Communication protocols integrating wearables, ingestibles, and implantables for closed-loop therapies

Brown, 2019, Six-month randomized, multicenter trial of closed-loop control in type 1 diabetes, N. Engl. J. Med., 381, 1707, 10.1056/NEJMoa1907863 Hafezi, 2015, An ingestible sensor for measuring medication adherence, IEEE Trans. Biomed. Eng., 62, 99, 10.1109/TBME.2014.2341272 Li, 2020, Clinical Opportunities for Continuous Biosensing and Closed-Loop Therapies, Trends Cancer, 6, 319, 10.1016/j.trecan.2020.01.012 Bergenstal, 2010, Effectiveness of sensor-augmented insulin-pump therapy in type 1 diabetes, N. Engl. J. Med., 363, 311, 10.1056/NEJMoa1002853 Xu, 2022, Translational gaps and opportunities for medical wearables in digital health, Sci. Transl. Med., 14, eabn6036, 10.1126/scitranslmed.abn6036 Kotas, 2015, Homeostasis, inflammation, and disease susceptibility, Cell, 160, 816, 10.1016/j.cell.2015.02.010 Farmer, 2008, The future of open- and closed-loop insulin delivery systems, J. Pharm. Pharmacol., 60, 1, 10.1211/jpp.60.1.0001 Sav, 2015, Burden of treatment for chronic illness: a concept analysis and review of the literature, Health Expect., 18, 312, 10.1111/hex.12046 Gaffo, 2006, Treatment of rheumatoid arthritis, Am. J. Health Syst. Pharm., 63, 2451, 10.2146/ajhp050514 Mage, 2017, Closed-loop control of circulating drug levels in live animals, Nat. Biomed. Eng., 1, 0070, 10.1038/s41551-017-0070 Organization, 2003 Watanabe, 2018, Cost of Prescription Drug-Related Morbidity and Mortality, Ann. Pharmacother., 52, 829, 10.1177/1060028018765159 Jimmy, 2011, Patient medication adherence: measures in daily practice, Oman Med. J., 26, 155, 10.5001/omj.2011.38 Teymourian, 2020, Wearable electrochemical sensors for the monitoring and screening of drugs, ACS Sens., 5, 2679, 10.1021/acssensors.0c01318 Tan, 2022, Recent Advances in Intelligent Wearable Medical Devices Integrating Biosensing and Drug Delivery, Adv. Mater., 34, 2108491, 10.1002/adma.202108491 Wu, 2022, Microneedle aptamer-based sensors for continuous, real-time therapeutic drug monitoring, Anal. Chem., 94, 8335, 10.1021/acs.analchem.2c00829 Sunwoo, 2021, Wearable and implantable soft bioelectronics: Device designs and material strategies, Annu. Rev. Chem. Biomol. Eng., 12, 359, 10.1146/annurev-chembioeng-101420-024336 Steiger, 2018, Ingestible electronics for diagnostics and therapy, Nat. Rev. Mater., 4, 83, 10.1038/s41578-018-0070-3 Memon, 2015, 1 Abramson, 2019, An ingestible self-orienting system for oral delivery of macromolecules, Science, 363, 611, 10.1126/science.aau2277 Abramson, 2019, A luminal unfolding microneedle injector for oral delivery of macromolecules, Nat. Med., 25, 1512, 10.1038/s41591-019-0598-9 Jiang, 2023, Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing, Nat. Biotechnol., 41, 652, 10.1038/s41587-022-01528-3 Mostafalu, 2018, Smart Bandage for Monitoring and Treatment of Chronic Wounds, Small, 14, 1703509, 10.1002/smll.201703509 Wang, 2022, Wearable bioelectronics for chronic wound management, Adv. Funct. Mater., 32, 2111022, 10.1002/adfm.202111022 Choi, 2021, Fully implantable and bioresorbable cardiac pacemakers without leads or batteries, Nat. Biotechnol., 39, 1228, 10.1038/s41587-021-00948-x Piech, 2020, A wireless millimetre-scale implantable neural stimulator with ultrasonically powered bidirectional communication, Nat. Biomed. Eng., 4, 207, 10.1038/s41551-020-0518-9 Lee, 2017, Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module, Sci. Adv., 3, e1601314, 10.1126/sciadv.1601314 Kouser, 2018, pH-Responsive Biocompatible Nanocomposite Hydrogels for Therapeutic Drug Delivery, ACS Appl. Bio Mater., 1, 1810, 10.1021/acsabm.8b00260 Fuller, 2019, Externally Triggered Heat and Drug Release from Magnetically Controlled Nanocarriers, ACS Appl. Polym. Mater., 1, 211, 10.1021/acsapm.8b00100 Wang, 2022, A thrombin-triggered self-regulating anticoagulant strategy combined with anti-inflammatory capacity for