Comparação entre duas doses de ácido tranexâmico intra‐articular no sangramento pós‐operatório de artroplastia total do joelho: estudo clínico randomizado

Habermann, 1986, Total joint replacement: an overview, Semin Roentgenol., 21, 7, 10.1016/0037-198X(86)90005-2 Prasad, 2007, Blood loss in total knee arthroplasty: an analysis of risk factors, Int Orthop., 31, 39, 10.1007/s00264-006-0096-9 Ortmann, 2013, Antifibrinolytic agents in current anaesthetic practice, Br J Anaesth., 111, 549, 10.1093/bja/aet154 Tan, 2013, A meta‐analysis of the effectiveness and safety of using tranexamic acid in primary unilateral total knee arthroplasty, J Surg Res., 184, 880, 10.1016/j.jss.2013.03.099 Jang, 2014, Intra‐articular injection of tranexamic acid to reduce blood loss after total knee arthroplasty, J Orthop Surg (Hong Kong)., 22, 146, 10.1177/230949901402200205 Wang, 2017, Intra‐articular application is more effective than intravenous application of tranexamic acid in total knee arthroplasty: a prospective randomized controlled trial, J Arthroplasty., 32, 3385, 10.1016/j.arth.2017.06.024 Astedt, 1987, Clinical pharmacology of tranexamic acid, Scand J Gastroenterol Suppl., 137, 22, 10.3109/00365528709089756 Cid, 2005, Tranexamic acid reduces allogeneic red cell transfusions in patients undergoing total knee arthroplasty: results of a meta‐analysis of randomized controlled trials, Transfusion., 45, 1302, 10.1111/j.1537-2995.2005.00204.x Ipema, 2012, Use of topical tranexamic acid or aminocaproic acid to prevent bleeding after major surgical procedures, The Annals Pharmacotherapy., 46, 97, 10.1345/aph.1Q383 Nadler, 1962, Prediction of blood volume in normal human adults, Surgery., 51, 224 Mercuriali, 1996, Proposal of an algorithm to help the choice of the best transfusion strategy, Curr Med Res Opin., 13, 465, 10.1185/03007999609115227 Moskal, 2015, Transfusion cost savings with tranexamic acid in primary total knee arthroplasty from 2009 to 2012, J Arthroplasty., 30, 365, 10.1016/j.arth.2014.10.008 Sculco, 1998, Global blood management in orthopaedic surgery, Clin Orthop Relat Res., 357, 43, 10.1097/00003086-199812000-00007 Alshryda, 2014, A systematic review and meta‐analysis of the topical administration of tranexamic acid in total hip and knee replacement, Bone Joint J., 96–B, 1005, 10.1302/0301-620X.96B8.33745 Gilbody, 2014, Topical tranexamic acid reduces transfusion rates in total hip and knee arthroplasty, J Arthroplasty., 29, 681, 10.1016/j.arth.2013.09.005 Levine, 2014, Weighted versus uniform dose of tranexamic acid in patients undergoing primary, elective knee arthroplasty: a prospective randomized controlled trial, J Arthroplasty., 29, 186, 10.1016/j.arth.2014.01.038 Seo, 2013, The comparative efficacies of intra‐articular and IV tranexamic acid for reducing blood loss during total knee arthroplasty, Knee Surg Sports Traumatol Arthrosc., 21, 1869, 10.1007/s00167-012-2079-2 Shemshaki, 2015, One step closer to sparing total blood loss and transfusion rate in total knee arthroplasty: a meta‐analysis of different methods of tranexamic acid administration, Arch Orthop Trauma Surg., 135, 573, 10.1007/s00402-015-2189-7 Xie, 2019, Comparison of three routes of administration of tranexamic acid in primary unilateral total knee arthroplasty: Analysis of a national database, Thromb Res., 173, 96, 10.1016/j.thromres.2018.11.025 Li, 2017, Combined use of intravenous and topical versus intravenous tranexamic acid in primary total knee and hip arthroplasty: a meta‐analysis of randomized controlled trials, J Orthop Surg Res., 12, 22, 10.1186/s13018-017-0520-4 Li, 2018, Oral tranexamic acid reduces blood loss in total‐knee arthroplasty: A meta‐analysis, Medicine (Baltimore)., 97, e12924, 10.1097/MD.0000000000012924 Godier, 2012, Tranexamic Acid: less bleeding and less Thrombosis, Critical Care., 16, 1, 10.1186/cc11374 Benoni, 1995, Application of pharmacokinetics data from healthy volunteers for the prediction of plasma concentrations of tranexamic acid in surgical patients, Clin Drug Invest., 10, 280, 10.2165/00044011-199510050-00005 Sano, 1976, Absorption and excretion of tranexamic acid following intravenous, intramuscular and oral administrations in healthy volunteers, Jpn J Clin Pharmacol Therapeutics., 7, 375, 10.3999/jscpt.7.375 Nilsson, 1980, Clinical pharmacology of aminocaproic and tranexamic acids, J Clin Pathol Suppl (R Coll Pathol)., 14, 41, 10.1136/jcp.33.Suppl_14.41 Blanie, 2013, Duration of postoperative fibrinolysis after total hip or knee replacement: a laboratory follow‐up study, Thromb Res., 131, e6, 10.1016/j.thromres.2012.11.006