger anderer Coronardilatatoren und β-Receptor-affiner Substanzen, Arzneim Forsch, 17, 257

Fleckenstein, 1967, Zum Wirkungs-mechanismus neuartiger Koronardilatatoren mit gleichzeitig Sauerstoff-einsparenden Myokard-Effekten, Prenylamin und Iproveratril, Z Kreislaufforsch, 56, 716

Fleckenstein, 1967, Zum Wirkungs-mechanismus neuartiger Koronardilatatoren mit gleichzeitig Sauerstoff-einsparenden Myokard-Effekten, Prenylamin und Iproveratril, Z Kreislaufforsch, 56, 839

Fleckenstein, 1970, Die Zügelung des Myocardstoffwechsels durch Verapamil: Angriffspunkte und Anwendungsmöglichkeiten, Arzneim Forsch, 20, 1317

Grun, 1972, Die elektromechanische Entkoppelung der glatten Gefässmuskulatur als Grundprinzip der Coronardiltation durch 4-(2′-Nitrophenyl)-2, 6-dimethyl-1,4-dihydropyridine-3,5-dicarbonsäure -dimethylester (Bay a 1040, Nifedipine), Arzneim Forsch (Drug Res), 22, 334

Weder, 1973, Ca++-antagonistische elektromechanisch Entkoppelung der glatten Gefäβmuskulatur als Wirkungsprinzip vasodilatatorischer Nitroverbindungen, Naunyn Schmiedebergs Arch Pharmacol, 277, R88

Fleckenstein, 1977, Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle, Annu Rev Pharmacol Toxicol, 17, 149, 10.1146/annurev.pa.17.040177.001053

Henry, 1979, Calcium antagonists: mechanism of action with special reference to nifedipine, 227

Henry, 1979, Calcium ion (Ca++) antagonists: mechanisms of action and clinical applications, Practical Cardiol, 5, 145

Reinhardt, 1977, Effects of D 600 and papaverine on the inotropic response to isoprenaline on left guinea-pig atria under the graded influence of changes of frequency and temperature, Arch Int Pharmacodyn Ther, 229, 67

Bristow, 1977, Effect of diazoxide, verapamil and compound D600 on isoproterenol and calcium-mediated doseresponse relationships in isolated rabbit atrium, Eur J Pharmacol, 45, 267, 10.1016/0014-2999(77)90009-7

Kaufmann, 1977, Differenzierung verschiedener Kalzium-Antagonisten, Münch Med Wochenschr, 199, 6

Van Nuehn, 1980, Improvement of tissue perfusion with inhibitors of calcium ion influx, Biochem Pharmacol, 29, 479, 10.1016/0006-2952(80)90365-2

Van Breemen, 1973, Factors controlling cytoplasmic Ca2+ concentration, Philos Trans R Soc Lond [Biol], 265, 57, 10.1098/rstb.1973.0009

Fleckenstein, 1979, Vergleichende Untersuchungen über die Ca++-antagonistischen Grundwirkungen von Niludipin (Bay a 7168) und Nifedipin (Bay a 1040) auf Myokard, Myometrium und glatte Gefäβmuskulatur, Arzneim Forsch, 29, 230

Thorens, 1979, Effects of some vasodilators on calcium translocation in intact and fractionated vascular smooth muscle, Eur J Pharmacol, 54, 79, 10.1016/0014-2999(79)90410-2

Vater, 1972, Zur Pharmakologie von 4-(2′Nitro-phenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsäuredimethylester (Nifedipin, Bay a 1040), Arzneim Forsch, 22, 1

Sato, 1971, Pharmacological studies on a new 1,5-benzothiazepine derivative (CRD 401 = Diltiazem), Arzneim Forsch, 21, 1338

Kokuchi, 1970, Hypotensive action of N-ethoxy-carbonyl-3-morpholinosydnonimine: SIN-10, Jpn J Pharmacol, 20, 102, 10.1254/jjp.20.102

Rahwan, 1977, Pharmacological evaluation of new calcium antagonists: 2-substituted 3-dimethylamine-5,6-methlene-diozyindenes, J Pharmacol Exp Ther, 201, 126