blood-contacting implants, Sci. Adv., 8, eabm3378, 10.1126/sciadv.abm3378 Matsumoto, 2017, Synthetic “smart gel” provides glucose-responsive insulin delivery in diabetic mice, Sci. Adv., 3, eaaq0723, 10.1126/sciadv.aaq0723 Gu, 2013, Glucose-Responsive Microgels Integrated with Enzyme Nanocapsules for Closed-Loop Insulin Delivery, ACS Nano, 7, 6758, 10.1021/nn401617u Yu, 2020, Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs, Nat. Biomed. Eng., 4, 499, 10.1038/s41551-019-0508-y Li, 2016, Enzyme-Responsive Polymeric Vesicles for Bacterial-Strain-Selective Delivery of Antimicrobial Agents, Angew. Chem., Int. Ed. Engl., 55, 1760, 10.1002/anie.201509401 Poletto, 2016, Tailoring the internal structure of liquid crystalline nanoparticles responsive to fungal lipases: a potential platform for sustained drug release, Colloids Surf. B Biointerfaces, 147, 210, 10.1016/j.colsurfb.2016.08.003 Mi, 2010, A novel stimuli-responsive hydrogel for K+-induced controlled-release, Polymer, 51, 1648, 10.1016/j.polymer.2010.02.018 Huang, 2015, A self-regulating antimicrobial model based on the ion-exchange stimuli, J. Mater. Sci. Mater. Med., 26, 208, 10.1007/s10856-015-5546-8 Younis, 2021, Ultra-small lipid nanoparticles encapsulating sorafenib and midkine-siRNA selectively-eradicate sorafenib-resistant hepatocellular carcinoma in vivo, J. Contr. Release, 331, 335, 10.1016/j.jconrel.2021.01.021 Ashley, 2013, Hydrogel drug delivery system with predictable and tunable drug release and degradation rates, Proc. Natl. Acad. Sci. USA, 110, 2318, 10.1073/pnas.1215498110 Schneider, 2016, Hydrogel Drug Delivery System Using Self-Cleaving Covalent Linkers for Once-a-Week Administration of Exenatide, Bioconjugate Chem., 27, 1210, 10.1021/acs.bioconjchem.5b00690 Barberio, 2020, Cancer Cell Coating Nanoparticles for Optimal Tumor-Specific Cytokine Delivery, ACS Nano, 14, 11238, 10.1021/acsnano.0c03109 Macdonald, 2011, Tissue integration of growth factor-eluting layer-by-layer polyelectrolyte multilayer coated implants, Biomaterials, 32, 1446, 10.1016/j.biomaterials.2010.10.052 Shah, 2014, Adaptive growth factor delivery from a polyelectrolyte coating promotes synergistic bone tissue repair and reconstruction, Proc. Natl. Acad. Sci. USA, 111, 12847, 10.1073/pnas.1408035111 Liu, 2023, Glucose-Responsive Charge-Switchable Lipid Nanoparticles for Insulin Delivery, Angew. Chem., Int. Ed. Engl., 62, e202303097, 10.1002/anie.202303097 Mateen, 2014, Injectable, in situ gelling, cyclodextrin–dextran hydrogels for the partitioning-driven release of hydrophobic drugs, J. Mater. Chem. B, 2, 5157, 10.1039/C4TB00631C Rodrigues de Azevedo, 2017, Modeling of the burst release from PLGA micro- and nanoparticles as function of physicochemical parameters and formulation characteristics, Int. J. Pharm., 532, 229, 10.1016/j.ijpharm.2017.08.118 Gao, 2011, Recent advances in materials for extended-release antibiotic delivery system, J. Antibiot., 64, 625, 10.1038/ja.2011.58 Kang, 2021, Drug–zein@lipid hybrid nanoparticles: Electrospraying preparation and drug extended release application, Colloids Surf. B Biointerfaces, 201, 111629, 10.1016/j.colsurfb.2021.111629 Volpatti, 2020, Glucose-responsive nanoparticles for rapid and extended self-regulated insulin delivery, ACS Nano, 14, 488, 10.1021/acsnano.9b06395 Yu, 2015, Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery, Proc. Natl. Acad. Sci. USA, 112, 8260, 10.1073/pnas.1505405112 Zhang, 2020, pH-sensitive MOF integrated with glucose oxidase for glucose-responsive insulin delivery, J. Contr. Release, 320, 159, 10.1016/j.jconrel.2020.01.038 Matsumoto, 2012, A Synthetic Approach Toward a Self-Regulated Insulin Delivery System, Angew. Chem., Int. Ed. Engl., 51, 2124, 10.1002/anie.201106252 Brownlee, 1979, A Glucose-Controlled Insulin-Delivery System: Semisynthetic Insulin Bound to Lectin, Science, 206, 1190, 10.1126/science.505005 Yang, 2022, Glucose-responsive microneedle patch for closed-loop