Comparative genomics reveal shared genomic changes in syngnathid fishes and signatures of genetic convergence with placental mammals

National Science Review - Tập 7 Số 6 - Trang 964-977 - 2020
Yanhong Zhang1, Vydianathan Ravi2, Geng Qin1,3, He Dai4, Huixian Zhang1, Fengming Han4, Xin Wang1, Yuhong Liu1, Jianping Yin1,3, Liangmin Huang1,5, Byrappa Venkatesh2, Qiang Lin1,3,5
1CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Innovation Academy of South China Sea Ecology and Environmental Engineering, Chinese Academy of Sciences, Guangzhou 510301, China
2Comparative and Medical Genomics Laboratory, Institute of Molecular and Cell Biology, A*STAR 138673, Singapore
3Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou), Guangzhou, 511458, China
4Biomarker Technologies Corporation, Beijing 101300, China
5University of Chinese Academy of Sciences, Beijing, 100049, China

Tóm tắt

Abstract

Syngnathids (seahorses, pipefishes and seadragons) exhibit an array of morphological innovations including loss of pelvic fins, a toothless tubular mouth and male pregnancy. They comprise two subfamilies: Syngnathinae and Nerophinae. Genomes of three Syngnathinae members have been analyzed previously. In this study, we have sequenced the genome of a Nerophinae member, the Manado pipefish (Microphis manadensis), which has a semi-enclosed brood pouch. Comparative genomic analysis revealed that the molecular evolutionary rate of the four syngnathids is higher than that of other teleosts. The loss of all but one P/Q-rich SCPP gene in the syngnathids suggests a role for the lost genes in dentin and enameloid formation in teleosts. Genome-wide comparison identified a set of 118 genes with parallel identical amino acid substitutions in syngnathids and placental mammals. Association of some of these genes with placental and embryonic development in mammals suggests a role for them in syngnathid pregnancy.

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