Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission

Cell Reports - Tập 23 - Trang 2509-2523 - 2018
Ralda Nehme1,2, Emanuela Zuccaro1,2, Sulagna Dia Ghosh1,2, Chenchen Li1, John L. Sherwood1,2, Olli Pietilainen1,2, Lindy E. Barrett1,2, Francesco Limone1,2, Kathleen A. Worringer3, Sravya Kommineni3, Ying Zang1, Davide Cacchiarelli2, Alex Meissner2, Rolf Adolfsson4, Stephen Haggarty5, Jon Madison1, Matthias Muller6, Paola Arlotta1,2, Zhanyan Fu1, Guoping Feng1,7
1Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
2Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
3Novartis Institutes for Biomedical Research, Novartis, Cambridge, MA 02139, USA
4Umea University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry, 901 85 Umea, Sweden
5Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
6Novartis Institutes for Biomedical Research, Novartis, 4056 Basel, Switzerland
7McGovern Institute for Brain Research in the Department of Brain and Cognitive Sciences at MIT, Cambridge, MA, 02139, USA

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