dual-hormone delivery in mice and pigs, Sci. Adv., 8, eadd3197, 10.1126/sciadv.add3197 Wang, 2019, Charge-switchable polymeric complex for glucose-responsive insulin delivery in mice and pigs, Sci. Adv., 5, eaaw4357, 10.1126/sciadv.aaw4357 Li, 2016, Designing hydrogels for controlled drug delivery, Nat. Rev. Mater., 1, 16071, 10.1038/natrevmats.2016.71 Ahadian, 2020, Micro and nanoscale technologies in oral drug delivery, Adv. Drug Deliv. Rev., 157, 37, 10.1016/j.addr.2020.07.012 Mitchell, 2021, Engineering precision nanoparticles for drug delivery, Nat. Rev. Drug Discov., 20, 101, 10.1038/s41573-020-0090-8 Zhao, 2020, Targeting Strategies for Tissue-Specific Drug Delivery, Cell, 181, 151, 10.1016/j.cell.2020.02.001 Wang, 2020, Glucose-responsive insulin and delivery systems: innovation and translation, Adv. Mater., 32, 1902004, 10.1002/adma.201902004 Boland, 2001, Limitations of Conventional Methods of Self-Monitoring of Blood Glucose: Lessons learned from 3 days of continuous glucose sensing in pediatric patients with type 1 diabetes, Diabetes Care, 24, 1858, 10.2337/diacare.24.11.1858 Yoo, 2020, Phenomenology of the Initial Burst Release of Drugs from PLGA Microparticles, ACS Biomater. Sci. Eng., 6, 6053, 10.1021/acsbiomaterials.0c01228 Tam, 1993, Individual variation in first-pass metabolism, Clin. Pharmacokinet., 25, 300, 10.2165/00003088-199325040-00005 Baraona, 2001, Gender differences in pharmacokinetics of alcohol, Alcohol Clin. Exp. Res., 25, 502, 10.1111/j.1530-0277.2001.tb02242.x Wynne, 2005, Drug metabolism and ageing, J. Br. Menopause Soc., 11, 51, 10.1258/136218005775544589 Whyte, 2018, Sustained release of targeted cardiac therapy with a replenishable implanted epicardial reservoir, Nat. Biomed. Eng., 2, 416, 10.1038/s41551-018-0247-5 Sun, 2017, Closed-loop control of targeted ultrasound drug delivery across the blood–brain/tumor barriers in a rat glioma model, Proc. Natl. Acad. Sci. USA, 114, E10281, 10.1073/pnas.1713328114 Mickle, 2019, A wireless closed-loop system for optogenetic peripheral neuromodulation, Nature, 565, 361, 10.1038/s41586-018-0823-6 Choi, 2022, A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy, Science, 376, 1006, 10.1126/science.abm1703 Koo, 2020, Wirelessly controlled, bioresorbable drug delivery device with active valves that exploit electrochemically triggered crevice corrosion, Sci. Adv., 6, eabb1093, 10.1126/sciadv.abb1093 Steil, 2003, Closed loop system for controlling insulin infusion, Google Patents Dumont, 2013, Closed-loop control of anesthesia: a primer for anesthesiologists, Anesth. Analg., 117, 1130, 10.1213/ANE.0b013e3182973687 Zhang, 2023, Self-powered, light-controlled, bioresorbable platforms for programmed drug delivery, Proc. Natl. Acad. Sci. USA, 120 Joo, 2021, Soft implantable drug delivery device integrated wirelessly with wearable devices to treat fatal seizures, Sci. Adv., 7, eabd4639, 10.1126/sciadv.abd4639 Farra, 2012, First-in-Human Testing of a Wirelessly Controlled Drug Delivery Microchip, Sci. Transl. Med., 4, 122ra21, 10.1126/scitranslmed.3003276 Santini, 1999, A controlled-release microchip, Nature, 397, 335, 10.1038/16898 Roy, 2023, Infusion systems and methods for prospective closed-loop adjustments, Google Patents Santini, 1999, A controlled-release microchip, Nature, 397, 335, 10.1038/16898 Nadeau, 2017, Prolonged energy harvesting for ingestible devices, Nat. Biomed. Eng., 1, 0022, 10.1038/s41551-016-0022 Lee, 2016, A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy, Nat. Nanotechnol., 11, 566, 10.1038/nnano.2016.38 Abramson, 2022, A flexible electronic strain sensor for the real-time monitoring of tumor regression, Sci. Adv., 8, eabn6550, 10.1126/sciadv.abn6550 Nan, 2022, Mucosa-interfacing electronics, Nat. Rev. Mater., 7, 908, 10.1038/s41578-022-00477-2 Judy, 2001, Microelectromechanical systems (MEMS): fabrication, design and applications, Smart Mater. Struct., 10, 1115, 10.1088/0964-1726/10/6/301 