Combinatory antitumor therapy by cascade targeting of a single drug

Mei, 2019, Actively priming autophagic cell death with novel transferrin receptor-targeted nanomedicine for synergistic chemotherapy against breast cancer, Acta Pharm Sin B, 9, 1061, 10.1016/j.apsb.2019.03.006 Hu, 2015, Recent advances of cocktail chemotherapy by combination drug delivery systems, Adv Drug Deliv Rev, 98, 19, 10.1016/j.addr.2015.10.022 Parhi, 2012, Nanotechnology-based combinational drug delivery: an emerging approach for cancer therapy, Drug Discov Today, 17, 1044, 10.1016/j.drudis.2012.05.010 Kang, 2015, Nanocarrier-mediated co-delivery of chemotherapeutic drugs and gene agents for cancer treatment, Acta Pharm Sin B, 5, 169, 10.1016/j.apsb.2015.03.001 Miao, 2017, Nanoformulations for combination or cascade anticancer therapy, Adv Drug Deliv Rev, 115, 3, 10.1016/j.addr.2017.06.003 Marupudi, 2007, Paclitaxel: a review of adverse toxicities and novel delivery strategies, Expert Opin Drug Saf, 6, 609, 10.1517/14740338.6.5.609 Tacar, 2012, Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems, J Pharm Pharmacol, 65, 157, 10.1111/j.2042-7158.2012.01567.x Kunnumakkara, 2008, Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins, Cancer Lett, 269, 199, 10.1016/j.canlet.2008.03.009 Dong, 2011, Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: a new paradigm for effective cancer therapy, Free Radical Biol Med, 50, 1546, 10.1016/j.freeradbiomed.2011.02.032 Fan, 1999, Possible mechanisms of paclitaxel-induced apoptosis, Biochem Pharmacol, 57, 1215 Wang, 2000, Paclitaxel-induced cell death: where the cell cycle and apoptosis come together, Cancer, 88, 2619, 10.1002/1097-0142(20000601)88:11<2619::AID-CNCR26>3.0.CO;2-J André, 2000, Paclitaxel induces release of cytochrome c from mitochondria isolated from human neuroblastoma cells, Cancer Res, 60, 5349 Barranco, 1973, Survival and cell kineticseffects of adriamycin on mammalian cells, Cancer Res, 33, 11 Ewa, 2004, The effect of doxorubicin and retinoids on proliferation, necrosis and apoptosis in MCF-7 breast cancer cells, Folia Histochem Cyto, 42, 221 Xu, 2017, Fabrication of a polypseudorotaxane nanoparticle with synergistic photodynamic and chemotherapy, Chin Chem Lett, 28, 1885, 10.1016/j.cclet.2017.07.029 Granados-Principal, 2014, Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer, Biochem Pharmacol, 90, 25, 10.1016/j.bcp.2014.04.001 D'Souza, 2011, Approaches for targeting mitochondria in cancer therapy, Biochim Biophys Acta, 1807, 689, 10.1016/j.bbabio.2010.08.008 Heller, 2012, Targeting drugs to mitochondria, Eur J Pharm Biopharm, 82, 1, 10.1016/j.ejpb.2012.05.014 Wenner, 2012, Targeting mitochondria as a therapeutic target in cancer, J Cell Physiol, 227, 450, 10.1002/jcp.22788 Ding, 2013, The performance of thiol-terminated PEG-paclitaxel-conjugated gold nanoparticles, Biomaterials, 34, 10217, 10.1016/j.biomaterials.2013.09.008 Liu, 2011, Tumor specific delivery and therapy by double-targeted nanostructured lipid carriers with anti-VEGFR-2 antibody, Mol Pharm, 8, 2291, 10.1021/mp200402e Bao, 2014, The enhanced longevity and liver targetability of paclitaxel by hybrid liposomes encapsulating paclitaxel-conjugated