Các thuốc chẹn thụ thể angiotensin phổ biến có thể điều chỉnh trực tiếp hệ thống miễn dịch qua VDR, PPAR và CCR2b
Tóm tắt
Có những dấu hiệu cho thấy các thuốc chẹn thụ thể angiotensin (ARBs) phổ biến có thể có tác dụng kháng viêm bằng cách điều chỉnh trực tiếp hệ thống miễn dịch. Chúng tôi quyết định sử dụng mô hình phân tử để nhanh chóng đánh giá các mục tiêu tiềm năng nào có thể biện minh cho chi phí xác thực trong phòng thí nghiệm chi tiết. Chúng tôi trước tiên nghiên cứu thụ thể hạt nhân VDR, được kích hoạt bởi hormone secosteroid 1,25-dihydroxyvitamin-D. Thụ thể này trung gian cho việc biểu hiện các chất điều chỉnh phổ biến như GnRH (hormone giải phóng gonadotrophin) và hormone cận giáp (PTH). Ngoài ra, chúng tôi còn xem xét Thụ thể kích hoạt peroxisome gamma (PPARgamma), có ảnh hưởng đến chức năng của các tế bào thực bào, và Thụ thể C-Chemokine, loại 2b (CCR2b), giúp thu hút mono bào đến vị trí thách thức miễn dịch viêm.
Từ khóa
#ARBs #VDR #PPARgamma #CCR2b #kháng viêm #mô hình phân tử #thụ thể hạt nhân #thuốc tim mạchTài liệu tham khảo
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