Barnard, 2015, Future artificial pancreas technology for type 1 diabetes: what do users want?, Diabetes Technol. Therapeut., 17, 311, 10.1089/dia.2014.0316 Gresham, 2018, Wearable activity monitors to assess performance status and predict clinical outcomes in advanced cancer patients, NPJ Digit. Med., 1, 27, 10.1038/s41746-018-0032-6 Fulk, 2014, Accuracy of 2 activity monitors in detecting steps in people with stroke and traumatic brain injury, Phys. Ther., 94, 222, 10.2522/ptj.20120525 Blydt-Hansen, 2014, Medication treatment complexity and adherence in children with CKD, Clin. J. Am. Soc. Nephrol., 9, 247, 10.2215/CJN.05750513 Choudhry, 2011, The implications of therapeutic complexity on adherence to cardiovascular medications, Arch. Intern. Med., 171, 814 Trevitt, 2016, Artificial Pancreas Device Systems for the Closed-Loop Control of Type 1 Diabetes:What Systems Are in Development?, J. Diabetes Sci. Technol., 10, 714, 10.1177/1932296815617968 Zaouter, 2016, The Feasibility of a Completely Automated Total IV Anesthesia Drug Delivery System for Cardiac Surgery, Anesth. Analg., 123, 885, 10.1213/ANE.0000000000001152 Abramson, 2020, Ingestible transiently anchoring electronics for microstimulation and conductive signaling, Sci. Adv., 6, eaaz0127, 10.1126/sciadv.aaz0127 Kanderian, 2014, Apparatus and method for controlling insulin infusion with state variable feedback, Google Patents Ghita, 2020, Closed-loop control of anesthesia: Survey on actual trends, challenges and perspectives, IEEE Access, 8, 206264, 10.1109/ACCESS.2020.3037725 Xu, 2021, Battery-Free and Wireless Smart Wound Dressing for Wound Infection Monitoring and Electrically Controlled On-Demand Drug Delivery, Adv. Funct. Mater., 31, 2100852, 10.1002/adfm.202100852 Linhares, 2013, One-step tunneling of DBS extensions—a technical note, Acta Neurochir., 155, 837, 10.1007/s00701-013-1667-3 Fontaine, 2013, Two-step tunneling technique of deep brain stimulation extension wires—a description, Acta Neurochir., 155, 2399, 10.1007/s00701-013-1870-2 Miller, 2009, Wire tethering or ‘bowstringing’as a long-term hardware-related complication of deep brain stimulation, Stereotact. Funct. Neurosurg., 87, 353, 10.1159/000236369 Voges, 2006, Deep-brain stimulation: long-term analysis of complications caused by hardware and surgery—experiences from a single centre, J. Neurol. Neurosurg. Psychiatry, 77, 868, 10.1136/jnnp.2005.081232 WIEGAND, 2003, Long-Term Complication Rates in Ventricular, Single Lead VDD, and Dual Chamber Pacing, Pacing Clin. Electrophysiol., 26, 1961, 10.1046/j.1460-9592.2003.00303.x Kirkfeldt, 2014, Complications after cardiac implantable electronic device implantations: an analysis of a complete, nationwide cohort in Denmark, Eur. Heart J., 35, 1186, 10.1093/eurheartj/eht511 Xie, 2020, Flexible and Stretchable Antennas for Biointegrated Electronics, Adv. Mater., 32, 1902767, 10.1002/adma.201902767 Borton, 2013, An implantable wireless neural interface for recording cortical circuit dynamics in moving primates, J. Neural. Eng., 10, 026010, 10.1088/1741-2560/10/2/026010 Gilron, 2021, Long-term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with Parkinson’s disease, Nat. Biotechnol., 39, 1078, 10.1038/s41587-021-00897-5 Boutry, 2019, Biodegradable and flexible arterial-pulse sensor for the wireless monitoring of blood flow, Nat. Biomed. Eng., 3, 47, 10.1038/s41551-018-0336-5 Ziskin, 2018, Tissue models for RF exposure evaluation at frequencies above 6 GHz, Bioelectromagnetics, 39, 173, 10.1002/bem.22110 Song, 2023, Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites, Sci. Adv., 9, eade4687, 10.1126/sciadv.ade4687 Nappi, 2021, 1 He, 2019, 25, 236 Chen, 2016, Passive E-Textile UHF RFID-Based Wireless Strain Sensors With Integrated References, IEEE Sensor. J., 16, 7835, 10.1109/JSEN.2016.2608659 Álvarez López, 2018, RFID technology for management and tracking: E-health applications, Sensors, 18, 2663, 10.3390/s18082663 Food, 