gold nanoparticles, Int J Pharm, 477, 408, 10.1016/j.ijpharm.2014.10.040 Wang, 2014, Amphiphilic carboxymethyl chitosan-quercetin conjugate with P-gp inhibitory properties for oral delivery of paclitaxel, Biomaterials, 35, 7654, 10.1016/j.biomaterials.2014.05.053 Lien, 2004, A substrate-phage approach for investigating caspase specificity, Protein J, 23, 413, 10.1023/B:JOPC.0000039555.92058.51 Jiang, 2015, Overcoming drug-resistant lung cancer by paclitaxel loaded dual-functional liposomes with mitochondria targeting and pH-response, Biomaterials, 52, 126, 10.1016/j.biomaterials.2015.02.004 Mu, 2014, Identification of biomarkers for hepatocellular carcinoma by semiquantitative immunocytochemistry, World J Gastroenterol, 20, 5826, 10.3748/wjg.v20.i19.5826 Seymour, 2002, Hepatic drug targeting: phase I evaluation of polymer-bound doxorubicin, J Clin Oncol, 20, 1668, 10.1200/JCO.20.6.1668 Gao, 2017, Intraorgan ttargeting of gold conjugates for precise liver cancer treatment, ACS Appl Mater Interfaces, 9, 31458, 10.1021/acsami.7b08969 Ding, 2014, Development of a liver-targeting gold-PEG-galactose nanoparticle platform and a structure-function study, Part Part Syst Char, 31, 347, 10.1002/ppsc.201300120 Hoye, 2008, Targeting mitochondria, Acc Chem Res, 41, 87, 10.1021/ar700135m Qu, 2015, Targeted delivery of doxorubicin to mitochondria using mesoporous silica nanoparticle nanocarriers, Nanoscale, 7, 16677, 10.1039/C5NR05139H Shchepinova, 2017, MitoNeoD: a mitochondria-targeted superoxide probe, Cell Chem Biol, 24, 1285, 10.1016/j.chembiol.2017.08.003 Zhang, 2015, Gold conjugate-based liposomes with hybrid cluster bomb structure for liver cancer therapy, Biomaterials, 74, 280, 10.1016/j.biomaterials.2015.10.004 Yang, 2019, Tumor microenvironment-responsive dual drug dimer-loaded pegylated bilirubin nanoparticles for improved drug delivery and enhanced immune-chemotherapy of breast cancer, Adv Funct Mater, 29, 1901896, 10.1002/adfm.201901896 Li, 2016, A review of the ligands and related targeting strategies for active targeting of paclitaxel to tumours, J Drug Target, 24, 590, 10.3109/1061186X.2016.1154561 Xu, 2014, Covalent functionalization of graphene oxide with biocompatible poly(ethylene glycol) for delivery of paclitaxel, ACS Appl Mater Interfaces, 6, 17268, 10.1021/am505308f Yardley, 2013, nab-Paclitaxel mechanisms of action and delivery, J Control Release, 170, 365, 10.1016/j.jconrel.2013.05.041 Thornberry, 1997, A combinatorial approach defines specificities of members of the caspase family and granzyme B: functional relationships established for key mediators of apoptosis, Biol Chem, 272, 17907, 10.1074/jbc.272.29.17907 Khosravi-Far, 2004, Death receptor signals to mitochondria, Cancer Biol Ther, 3, 1051, 10.4161/cbt.3.11.1173 Hou, 2018, Mitochondria: promising organelle targets for cancer diagnosis and treatment, Biomater Sci, 6, 2786, 10.1039/C8BM00673C Wang, 2015, Coumarin-modified gold nanoprobes for the sensitive detection of caspase-3, RSC Adv, 5, 43824, 10.1039/C5RA05350A Zhang, 2019, Screening of pH-responsive long-circulating polysaccharide–drug conjugate nanocarriers for antitumor applications, J Mater Chem B, 7, 251, 10.1039/C8TB02474J