Combination of the oral histone deacetylase inhibitor resminostat with oncolytic measles vaccine virus as a new option for epi-virotherapeutic treatment of hepatocellular carcinoma

Naik, 2009, Engineering oncolytic viruses to exploit tumor specific defects in innate immune signaling pathways, Expert Opin Biol Ther, 9, 1163, 10.1517/14712590903170653 Reikine, 2014, Pattern recognition and signaling mechanisms of RIG-I and MDA5, Front Immunol, 5, 342, 10.3389/fimmu.2014.00342 Akira, 2006, Pathogen recognition and innate immunity, Cell, 124, 783, 10.1016/j.cell.2006.02.015 Le Negrate, 2012, Viral interference with innate immunity by preventing NF-κB activity, Cell Microbiol, 14, 168, 10.1111/j.1462-5822.2011.01720.x Fensterl, 2011, The ISG56/IFIT1 gene family, J Interferon Cytokine Res, 31, 71, 10.1089/jir.2010.0101 Darnell, 1994, Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins, Science, 264, 1415, 10.1126/science.8197455 Diamond, 2013, The broad-spectrum antiviral functions of IFIT and IFITM proteins, Nat Rev Immunol, 13, 46, 10.1038/nri3344 Shingai, 2007, Differential type I IFN-inducing abilities of wild-type versus vaccine strains of measles virus, J Immunol, 179, 6123, 10.4049/jimmunol.179.9.6123 Naniche, 2000, Evasion of host defenses by measles virus: wild-type measles virus infection interferes with induction of Alpha/Beta interferon production, J Virol, 74, 7478, 10.1128/JVI.74.16.7478-7484.2000 Russell, 2012, Oncolytic virotherapy, Nat Biotechnol, 30, 658, 10.1038/nbt.2287 Berchtold, 2013, Innate immune defense defines susceptibility of sarcoma cells to measles vaccine virus-based oncolysis, J Virol, 87, 3484, 10.1128/JVI.02106-12 Preiss, 2008, Characterization of the innate immune signalling pathways in hepatocyte cell lines, J Viral Hepat, 15, 888, 10.1111/j.1365-2893.2008.01001.x Nguyen, 2010, Oncolytic viruses and histone deacetylase inhibitors–a multi-pronged strategy to target tumor cells, Cytokine Growth Factor Rev, 21, 153, 10.1016/j.cytogfr.2010.03.002 Nguyên, 2008, Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis, Proc Natl Acad Sci USA, 105, 14981, 10.1073/pnas.0803988105 Bridle, 2013, HDAC inhibition suppresses primary immune responses, enhances secondary immune responses, and abrogates autoimmunity during tumor immunotherapy, Mol Ther, 21, 887, 10.1038/mt.2012.265 Noyce, 2011, Tumor cell marker PVRL4 (nectin 4) is an epithelial cell receptor for measles virus, PLoS Pathog, 7, e1002240, 10.1371/journal.ppat.1002240 MacTavish, 2010, Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors, PLoS One, 5, e14462, 10.1371/journal.pone.0014462 Otsuki, 2008, Histone deacetylase inhibitors augment antitumor efficacy of herpes-based oncolytic viruses, Mol Ther, 16, 1546, 10.1038/mt.2008.155 Alvarez-Breckenridge, 2012, The histone deacetylase inhibitor valproic acid lessens NK cell action against oncolytic virus-infected glioblastoma cells by inhibition of STAT5/T-BET signaling and generation of gamma interferon, J Virol, 86, 4566, 10.1128/JVI.05545-11 Cody, 2014, Histone deacetylase inhibitors improve the replication of oncolytic herpes simplex virus in breast cancer cells, PLoS One, 9, e92919, 10.1371/journal.pone.0092919 Liu, 2008, Trichostatin A and oncolytic HSV combination therapy shows enhanced antitumoral and antiangiogenic effects, Mol Ther, 16, 1041, 10.1038/mt.2008.58 Li, 2013, Synergistic combination of valproic acid and oncolytic parvovirus H-1PV as a potential therapy against cervical and pancreatic carcinomas, EMBO Mol Med, 5, 1537, 10.1002/emmm.201302796 Kitazono, 2001, Enhanced adenovirus transgene expression in malignant cells treated with the histone deacetylase inhibitor FR901228, Cancer Res, 61, 6328 Höti, 2006, Valproic acid, a histone deacetylase inhibitor, is an antagonist for oncolytic adenoviral gene therapy, Mol Ther, 14, 768, 10.1016/j.ymthe.2006.07.009 Mandl-Weber, 2010, The novel inhibitor of histone deacetylase resminostat (RAS2410) inhibits proliferation and induces apoptosis in multiple myeloma (MM) cells, Br J Haematol, 149, 518, 10.1111/j.1365-2141.2010.08124.x Bitzer, 2013, Resminostat in advanced hepatocellular carcinoma (HCC): overall survival subgroup analysis of prognostic factors in the SHELTER trial, ASCO Meeting Abstracts, 