2014 Walters, 2000, Heating and pain sensation produced in human skin by millimeter waves: comparison to a simple thermal model, Health Phys., 78, 259, 10.1097/00004032-200003000-00003 2020, Guidelines for Limiting Exposure to Electromagnetic Fields (100 kHz to 300 GHz), Health Phys., 118, 483, 10.1097/HP.0000000000001210 Kim, 2021, Soft subdermal implant capable of wireless battery charging and programmable controls for applications in optogenetics, Nat. Commun., 12, 535, 10.1038/s41467-020-20803-y Chung, 2020, Skin-interfaced biosensors for advanced wireless physiological monitoring in neonatal and pediatric intensive-care units, Nat. Med., 26, 418, 10.1038/s41591-020-0792-9 Huang, 2018, Three-dimensional integrated stretchable electronics, Nat. Electron., 1, 473, 10.1038/s41928-018-0116-y Chung, 2019, Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care, Science, 363, eaau0780, 10.1126/science.aau0780 Lee, 2018, Highly flexible, wearable, and disposable cardiac biosensors for remote and ambulatory monitoring, NPJ Digit. Med., 1, 2, 10.1038/s41746-017-0009-x Zhang, 2019, Wireless, battery-free optoelectronic systems as subdermal implants for local tissue oximetry, Sci. Adv., 5, eaaw0873, 10.1126/sciadv.aaw0873 Zhang, 2019, Battery-free, lightweight, injectable microsystem for in vivo wireless pharmacology and optogenetics, Proc. Natl. Acad. Sci. USA, 116, 21427, 10.1073/pnas.1909850116 Gutruf, 2019, Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models, Nat. Commun., 10, 5742, 10.1038/s41467-019-13637-w Madhvapathy, 2020, Reliable, low-cost, fully integrated hydration sensors for monitoring and diagnosis of inflammatory skin diseases in any environment, Sci. Adv., 6, eabd7146, 10.1126/sciadv.abd7146 Kwak, 2020, Wireless sensors for continuous, multimodal measurements at the skin interface with lower limb prostheses, Sci. Transl. Med., 12, eabc4327, 10.1126/scitranslmed.abc4327 Movassaghi, 2014, Wireless Body Area Networks: A Survey, IEEE Commun. Surv. Tutorials, 16, 1658, 10.1109/SURV.2013.121313.00064 Kang, 2016, Bioresorbable silicon electronic sensors for the brain, Nature, 530, 71, 10.1038/nature16492 Kim, 2015, Miniaturized flexible electronic systems with wireless power and near-field communication capabilities, Adv. Funct. Mater., 25, 4761, 10.1002/adfm.201501590 Ku, 2020, Smart, soft contact lens for wireless immunosensing of cortisol, Sci. Adv., 6, eabb2891, 10.1126/sciadv.abb2891 Olenik, 2021, The future of near-field communication-based wireless sensing, Nat. Rev. Mater., 6, 286, 10.1038/s41578-021-00299-8 Teengam, 2021, NFC-enabling smartphone-based portable amperometric immunosensor for hepatitis B virus detection, Sensor. Actuator. B Chem., 326, 128825, 10.1016/j.snb.2020.128825 Rwei, 2017, Ultrasound-triggered local anaesthesia, Nat. Biomed. Eng., 1, 644, 10.1038/s41551-017-0117-6 Bar-Zion, 2021, Acoustically triggered mechanotherapy using genetically encoded gas vesicles, Nat. Nanotechnol., 16, 1403, 10.1038/s41565-021-00971-8 Lee, 2022, Spatially targeted brain cancer immunotherapy with closed-loop controlled focused ultrasound and immune checkpoint blockade, Sci. Adv., 8, eadd2288, 10.1126/sciadv.add2288 Tabak, 2021, Video-Capable Ultrasonic Wireless Communications Through Biological Tissues, IEEE Trans. Ultrason. Ferroelectrics Freq. Control, 68, 664, 10.1109/TUFFC.2020.3020776 Charthad, 2015, A mm-Sized Implantable Medical Device (IMD) With Ultrasonic Power Transfer and a Hybrid Bi-Directional Data Link, IEEE J. Solid State Circ., 50, 1741, 10.1109/JSSC.2015.2427336 Mitragotri, 1995, Ultrasound-mediated transdermal protein delivery, Science (New York, N.Y.), 269, 850, 10.1126/science.7638603 Schoellhammer, 2017, Defining optimal permeant characteristics for ultrasound-mediated gastrointestinal delivery, J. Contr. Release, 268, 113, 10.1016/j.jconrel.2017.10.023 Schoellhammer, 2017, Ultrasound-Mediated Delivery of RNA to Colonic Mucosa of Live Mice, Gastroenterology, 