Rahwan, 1979, The role of calcium antagonism in the therapeutic action of drugs, Can J Physiol Pharmacol, 57, 443, 10.1139/y79-069

Coraboeuf, 1978, Ionic basis of electrical activity in cardiac tissues, Am J Physiol, 234, H101

Hille, 1978, Ionic channels in excitable membranes: current problems and biophysical approaches, Biophys J, 22, 283, 10.1016/S0006-3495(78)85489-7

Almers, 1978, Gating currents and charge movements in excitable membranes, Rev Physiol Biochem Pharmacol, 82, 96, 10.1007/BFb0030498

Isenberg, 1977, Cardiac Purkinje fibres: [Ca2+]1 controls steady state potassium conductance, Pfluegers Arch, 371, 71, 10.1007/BF00580774

Hagiwara, 1965, Tetrodotoxin and manganese ion: effects on action potential of the frog heart, Science, 149, 1254, 10.1126/science.149.3689.1254

Gliklich, 1978, Sites of action and active forms of lidocaine and some derivatives on cardiac Purkinje Fibers, Circ Res, 43, 638, 10.1161/01.RES.43.4.638

Rougier, 1969, Existence and role of a slow inward current during the frog atrial action potential, Pfluegers Arch, 308, 91, 10.1007/BF00587018

Reuter, 1974, Exchange of calcium ions in the mammalian myocardium: mechanisms and physiological significance, Circ Res, 34, 599, 10.1161/01.RES.34.5.599

Bers, 1979, Uncoupling cation effects on cardiac contractility and sarcolemmal Ca2+ binding, Am J Physiol, 237, H332

Bayer, 1978, Comparative studies on calcium antagonists, 31

Bayer, 1977, The effects of nifedipine on contraction and monophasic action potential of isolated cat myocardium, Naunn Schmiedebergs Arch Pharmacol, 301, 29, 10.1007/BF00501261

Ehara, 1980, Effects of nifedipine on the slow inward current in isolated cat ventricular myocardium, Pfluegers Arch

Kohlhardl, 1977, Inhibition of the slow inward current by nifedipine in mammalian ventricular myocardium, Naunyn Schmiedebergs Arch Pharmacol, 298, 267, 10.1007/BF00500899

Bayer, 1975, Inotropic and electrophysiological actions of verapamil and D 600 in mammalian myocardium. III. Effects of the optical isomers on transmembrane action potentials, Naunyn Schmiedebergs Arch Pharmacol, 290, 81, 10.1007/BF00499991

Ehara, 1978, The voltage-and time-dependent effects of (−)-verapamil on the slow inward current in isolated cat ventricular myocardium, J Pharmacol Exp Ther, 207, 49

Raschack, 1976, Relationship of antiarrhythmic to inotropic activity and antiarrhythmic qualities of the optical isomers of verapamil, Naunyn Schmiedebergs Arch Pharmacol, 294, 285, 10.1007/BF00508397

Kaumann, 1976, Reversible inhibition of potassium contractures by optical isomers of verapamil and D 600 on slow muscle fibres of the frog, Naunyn Schmiedebergs Arch Pharmacol, 292, 21, 10.1007/BF00506485

Nawrath, 1977, On the mechanism underlying the action of D-600 on slow inward current and tension in mammalian myocardium, Circ Res, 40, 408, 10.1161/01.RES.40.4.408

Kohlhardt, 1972, Differentiation of the transmembrane Na and Ca channels in mammalian cardiac fibres by the use of specific inhibitors, Pfluegers Arch, 335, 309, 10.1007/BF00586221

Kass, 1975, Multiple effects of calcium antagonists on plateau currents in cardiac Purkinje fibers, J Gen Physiol, 66, 169, 10.1085/jgp.66.2.169

Kohlhardt, 1975, Kinetics of inactivation and recovery of the slow inward current in the mammalian ventricular myocardium, Pfluegers Arch, 355, 1, 10.1007/BF00584795

