Comparative metabolomics analysis for the compatibility and incompatibility of kansui and licorice with different ratios by UHPLC-QTOF/MS and multivariate data analysis

Committee for the Pharmacopoeia of PR China, 2015 Shen, 2016, The chemical and biological properties of Euphorbia kansui, Am. J. Chin. Med., 44, 253, 10.1142/S0192415X16500154 Guo, 2014, Data mining and frequency analysis for licorice as a Two-Face herb in Chinese formulae based on Chinese Formulae Database, Phytomedicine, 21, 1281, 10.1016/j.phymed.2014.07.006 Duan, 2012, Research thoughts and technology system framework of traditional Chinese medicine incompatibility, World Sci. Technol./Mod. Tradit. Chin. Med. Mater. Med., 14, 1537 Huang, 2004, Effect of licorice and kansui combination on the functions and pathological histomorphology of heart, liver and kidney in rat, Chin. J. Clin. Rehab., 8, 5996 Shen, 2016, Dosage-toxicity-efficicacy relationship of Kansui Radix in maglignant pleural effusion models based on Walker 256 analysis, China J. Chin. Mater. Med., 41, 1713 Shen, 2016, The dosage-toxicity-efficacy relationship of kansui and licorice in malignant pleural effusion rats based on factor analysis, J. Ethnopharmacol., 186, 251, 10.1016/j.jep.2016.04.012 Chen, 2016, Metabolomic application in toxicity evaluation and toxicological biomarker identification of natural produce, Chem-Biol. Interact., 252, 114, 10.1016/j.cbi.2016.03.028 Lin, 2016, Urinary metabonomic study of Panax ginseng in deficiency of vital energy rat using ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry, J. Ethnopharmacol., 184, 10, 10.1016/j.jep.2016.02.031 Jiang, 2012, Syndrome differentiation in modern research of traditional Chinese medicine, J. Ethnopharmacol., 140, 634, 10.1016/j.jep.2012.01.033 Zhang, 2016, Metabonomic study on the plasma of streptozotocin-induced diabetic rats treated with Ge Hen Qin Lian Decoction by ultra high performance liquid chromatography-mass spectrometry, J. Pharm. Biomed., 120, 175, 10.1016/j.jpba.2015.12.031 Theodoridis, 2008, LC-MS-based methodology for global metabolite profiling in metabonomics/metabonomics, Trac-Trend. Anal. Chem., 27, 251, 10.1016/j.trac.2008.01.008 Wong, 2008, An approach towards method development for untargeted urinary metabolite profiling in metabonomic research using UPLC/QTOF MS, J. Chromatogr. B, 871, 341, 10.1016/j.jchromb.2008.06.033 Shen, 2013, Analysis of herb–herb interaction when decocting together by using ultra-high-performance liquid chromatography-tandem mass spectrometry and fuzzy chemical identification strategy with poly-proportion design, J. Chromatogr. A, 1297, 168, 10.1016/j.chroma.2013.05.001 Godzien, 2010, Metabonomic approach with LC-QTOF to study the effect of a nutraceutical treatment on urine of diabetic rats, J. Proteome Res., 10, 837, 10.1021/pr100993x Li, 2014, Comparative metabonomics analysis on hematinic functions of herb pair Gui-Xiong by ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry and pattern recognition approach, J. Chromatogr. A, 1346, 49, 10.1016/j.chroma.2014.04.042 Li, 2015, Urine and plasma metabonomics coupled with UHPLC-QTOF/MS and multivariate data analysis on potential biomarkers in anemia and hematinic effects of herb pair Gui-Hong, J. Ethnopharmacol., 170, 175, 10.1016/j.jep.2015.05.019 Xia, 2012, MetaboAnalyst 2.0—a comprehensive server for metabonomic data analysis, Nucleic Acids Res., 40, 127, 10.1093/nar/gks374 Lenz, 2007, Analytical strategies in metabonomics, J. Proteome Res., 6, 443, 10.1021/pr0605217 Yu, 2009, Study on THz spectra of nicotinic acid, nicotinamide and nicotine, Spectrosc. Spectr. Anal., 29, 2334 Penberthy, 2009, Nicotinamide adenine dinucleotide biology and disease, Curr. Pharm. Des., 15, 1, 10.2174/138161209787185779 Qin, 2012, Nicotinamide phosphoribosyltransferase inhibitors in cancer therapy: an advance, Acad. J. Second Mil. Med. Univ., 33, 794 Bai, 2009, Study on superoxide anion radical scavenging activity of seleno-sulfur-containing amino acid, Acta Nutrimenta Sin., 31, 26