152, 1151, 10.1053/j.gastro.2017.01.002 Schoellhammer, 2015, Ultrasound-mediated gastrointestinal drug delivery, Sci. Transl. Med., 7, 310ra168, 10.1126/scitranslmed.aaa5937 France, 2019, Ultra-rapid drug delivery in the oral cavity using ultrasound, J. Contr. Release, 304, 1, 10.1016/j.jconrel.2019.04.037 Hu, 2023, A wearable cardiac ultrasound imager, Nature, 613, 667, 10.1038/s41586-022-05498-z Wang, 2022, Bioadhesive ultrasound for long-term continuous imaging of diverse organs, Science, 377, 517, 10.1126/science.abo2542 Zhao, 2022, Ionic communication for implantable bioelectronics, Sci. Adv., 8, eabm7851, 10.1126/sciadv.abm7851 Zhang, 2023, Wirelessly powered deformable electronic stent for noninvasive electrical stimulation of lower esophageal sphincter, Sci. Adv., 9, eade8622, 10.1126/sciadv.ade8622 Yang, 2021, Powering Implantable and Ingestible Electronics, Adv. Funct. Mater., 31, 2009289, 10.1002/adfm.202009289 Dagdeviren, 2014, Conformal piezoelectric energy harvesting and storage from motions of the heart, lung, and diaphragm, Proc. Natl. Acad. Sci. USA, 111, 1927, 10.1073/pnas.1317233111 Liu, 2022, Exercise-induced piezoelectric stimulation for cartilage regeneration in rabbits, Sci. Transl. Med., 14, eabi7282, 10.1126/scitranslmed.abi7282 Raman, 2020, Light-degradable hydrogels as dynamic triggers for gastrointestinal applications, Sci. Adv., 6, eaay0065, 10.1126/sciadv.aay0065 Benhamou, 2019, Closed-loop insulin delivery in adults with type 1 diabetes in real-life conditions: a 12-week multicentre, open-label randomised controlled crossover trial, Lancet. Digit. Health, 1, e17, 10.1016/S2589-7500(19)30003-2 2020, Standards of Medical Care in Diabetes-2020, Diabetes Care, 43 Templer, 2022, Closed-loop insulin delivery systems: past, present, and future directions, Front. Endocrinol., 13, 919942, 10.3389/fendo.2022.919942 Christiansen, 2017, Accuracy of a Fourth-Generation Subcutaneous Continuous Glucose Sensor, Diabetes Technol. Therapeut., 19, 446, 10.1089/dia.2017.0087 Garg, 2017, Glucose outcomes with the in-home use of a hybrid closed-loop insulin delivery system in adolescents and adults with type 1 diabetes, Diabetes Technol. Therapeut., 19, 155, 10.1089/dia.2016.0421 Díaz-Balzac, 2022, Continuous Subcutaneous Insulin Infusions: Closing the Loop, J. Clin. Endocrinol. Metab., 108, 1019, 10.1210/clinem/dgac746 ElSayed, 2023, 7. Diabetes Technology: Standards of Care in Diabetes—2023, Diabetes Care, 46, S111, 10.2337/dc23-S007 Huang, 2022, An automated all-in-one system for carbohydrate tracking, glucose monitoring, and insulin delivery, J. Contr. Release, 343, 31, 10.1016/j.jconrel.2022.01.001 Shirzaei Sani, 2023, A stretchable wireless wearable bioelectronic system for multiplexed monitoring and combination treatment of infected chronic wounds, Sci. Adv., 9, eadf7388, 10.1126/sciadv.adf7388 Hemmerling, 2013, Evaluation of a novel closed-loop total intravenous anaesthesia drug delivery system: a randomized controlled trial, Br. J. Anaesth., 110, 1031, 10.1093/bja/aet001 Perez, 2019, Large-Scale Assessment of a Smartwatch to Identify Atrial Fibrillation, N. Engl. J. Med., 381, 1909, 10.1056/NEJMoa1901183 Yenikomshian, 2019, Cardiac arrhythmia detection outcomes among patients monitored with the Zio patch system: a systematic literature review, Curr. Med. Res. Opin., 35, 1659, 10.1080/03007995.2019.1610370 Seo, 2022, Real-time monitoring of drug pharmacokinetics within tumor tissue in live animals, Sci. Adv., 8, eabk2901, 10.1126/sciadv.abk2901 Jonas, 2015, An implantable microdevice to perform high-throughput in vivo drug sensitivity testing in tumors, Sci. Transl. Med., 7, 284ra57, 10.1126/scitranslmed.3010564 Lu, 2020, Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy, Sci. Transl. Med., 12, 6606, 10.1126/scitranslmed.aaz6606 Kokkinos, 2019, Association of Closed-Loop Brain Stimulation Neurophysiological Features With Seizure Control Among Patients With Focal Epilepsy, JAMA