Saikawa, 1977, Electrophysiologic effects of diltiazem, a new slow channel inhibitor, on canine cardiac fibers, Jpn Heart J, 18, 235, 10.1536/ihj.18.235

Nabata, 1977, Effects of calcium-antagonistic coronary vasodilators on myocardial contractility and membrane potentials, Jpn J Pharmacol, 27, 239, 10.1254/jjp.27.239

Nakajima, 1975, Effect of diltiazem on electrical and mechanical activity of isolated cardiac ventricular muscle of guinea pig, Jpn J Pharmacol, 25, 383, 10.1254/jjp.25.383

Harder, 1979, Differential effects of adenosine and nitroglycerin on the action potentials of large and small coronary arteries, Circ Res, 44, 176, 10.1161/01.RES.44.2.176

Takeda, 1977, Effects of coronary vasodilators on large and small coronary arteries of dogs, Jpn Heart J, 18, 92, 10.1536/ihj.18.92

Massingham, 1973, A study of compounds which inhibit vascular smooth muscle contraction, Eur J Pharmacol, 22, 75, 10.1016/0014-2999(73)90186-6

Nguyen Duong, 1977, Untersuchungen über Mechanismen der Kontraktionsauslösung am glatten Gefäβmuskel und ihre Beeinflussung durch Kalzium-Antagonisten, Münch Med Wochenschr, 119, S12

Fermum, 1977, Versuche zum Wirkungsmechanismus von Gefäβspasmolytika: Wirkung von Nitroprussid-Natrium, Nitroglyzerin, Prenylamin und Verapamil an der Fluorid-induzierten Kontraktur isolierter Koronararterien, Acta Biol Med Ger, 36, 245

Mikkelsen, 1979, Verapamil and nifedipine inhibition of contractions induced by potassium and noradrenaline in human mesenteric arteries and veins, Acta Pharmacol Toxicol (Copenh), 44, 110, 10.1111/j.1600-0773.1979.tb02304.x

Rodenkirchen, 1979, Structure-activity studies on nifedipine in isolated cardiac muscle, Naunyn Schmiedebergs Arch Pharmacol, 310, 69, 10.1007/BF00499876

Mannhold, 1978, Investigations on the structure-activity relationships of verapamil, Naunyn Schmiedebergs Arch Pharmacol, 302, 217, 10.1007/BF00517988

Jakobsen, 1979, Gas Chromatographic determination of nifedipine and one of its metabolites using electron capture detection, J Chromatogr, 162, 81, 10.1016/S0378-4347(00)82066-6

Schlossmann, 1975, Investigations on the metabolism and protein binding of nifedipine, 33

Schomerus, 1976, Physiological disposition of verapamil in man, Cardiovasc Res, 10, 605, 10.1093/cvr/10.5.605

Eichelbaum, 1979, The metabolism of DL-[14C]verapamil in man, Drug Metab Dispos, 7, 145

Koike, 1979, Pharmacokinetics of verapamil in man, Res Commun Chem Pathol Pharmacol, 24, 37

Mangiardi, 1978, Electrophysiologic and hemodynamic effects of verapamil: correlation with plasma drug concentrations, Circulation, 57, 366, 10.1161/01.CIR.57.2.366

Kohno, 1977, Pharmacokinetics and bioavailability of diltiazem (CRD-401) in dog, Arnzeim Forsch, 27, 1424

Lichtlen, 1976, Mechanisms of various antianginal drugs. Relationship between regional flow behavior and contractility, 14

Beck, 1978, Wirkung und Wirkungsdauer von Nifedipine auf den Pulmonalarteriendruck bei dekompensierten Koronarkranken, Med Klin, 73, 457

Vincenzi, 1976, Hemodynamic effects caused by i.v. administration of verapamil in healthy subjects, Arzneim Forsch, 26, 1221

Kinoshita, 1979, Comparison of hemodynamic effects between β-blocking agents and a new antianginal agent, diltiazem hydrochloride, Jpn Circ J, 43, 587, 10.1253/jcj.43.587