31, e15088 Noll, 2013, Primary resistance phenomena to oncolytic measles vaccine viruses, Int J Oncol, 43, 103, 10.3892/ijo.2013.1914 Lampe, 2013, An armed oncolytic measles vaccine virus eliminates human hepatoma cells independently of apoptosis, Gene Ther, 20, 1033, 10.1038/gt.2013.28 Lange, 2013, A novel armed oncolytic measles vaccine virus for the treatment of cholangiocarcinoma, Hum Gene Ther, 24, 554, 10.1089/hum.2012.136 Völker, 2013, Intrahepatic application of suicide gene-armed measles virotherapeutics: a safety study in transgenic mice and rhesus macaques, Hum Gene Ther Clin Dev, 24, 11, 10.1089/humc.2012.242 Russell, 2014, Remission of disseminated cancer after systemic oncolytic virotherapy, Mayo Clin Proc, 89, 926, 10.1016/j.mayocp.2014.04.003 Galanis, 2015, Oncolytic measles virus expressing the sodium iodide symporter to treat drug-resistant ovarian cancer, Cancer Res, 75, 22, 10.1158/0008-5472.CAN-14-2533 Galanis, 2010, Phase I trial of intraperitoneal administration of an oncolytic measles virus strain engineered to express carcinoembryonic antigen for recurrent ovarian cancer, Cancer Res, 70, 875, 10.1158/0008-5472.CAN-09-2762 Yurttas, 2014, Pulsed versus continuous application of the prodrug 5-fluorocytosine to enhance the oncolytic effectiveness of a measles vaccine virus armed with a suicide gene, Hum Gene Ther Clin Dev, 25, 85, 10.1089/humc.2013.127 Katsura, 2009, The effects of trichostatin A on the oncolytic ability of herpes simplex virus for oral squamous cell carcinoma cells, Cancer Gene Ther, 16, 237, 10.1038/cgt.2008.81 Shulak, 2014, Histone deacetylase inhibitors potentiate vesicular stomatitis virus oncolysis in prostate cancer cells by modulating NF-κB-dependent autophagy, J Virol, 88, 2927, 10.1128/JVI.03406-13 Kim, 2012, Combination therapy of conditionally replicating adenovirus and histone deacetylase inhibitors, Int J Mol Med, 29, 218 Delpeut, 2012, Host factors and measles virus replication, Curr Opin Virol, 2, 773, 10.1016/j.coviro.2012.10.008 Bressac, 1990, Abnormal structure and expression of p53 gene in human hepatocellular carcinoma, Proc Natl Acad Sci USA, 87, 1973, 10.1073/pnas.87.5.1973 Dunn, 2006, Interferons, immunity and cancer immunoediting, Nat Rev Immunol, 6, 836, 10.1038/nri1961 Stojdl, 2003, VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents, Cancer Cell, 4, 263, 10.1016/S1535-6108(03)00241-1 Stewart, 2014, Inhibitors of the interferon response enhance virus replication in vitro, PLoS One, 9, e112014, 10.1371/journal.pone.0112014 Forbes, 2013, Exploiting tumor epigenetics to improve oncolytic virotherapy, Front Genet, 4, 184, 10.3389/fgene.2013.00184 Nusinzon, 2006, Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation, Mol Cell Biol, 26, 3106, 10.1128/MCB.26.8.3106-3113.2006 Chang, 2004, Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity, Proc Natl Acad Sci USA, 101, 9578, 10.1073/pnas.0400567101 Nusinzon, 2003, Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1, Proc Natl Acad Sci USA, 100, 14742, 10.1073/pnas.2433987100 Pichlmair, 2011, IFIT1 is an antiviral protein that recognizes 5’-triphosphate RNA, Nat Immunol, 12, 624, 10.1038/ni.2048 Mogensen, 2009, Pathogen recognition and inflammatory signaling in innate immune defenses, Clin Microbiol Rev, 22, 240, 10.1128/CMR.00046-08 Wang, 2013, Zinc finger protein 64 promotes Toll-like receptor-triggered proinflammatory and type I interferon production in macrophages by enhancing p65 subunit activation, J Biol Chem, 288, 24600, 10.1074/jbc.M113.473397 Graepler, 2005, Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model, World J Gastroenterol, 11, 6910, 10.3748/wjg.v11.i44.6910 Spearman, 1908, The method of ‘right and wrong cases’ (‘constant stimuli’) without Gauss's formulae, British Journal of Psychology 1904-1920, 2, 227, 10.1111/j.2044-8295.1908.tb00176.x Kärber, 1931, Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche, Archiv f experiment Pathol u Pharmakol, 162, 480, 10.1007/BF01863914 Skehan, 1990, New colorimetric cytotoxicity assay for anticancer-drug screening, J Natl Cancer Inst, 82, 1107, 10.1093/jnci/82.13.1107 Nicoletti, 1991, A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry, J Immunol Methods, 139, 271, 10.1016/0022-1759(91)90198-O