Neurol., 76, 800, 10.1001/jamaneurol.2019.0658 Kang, 2022, Closed-loop direct control of seizure focus in a rodent model of temporal lobe epilepsy via localized electric fields applied sequentially, Nat. Commun., 13, 7805, 10.1038/s41467-022-35540-7 McCallum, 2013, Gastric electrical stimulation with Enterra therapy improves symptoms of idiopathic gastroparesis, Neuro Gastroenterol. Motil., 25, 815, 10.1111/nmo.12185 Dagdeviren, 2018, Miniaturized neural system for chronic, local intracerebral drug delivery, Sci. Transl. Med., 10, eaan2742, 10.1126/scitranslmed.aan2742 Sharma, 2023, Location-aware ingestible microdevices for wireless monitoring of gastrointestinal dynamics, Nat. Electron., 6, 242, 10.1038/s41928-023-00916-0 Kim, 2019, Wearable biosensors for healthcare monitoring, Nat. Biotechnol., 37, 389, 10.1038/s41587-019-0045-y Min, 2023, Skin-Interfaced Wearable Sweat Sensors for Precision Medicine, Chem. Rev., 123, 5049, 10.1021/acs.chemrev.2c00823 Abramson, 2022, Oral delivery of systemic monoclonal antibodies, peptides and small molecules using gastric auto-injectors, Nat. Biotechnol., 40, 103, 10.1038/s41587-021-01024-0 Bellinger, 2016, Oral, ultra-long lasting drug delivery: Application toward malaria elimination goals, Sci. Transl. Med., 8, 365ra157, 10.1126/scitranslmed.aag2374 Dhalla, 2022, A robotic pill for oral delivery of biotherapeutics: safety, tolerability, and performance in healthy subjects, Drug Deliv. Transl. Res., 12, 294, 10.1007/s13346-021-00938-1 Ghosh, 2020, Gastrointestinal-resident, shape-changing microdevices extend drug release in vivo, Sci. Adv., 6, eabb4133, 10.1126/sciadv.abb4133 Srinivasan, 2022, RoboCap: Robotic mucus-clearing capsule for enhanced drug delivery in the gastrointestinal tract, Sci. Robot., 7, eabp9066, 10.1126/scirobotics.abp9066 Abramson, 2022, Oral mRNA delivery using capsule-mediated gastrointestinal tissue injections, Matter, 5, 975, 10.1016/j.matt.2021.12.022 Wang, 2022, Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring, Sci. Adv., 8, eabk0967, 10.1126/sciadv.abk0967 Yang, 2020, A laser-engraved wearable sensor for sensitive detection of uric acid and tyrosine in sweat, Nat. Biotechnol., 38, 217, 10.1038/s41587-019-0321-x Chan, 2021, Closed-loop wearable naloxone injector system, Sci. Rep., 11, 22663, 10.1038/s41598-021-01990-0 Ghosh, 2018, Addressing Unmet Clinical Needs with 3D Printing Technologies, Adv. Healthcare Mater., 7, 1800417, 10.1002/adhm.201800417 Li, 2008, Retention of the capsule endoscope: a single-center experience of 1000 capsule endoscopy procedures, Gastrointest. Endosc., 68, 174, 10.1016/j.gie.2008.02.037 Bass, 2002, Gastrointestinal safety of an extended-release, nondeformable, oral dosage form (OROS: a retrospective study, Drug Saf., 25, 1021, 10.2165/00002018-200225140-00004 Lee, 2023, Wireless, Fully Implantable and Expandable Electronic System for Bidirectional Electrical Neuromodulation of the Urinary Bladder, ACS Nano, 17, 8511, 10.1021/acsnano.3c00755 Quintero, 2014, 26, 532 Iulian, 2016 Mackanic, 2019, Decoupling of mechanical properties and ionic conductivity in supramolecular lithium ion conductors, Nat. Commun., 10, 5384, 10.1038/s41467-019-13362-4 Liu, 2017, Characterizing Smartwatch Usage in the Wild Moerke, 2022, New strategies for energy supply of cardiac implantable devices, Herzschrittmachertherap. Elektrophysiol., 33, 224, 10.1007/s00399-022-00852-0 Lee, 2021, Implantable system for chronotherapy, Sci. Adv., 7, eabj4624, 10.1126/sciadv.abj4624 Kang, 2023, Penetrative and Sustained Drug Delivery Using Injectable Hydrogel Nanocomposites for Postsurgical Brain Tumor Treatment, ACS Nano, 17, 5435, 10.1021/acsnano.2c10094 Leong, 2009, Tetherless thermobiochemically actuated microgrippers, Proc. Natl. Acad. Sci. USA, 106, 703, 10.1073/pnas.0807698106 Lee, 2019, Flexible, sticky, and biodegradable wireless device for drug delivery to brain tumors, Nat. Commun., 10, 5205, 10.1038/s41467-019-13198-y Zhou, 2020, Stretchable piezoelectric energy harvesters and self-powered sensors for wearable and implantable devices, Biosens. Bioelectron., 168, 112569, 10.1016/j.bios.2020.112569 Garland, N.T., Kaveti, R., and Bandodkar, A.J. Biofluid-Activated Biofuel Cells, Batteries, and Supercapacitors – A Comprehensive Review. Advanced Materials n/a, 2303197. 