Combining thioridazine and loratadine for the treatment of gastrointestinal tumor
Tóm tắt
Từ khóa
Tài liệu tham khảo
Chen, 2017, Cancer incidence and mortality in China, 2013, Cancer Lett, 401, 63, 10.1016/j.canlet.2017.04.024
Fitzgerald, 2006, Systems biology and combination therapy in the quest for clinical efficacy, Nat Chem Biol, 2, 458, 10.1038/nchembio817
Schnipper, 2015, American society of clinical oncology statement: A conceptual framework to assess the value of cancer treatment options, J Clin Oncol, 33, 2563, 10.1200/JCO.2015.61.6706
Sgambato, 2016, Gut-brain axis in gastric mucosal damage and protection, Curr Neuropharmacol, 14, 959, 10.2174/1570159X14666160223120742
Grubišić, 2017, Enteric glia regulate gut motility in health and disease, Brain Res Bull, 10.1016/j.brainresbull.2017.03.011
Keightley, 2015, Pathways in gut-brain communication: Evidence for distinct gut-to-brain and brain-to-gut syndromes, Aust N Z J Psychiatry, 49, 207, 10.1177/0004867415569801
Sachlos, 2012, Identification of drugs including a dopamine antagonist that selectively target cancer stem cells, Cell, 149, 1284, 10.1016/j.cell.2012.03.049
Mu, 2014, Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer, Oncol Rep, 31, 2107, 10.3892/or.2014.3068
Ke, 2014, Co-delivery of thioridazine and doxorubicin using polymeric micelles for targeting both cancer cells and cancer stem cells, Biomaterials, 35, 1096, 10.1016/j.biomaterials.2013.10.049
Park, 2014, Thioridazine inhibits angiogenesis and tumor growth by targeting the VEGFR-2/PI3K/mTOR pathway in ovarian cancer xenografts, Oncotarget, 5, 4929, 10.18632/oncotarget.2063
Kang, 2012, Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells, Apoptosis, 17, 989, 10.1007/s10495-012-0717-2
Chen, 2006, Checkpoint kinase 1-mediated phosphorylation of Cdc25C and bad proteins are involved in antitumor effects of loratadine-induced G2/M phase cell-cycle arrest and apoptosis, Mol Carcinog, 45, 461, 10.1002/mc.20165
Chou, 2010, Drug combination studies and their synergy quantification using the Chou-Talalay method, Cancer Res, 70, 440, 10.1158/0008-5472.CAN-09-1947
Lin, 2014, Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers, Proc Natl Acad Sci USA, 111, E4504, 10.1073/pnas.1408759111
Livak, 2001, Analysis of relative gene expression data using real time quantitative PCR and the 2(−Delta Delta C(T)) method, Methods, 25, 402, 10.1006/meth.2001.1262
Strobl, 1990, Inhibition of human breast cancer cell proliferation in tissue culture by the neuroleptic agents pimozide and thioridazine, Cancer Res, 50, 5399
Gil-Ad, 2004, Characterization of phenothiazine-induced apoptosis in neuroblastoma and glioma cell lines: Clinical relevance and possible application for brain-derived tumors, J Mol Neurosci, 22, 189, 10.1385/JMN:22:3:189
Zhelev, 2004, Phenothiazines suppress proliferation and induce apoptosis in cultured leukemic cell without any influence on the viability of normal lymphocytes. Phenothiazines and leukemia, Cancer Chemother Pharmacol, 53, 267, 10.1007/s00280-003-0738-1
Plati, 2011, Apoptotic cell signaling in cancer progression and therapy, Integr Biol (Camb), 3, 279, 10.1039/c0ib00144a
Wong, 2011, Apoptosis in cancer: From pathogenesis to treatment, J Exp Clin Cancer Res, 30, 87, 10.1186/1756-9966-30-87
Riedl, 2004, Molecular mechanisms of caspase regulation during apoptosis, Nat Rev Mol Cell Biol, 5, 897, 10.1038/nrm1496
de Melo, 2017, A review of mTOR pathway inhibitors in gynecologic cancer, Oxid Med Cell Longev, 2017, 4809751, 10.1155/2017/4809751
Hu, 2005, Phosphatidylinositol 3-kinase mediates angiogenesis and vascular permeability associated with ovarian carcinoma, Clin Cancer Res, 11, 8208, 10.1158/1078-0432.CCR-05-0206
Shi, 1995, Rapamycin enhances apoptosis and increases sensitivity to cisplatin in vitro, Cancer Res, 55, 1982
Cantley, 2002, The phosphoinositide 3-kinase pathway, Science, 296, 1655, 10.1126/science.296.5573.1655
King, 2015, PI3King the lock: Targeting the PI3K/Akt/mTOR pathway as a novel therapeutic strategy in neuroblastoma, J Pediatr Hematol Oncol, 37, 245, 10.1097/MPH.0000000000000329
Cardone, 1998, Regulation of cell death protease caspase-9 by phosphorylation, Science, 282, 1318, 10.1126/science.282.5392.1318
Brunet, 1999, Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor, Cell, 96, 857, 10.1016/S0092-8674(00)80595-4
Rafalski, 2011, Energy metabolism in adult neural stem cell fate, Prog Neurobiol, 93, 182, 10.1016/j.pneurobio.2010.10.007
Brown, 1994, A mammalian protein targeted by G1-arresting rapamycin-receptor complex, Nature, 369, 756, 10.1038/369756a0
Sabatini, 1994, RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs, Cell, 78, 35, 10.1016/0092-8674(94)90570-3
Wan, 2007, Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism, Oncogene, 26, 1932, 10.1038/sj.onc.1209990