Comparative evaluation of intravenous phenytoin, procainamide and practolol in the acute treatment of ventricular arrhythmias
Tóm tắt
Ten patients with a persistent ventricular arrhythmia, but no other sign of heart disease, were studied by means of an exercise test performed 4 times with a fixed work load, over 30–40 min. No drug was given in the first exercise test and in the others phenytoin, procainamide or practolol were chosen at random for i. v. administration. Blood samples for determination of plasma concentration were frequently collected. The ECG was recorded continuously during the exercise test and was analysed minute by minute. Despite plasma levels within the suggested therapeutic range, only procainamide showed a statistically significant antiarrhythmic effect in this group of patients.
Tài liệu tham khảo
Allen, J. D., Pantridge, J. F., Shanks, R. G.: Practolol in the treatment of ventricular dysrhythmias in acute myocardial infarction. Postgrad. med. J. Suppl.47, 29–35 (1971)
Berlin, A., Agurell, S., Borgå, O., Lund, L., Sjöqvist, F.: Micromethod for the determination of diphenylhydantoin in plasma and cerebrospinal fluid — a comparison between a gas chromatographic and a spectrophotometric method. Scand. J. clin. Lab. Invest.29, 281–287 (1972)
Bigger, Jr. J. T., Schmidt, D. H., Kutt, H.: Relationship between the plasma level of diphenylhydantoin sodium and its cardiac antiarrhythmic effects. Circulation38, 363–374 (1968)
Bigger, Jr. J. T., Schmidt, D. H., Kutt, H.: A method for estimation of plasma diphenylhydantoin concentration. Amer. Heart J.77, 572–573 (1969)
Chiang, B. N., Perlman, L. V., Ostrander, Jr. L. D., Epstein, F. H.: Relationship of premature systoles to coronary heart disease and sudden death in the Tecumseh epidemiologic study. Ann. int. Med.70, 1159–1165 (1969)
Chung, E. K.: Prophylactic uses of antiarrhythmic drugs in acute myocardial infarction. Postgrad. Med.54, 197–203 (1973)
Fisher, F. D., Tyroler, H. A.: Relationship between ventricular premature contractions on routine electrocardiography and subsequent sudden death from coronary heart disease. Circulation47, 712–719 (1973)
Gey, G. O., Levy, R. H., Fisher, L., Pettet, G., Bruce, R. A.: Plasma concentration of procainamide and prevalence of exertional arrhythmias. Ann. int. Med.80, 718–722 (1974)
Giardina, E.-G. V., Heissenbuttel, R. H., Bigger, Jr. J. T.: Intermittent intravenous procaine amide to treat ventricular arrhythmias. Correlation of plasma concentration with effect on arrhythmia electrocardiogram, and blood pressure. Ann. int. Med.78, 183–193 (1973)
Hinkle, J. R., Hinkle, L. E., Carver, S. T., Stevens, M.: The frequency of asymtomatic disturbances of cardiac rhythm and conduction in middle-aged men. Amer. J. Cardiol.24, 629–650 (1969)
Hiss, R. G., Lamb, L. E.: Electrocardiographic findings in 122.043 individuals. Circulation25, 947–961 (1962)
Jewitt, D. E., Mercer, C. J., Shillingford, J. P.: Practolol in the treatment of cardiac dysrhythmias due to acute myocardial infarction. Lancet1969 II, 227–230
Karlsson, E.: Procaine amide and phenytoin. A comparative study of their antiarrhythmic effects at apparent therapeutic plasma levels. Brit. Heart J.37, 731–740 (1975)
Kistin, A. D.: Problems in differentiation of ventricular arrhythmia from supraventricular arrhythmia with abnormal QRS. Progr. cardiovasc. Dis.9, 1–17 (1966)
Koch-Weser, J., Klein, S. W., Foo-Canto, L. L., Kastor, J. A., De Sanctis, R. W.: Antiarrhythmic prophylaxis with procainamide in acute myocardial infarction. New Engl. J. Med.281, 1253–1260 (1969)
Koch-Weser, J., Klein, S. W.: Procaine amide dosage schedules, plasma concentrations and clinical effects. J. Amer. med. Ass.215, 1454–1460 (1971)
Koch-Weser, J.: Antiarrhythmic prophylaxis in ambulatory patients with coronary heart disease. Arch. inter. Med.129, 763–772 (1972)
Kosowsky, B. D., Lown, B., Whiting, R., Guiney, T.: Occurrence of ventricular arrhythmias with exercise as compared to monitoring. Circulation44, 826–832 (1971)
Mercer, E. N., Osborne, J. A.: The current status of diphenylhydantoin in heart diseases. Ann. int. Med.67, 1084–1107 (1967)
Rodstein, M., Wolloch, L., Gubner, R. S.: Mortality study of the significance of extrasystoles in an insured population. Circulation44, 617–625 (1971)
Smith, E., Bennet, D., Sowton, E.: A comparative study of dextro-alprenolol, dextro-propanolol and practolol in the treatment of ventricular ectopic beats. Guy's Hosp. Rep.120, 9–15 (1971)
Vajda, F. J. E., Prineas, R. J., Lovell, R. R. H., Sloman, J. G.: The possible effect of long-term high plasma levels of phenytoin on mortality after acute myocardial infarction. Europ. J. clin. Pharmacol.5, 138–144 (1973)