Combined use of ordered mesoporous silica and precipitation inhibitors for improved oral absorption of the poorly soluble weak base itraconazole

Michiel Van Speybroeck1, Raf Mols1, Randy Mellaerts2, Thao Do Thi1, Johan A. Martens2, Jan Van Humbeeck3, Pieter Annaert1, Guy Van den Mooter1, Patrick Augustijns1
1Laboratory for Pharmacotechnology and Biopharmacy, Katholieke Universiteit Leuven, Leuven, Belgium
2Centre for Surface Chemistry and Catalysis, Katholieke Universiteit Leuven, Heverlee, Belgium
3Department of Metallurgy and Materials Engineering, Katholieke Universiteit Leuven, Heverlee, Belgium