Combined BRM270 and endostatin inhibit relapse of NSCLC while suppressing lung cancer stem cell proliferation induced by endostatin

Molecular Therapy - Oncolytics - Tập 22 - Trang 565-573 - 2021
Yan-hui Gu1,2, Yong-chun Shen1, Yao Ou-yang2, Xi-min Rao2, Dan-dan Fu2, Fu-qiang Wen1
1Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China
2Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou 563000, China

Tài liệu tham khảo

Jemal, 2011, Global cancer statistics, CA Cancer J. Clin., 61, 69, 10.3322/caac.20107 William, 2009, Revisiting stage IIIB and IV non-small cell lung cancer: analysis of the surveillance, epidemiology, and end results data, Chest, 136, 701, 10.1378/chest.08-2968 Gridelli, 2010, Recent issues in first-line treatment of advanced non-small-cell lung cancer: Results of an International Expert Panel Meeting of the Italian Association of Thoracic Oncology, Lung Cancer, 68, 319, 10.1016/j.lungcan.2009.11.018 Wang, 2005, [Results of randomized, multicenter, double-blind phase III trial of rh-endostatin (YH-16) in treatment of advanced non-small cell lung cancer patients], Zhongguo Fei Ai Za Zhi, 8, 283 Chen, 2014, Endostar, a novel human recombinant endostatin, attenuates liver fibrosis in CCl4-induced mice, Exp. Biol. Med. (Maywood), 239, 998, 10.1177/1535370214532595 Yu, 2016, Antiangiogenic therapy using endostatin increases the number of ALDH+ lung cancer stem cells by generating intratumor hypoxia, Sci. Rep., 6, 34239, 10.1038/srep34239 Mongre, 2015, The novel inhibitor BRM270 downregulates tumorigenesis by suppression of NF-κB signaling cascade in MDR-induced stem like cancer-initiating cells, Int. J. Oncol., 46, 2573, 10.3892/ijo.2015.2961 Kwon, 2018, BRM270 inhibits cancer stem cell maintenance via microRNA regulation in chemoresistant A549 lung adenocarcinoma cells, Cell Death Dis., 9, 244, 10.1038/s41419-018-0277-7 Lagos-Quintana, 2001, Identification of novel genes coding for small expressed RNAs, Science, 294, 853, 10.1126/science.1064921 Lee, 2001, An extensive class of small RNAs in Caenorhabditis elegans, Science, 294, 862, 10.1126/science.1065329 Blower, 2008, MicroRNAs modulate the chemosensitivity of tumor cells, Mol. Cancer Ther., 7, 1, 10.1158/1535-7163.MCT-07-0573 Godlewski, 2008, Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal, Cancer Res., 68, 9125, 10.1158/0008-5472.CAN-08-2629 Zhu, 2011, Reduced miR-128 in breast tumor-initiating cells induces chemotherapeutic resistance via Bmi-1 and ABCC5, Clin. Cancer Res., 17, 7105, 10.1158/1078-0432.CCR-11-0071 Shan, 2016, miR128-1 inhibits the growth of glioblastoma multiforme and glioma stem-like cells via targeting BMI1 and E2F3, Oncotarget, 7, 78813, 10.18632/oncotarget.12385 Jiang, 2016, MiR-128 reverses the gefitinib resistance of the lung cancer stem cells by inhibiting the c-met/PI3K/AKT pathway, Oncotarget, 7, 73188, 10.18632/oncotarget.12283 Jeon, 2017, BRM270, a Compound from Natural Plant Extracts, Inhibits Glioblastoma Stem Cell Properties and Glioblastoma Recurrence, J. Med. Food, 20, 838, 10.1089/jmf.2017.3929 Bonnet, 1997, Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell, Nat. Med., 3, 730, 10.1038/nm0797-730 Giangreco, 2009, Stem cells are dispensable for lung homeostasis but restore airways after injury, Proc. Natl. Acad. Sci. USA, 106, 9286, 10.1073/pnas.0900668106 Clarke, 2006, Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells, Cancer Res., 66, 9339, 10.1158/0008-5472.CAN-06-3126 Hu, 2014, microRNA-128 plays a critical role in human non-small cell lung cancer tumourigenesis, angiogenesis and lymphangiogenesis by directly targeting vascular endothelial growth factor-C, Eur. J. Cancer, 50, 2336, 10.1016/j.ejca.2014.06.005 Guo, 2016, Cranberry Extract Standardized for Proanthocyanidins Alleviates β-Amyloid Peptide Toxicity by Improving Proteostasis Through HSF-1 in Caenorhabditis elegans Model of Alzheimer’s Disease, J. Gerontol. A Biol. Sci. Med. Sci., 71, 1564, 10.1093/gerona/glv165 Cortes-Dericks, 2010, Putative cancer stem cells in malignant pleural mesothelioma show resistance to cisplatin and pemetrexed, Int. J. Oncol., 37, 437 Jin, 2014, miRNA-128 suppresses prostate cancer by inhibiting BMI-1 to inhibit tumor-initiating cells, Cancer Res., 74, 4183, 10.1158/0008-5472.CAN-14-0404 Abdouh, 2009, BMI1 sustains human glioblastoma multiforme stem cell renewal, J. Neurosci., 29, 8884, 10.1523/JNEUROSCI.0968-09.2009 Mongre, 2016, Epigenetic induction of epithelial to mesenchymal transition by LCN2 mediates metastasis and tumorigenesis, which is abrogated by NF-κB inhibitor BRM270 in a xenograft model of lung adenocarcinoma, Int. J. Oncol., 48, 84, 10.3892/ijo.2015.3245