10.1002/adma.202303197. Pandey, 2010, A Fully Integrated RF-Powered Contact Lens With a Single Element Display, IEEE Trans. Biomed. Circuits Syst., 4, 454, 10.1109/TBCAS.2010.2081989 Liu, 2014, Design and Safety Considerations of an Implantable Rectenna for Far-Field Wireless Power Transfer, IEEE Trans. Antenn. Propag., 62, 5798, 10.1109/TAP.2014.2352363 Diego, 2017, Axillary migration of Nexplanon®: Case report, Contraception, 95, 218, 10.1016/j.contraception.2016.11.002 Monge, 2017, Localization of microscale devices in vivo using addressable transmitters operated as magnetic spins, Nat. Biomed. Eng., 1, 736, 10.1038/s41551-017-0129-2 Sun, 2014, Closed-loop neurostimulation: the clinical experience, Neurotherapeutics, 11, 553, 10.1007/s13311-014-0280-3 Longras, 2020, 1 Brito, 2021, 1 Zaldivar, 2020, 0488 Lounis, 2020, Attacks and defenses in short-range wireless technologies for IoT, IEEE Access, 8, 88892, 10.1109/ACCESS.2020.2993553 Luo, 2019, 3454 Gollakota, 2011, 2 Denning, 2008 Zheng, 2014, 647 Zheng, 2017, 1 Zheng, 2017, Ideas and Challenges for Securing Wireless Implantable Medical Devices: A Review, IEEE Sensor. J., 17, 562, 10.1109/JSEN.2016.2633973 Ciuti, 2011, Capsule endoscopy: from current achievements to open challenges, IEEE Rev. Biomed. Eng., 4, 59, 10.1109/RBME.2011.2171182 Chae, 2009, A 128-channel 6 mW wireless neural recording IC with spike feature extraction and UWB transmitter, IEEE Trans. Neural Syst. Rehabil. Eng., 17, 312, 10.1109/TNSRE.2009.2021607 Anh, 2010, 16, 160 Tang, 2010, 1 Panescu, 2008, Emerging Technologies [wireless communication systems for implantable medical devices], IEEE Eng. Med. Biol. Mag., 27, 96, 10.1109/EMB.2008.915488 Inui, 2015, A Miniaturized Flexible Antenna Printed on a High Dielectric Constant Nanopaper Composite, Adv. Mater., 27, 1112, 10.1002/adma.201404555 Chen, 2019, Graphene-Based Actuator with Integrated-Sensing Function, Adv. Funct. Mater., 29, 1806057, 10.1002/adfm.201806057 Zhang, 2020, Deep learning-enabled triboelectric smart socks for IoT-based gait analysis and VR applications, Cell. Mol. Biol. Lett., 25, 29, 10.1186/s11658-020-00221-0 Schwartz, 2013, Flexible polymer transistors with high pressure sensitivity for application in electronic skin and health monitoring, Nat. Commun., 4, 1859, 10.1038/ncomms2832 Fan, 2020, Machine-knitted washable sensor array textile for precise epidermal physiological signal monitoring, Sci. Adv., 6, eaay2840, 10.1126/sciadv.aay2840 Kwon, 2023, At-home wireless sleep monitoring patches for the clinical assessment of sleep quality and sleep apnea, Sci. Adv., 9, eadg9671, 10.1126/sciadv.adg9671 Mannoor, 2012, Graphene-based wireless bacteria detection on tooth enamel, Nat. Commun., 3, 763, 10.1038/ncomms1767 Bariya, 2020, Glove-based sensors for multimodal monitoring of natural sweat, Sci. Adv., 6, eabb8308, 10.1126/sciadv.abb8308 Li, 2022, Microneedle patch tattoos, iScience, 25, 105014, 10.1016/j.isci.2022.105014 Shi, 2020, Microneedle-mediated gene delivery for the treatment of ischemic myocardial disease, Sci. Adv., 6, eaaz3621, 10.1126/sciadv.aaz3621 Than, 2018, Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery, Nat. Commun., 9, 4433, 10.1038/s41467-018-06981-w Zhang, 2019, Climbing-inspired twining electrodes using shape memory for peripheral nerve stimulation and recording, Sci. Adv., 5, eaaw1066, 10.1126/sciadv.aaw1066 Whyte, 2022, Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform, Nat. Commun., 13, 4496, 10.1038/s41467-022-32147-w Mann, 2006, External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities, Google Patents