Refsum, 1975, The effect of a calcium-antagonistic drug, nifedipine, on the mechanical and electrical activity of the isolated rat atrium, Acta Pharmacol Toxicol, 37, 369, 10.1111/j.1600-0773.1975.tb00855.x

Baumann, 1976, On the action of nifedipine under conditions of variable stimulation patterns and [Ca2+]0 in guinea-pig atrium, Naunyn Schmiedebergs Arch Pharmacol, 294, 161, 10.1007/BF00507849

Haeusler, 1971, The effect of verapamil on the contractility of smooth muscle and on excitation-secretion coupling in adrenergic nerve terminals, 8, 156

Starke, 1973, Wirkung von Nifedipine auf die Funktion der sympathischen Nerven des Herzens, Arzneim Forsch, 23, 193

Gross, 1979, Effects of nifedipine on coronary and systemic hemodynamics in the conscious dog, Arzneim Forsch, 29, 1361

Koroku, 1975, Nifedipine, basis of its pharmacological effect, 11

Lydtin, 1975, Hemodynamic studies on Adalat in healthy volunteers and in patients, 112

Lichtlen, 1980, The effect of the calcium antagonistic drug nifedipine on coronary and left ventricular dynamics in patients with coronary heart disease, 270

Raschack, 1976, Differences in the cardiac actions of the calcium antagonists verapamil and nifedipine, Arzneim Forsch, 26, 1330

Narimatsu, 1976, Effects on atrio-ventricular conduction of calcium-antagonistic coronary vasodilators, local anaesthetics and quinidine injected into the posterior and the anterior septal artery of the atrio-ventricular node preparation of the dog, Naunyn Schmiedebergs Arch Pharmacol, 294, 169, 10.1007/BF00507850

Rowland, 1979, Effect of nifedipine on atrioventricular conduction as compared with verapamil: intracardiac electrophysiological study, Br Heart J, 42, 124, 10.1136/hrt.42.2.124

Ebner, 1977, Wirkung und Verträglichkeit von Adalat0 bei Kombination mit verschiedenen Medikamenten, Münch Med Wochenschr, 199, 69

Gutovitz, 1977, Resistance of ventricular dysrhythmia to nifedipine, a calcium antagonist (abstr), Circulation, 56, III

Ferlinz, 1979, Effects of verapamil on myocardial performance in coronary disease, Circulation, 59, 313, 10.1161/01.CIR.59.2.313

Kusukawa, 1977, Haemodynamic effects of a new anti-anginal drug, diltiazem hydrochloride, Arzneim Forsch, 27, 878

Henry, 1979, Chronotropic and inotropic effects of vasodilators, 14

Scherf, 1974, “Variant” angina pectoris, Circulation, 49, 787, 10.1161/01.CIR.49.5.787

Endo, 1975, Prinzmetal's variant form of angina pectoris: re-evaluation of mechanisms, Circulation, 52, 33, 10.1161/01.CIR.52.1.33

Yasue, 1978, Pathogenesis and treatment of angina pectoris at rest as seen from its response to various drugs, Jpn Circ J, 42, 1, 10.1253/jcj.42.1

Kimura, 1978, Panel discussion on the variant form of angina pectoris, Jpn Cire J, 42, 455, 10.1253/jcj.42.455

Kishida, 1980, Application of calcium antagonists in patients with Prinzmetal angina pectoris, 246

Yasue, 1979, Exertional angina pectoris caused by coronary arterial spasm: effects of various drugs, Am J Cardiol, 43, 647, 10.1016/0002-9149(79)90026-2

Yasue, 1979, Circadian variation of exercise capacity in patients with Prinzmetal's variant angina: role of exercise-induced coronary arterial spasm, Circulation, 59, 938, 10.1161/01.CIR.59.5.938

Yasue, 1978, Coronary arterial spasm and Prinzmetal's variant form of angina induced by hyperventilation and Tris-buffer infusion, Circulation, 58, 56, 10.1161/01.CIR.58.1.56

Kimura, 1977, Suppression of repeatedly occurring ventricular fibrillation with nifedipine in variant form of angina pectoris, Jpn Heart J, 18, 736, 10.1536/ihj.18.736

