Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Nature - Tập 504 Số 7480 - Trang 446-450 - 2013
Yukihiro Furusawa1, Yuichi Obata1, Shinji Fukuda1, Takaho A. Endo1, Gaku Nakato1, Daisuke Takahashi1, Yumiko Nakanishi2, Chikako Uetake1, Keiko Kato1, Tamotsu Kato1, Mayuko Takahashi1, Noriko Fukuda2, Shinnosuke Murakami2, Eiji Miyauchi1, Shingo Hino3, Koji Atarashi1, Satoshi Onawa1, Y Fujimura4, Trevor Lockett5, Julie M. Clarke5, David L. Topping5, Masaru Tomita2, Shohei Hori1, Osamu Ohara1, Tatsuya Morita3, Haruhiko Koseki6, Jun Kikuchi7, Kenya Honda1, Koji Hase4, Hiroshi Ohno7
1RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan ,
2Institute for Advanced Biosciences, Keio University, Yamagata 997-0052, Japan
3Faculty of Agriculture, Shizuoka University, Shizuoka 422-8529, Japan
4The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
5Preventative Health National Research Flagship, CSIRO Food and Nutritional Sciences, South Australia 5000, Australia ,
6Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
7Graduate School of Medical Life Science, Yokohama City University, Kanagawa, 230-0045, Japan

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