Campbell, 1979, Nifedipine in the treatment of life threatening Prinzmetal angina, Aust NZ J Med, 9, 293, 10.1111/j.1445-5994.1979.tb04141.x

Ebner, 1976, Haemodynamics, therapeutic mechanism of action and clinical findings of Adalat use based on worldwide clinical trials, 283

Wellens, 1977, Effect of verapamil studied by programmed electrical stimulation of the heart in patients with paroxysmal re-entrant supraventricular tachycardia, Br Heart J, 39, 1058, 10.1136/hrt.39.10.1058

Schlepper, 1978, Haemodynamic effects of supraventricular tachycardias and their alterations by electrically and verapamil induced termination, Cardiovasc Res, 12, 28, 10.1093/cvr/12.1.28

Singh, 1978, Verapamil: a review of it pharmacological properties and therapeutic use, Drugs, 15, 169, 10.2165/00003495-197815030-00001

Elharrar, 1977, Effect of drugs on conduction delay and incidence of ventricular arrhythmias induced by acute coronary occlusion in dogs, Am J Cardiol, 39, 544, 10.1016/S0002-9149(77)80164-1

Fondacaro, 1978, Effects of verapamil on ventricular rhythm during acute coronary occlusion, Am Heart J, 96, 81, 10.1016/0002-8703(78)90129-1

El-Sherif, 1979, Reentrant ventricular arrhythmias in the late myocardial infarction period 7. Effect of verapamil and D-600 and the role of the “slow channel.”, Circulation, 60, 605, 10.1161/01.CIR.60.3.605

Kuwajima, 1978, A study on the effects of nifedipine in hypertensive crises and severe hypertension, Jpn Heart J, 19, 455, 10.1536/ihj.19.455

Guazzl, 1977, Nifedipine, a new antihypertensive with rapid action, Clin Pharmacol Ther, 22, 528, 10.1002/cpt1977225part1528

Laaser, 1977, Zur klinischen Bewertung der Kombinationsbehandlung von Nifedipin mit verschiedenen Antihypertensiva, Arzneim Forsch, 27, 676

Pedersen, 1978, Does verapamil have a clinically significant antihypertensive effect?, Eur J Pharmacol, 13, 21, 10.1007/BF00606677

Henry, 1978, Effects of nifedipine on myocardial perfusion and ischemic injury in dogs, Circ Res, 43, 372, 10.1161/01.RES.43.3.372

Henry, 1979, Effect of nifedipine on myocardial ischemia; analysis of collateral flow, pulsatile heat and regional muscle shortening, Am J Cardiol, 44, 817, 10.1016/0002-9149(79)90203-0

Smith, 1976, Regional contractility: selective depression of ischmic myocardium by verapamil, Circ Res, 54, 629, 10.1161/01.CIR.54.4.629

Reimer, 1977, Effects of the calcium antagonist verapamil on necrosis following temporary coronary artery occlusion in dogs, Circulation, 55, 581, 10.1161/01.CIR.55.4.581

Henry, 1977, Myocardial contracture and accumulation of mitochondrial calcium in ischemic rabbit heart, Am J Physiol, 233, H677

Nayler, 1978, The effect of /gb-adrenoceptor and Ca2+ antagonist drugs on the hypoxia-induced increase in resting tension, Cardiovasc Res, 12, 666, 10.1093/cvr/12.11.666

Clark, 1977, Pharmacological preservation of the ischemic heart, Ann Thorac Surg, 24, 307, 10.1016/S0003-4975(10)63405-4

Jasmin, 1979, Therapeutic trials in hamster dystrophy, Ann NY Acad Sci, 317, 338, 10.1111/j.1749-6632.1979.tb56544.x

Kaltenbach, 1976, Calciumantagonistische Therapie bei hypertroph-obstruktiver Kardiomyopathie, Dtsch Med Wochenschr, 101, 1284, 10.1055/s-0028-1104257

Rosing, 1979, Verapamil therapy: treatment of hypertrophic cardiomyopathy, Circulation, 60, 1201, 10.1161/01.CIR.60.6.1201