Combination chemotherapy: The interaction of methotrexate and 5-fluorouracil

European Journal of Cancer (1965) - Tập 9 Số 10 - Trang 733-739 - 1973
Martin H. N. Tattersall1, Robert Jackson1, T. A. Connors1, K. R. Harrap1
1Department of Applied Biochemistry, Chester Beatty Research Institute Institute of Cancer Research: Royal Cancer Hospital, Fulham Road, London SW3 6JB, England

Tóm tắt

Từ khóa


Tài liệu tham khảo

Constanzi, 1969, Combination chemotherapy using cyclophosphamide, vincristine, methotrexate and 5-fluorouracil in solid tumours, Cancer, 23, 589, 10.1002/1097-0142(196903)23:3<589::AID-CNCR2820230310>3.0.CO;2-A

Dorsk, 1972, Combination chemotherapy with five drugs in advanced metastatic breast cancer, 30

Price, 1971, Multiple drug therapy for disseminated malignant tumours, Brit. Med. J., 4, 336, 10.1136/bmj.4.5783.336

Sartorelli, 1969, Some approaches to the therapeutic exploitation of metabolic sites of vulnerability of neoplastic cells, Cancer Res., 29, 2292

Jackson, 1973, Studies with a mathematical model of folate metabolism, Arch Biochem. Biophys., 10.1016/0003-9861(73)90579-1

Dunlap, 1971, Thymidylate synthetase from amethopterin-resistant, Lactobacillus casei. Biochemistry, 10, 88, 10.1021/bi00777a014

Harrap, 1971, Sites of action of methotrexate: intrinsic and acquired drug resistance, Ann. N.Y. Acad. Sci., 186, 312, 10.1111/j.1749-6632.1971.tb46986.x

Elion, 1954, Antagonists of nucleic acid derivatives VIII Synergism in combinations of biochemically related antimetabolites, J. biol. Chem., 208, 477, 10.1016/S0021-9258(18)65573-5

Futtermann, 1957, The inactivation of folic acid by liver, J. biol. Chem., 224, 31, 10.1016/S0021-9258(18)65007-0

Osborn, 1958, Inhibition of dihydrofolic reductase by aminoprotein and amethopterin, 97, 429

Hartmann, 1961, Studies on fluorinated pyrimidines. XIII Inhibition of thymidylate synthetase, J. biol. Chem., 236, 3006, 10.1016/S0021-9258(19)76419-9

Vitale, 1956, Effects of aminopterin administration on the metabolism of liver and small intestine of guinea pigs and rats, J. biol. Chem., 220, 363, 10.1016/S0021-9258(18)65361-X

Henderson, 1972, Evidence that drugs in multiple combinations have materially advanced the treatment of human malignancies, Cancer Res., 29, 2272

Carbone, 1968, Management of patients with malignant lymphoma: a comparative study with cyclophosphamide and vinca alkaloids, Cancer Res., 25, 811

Tattersall, 1972, The interaction of methotrexate and cytosine arabinoside, Lancet, ii, 1378, 10.1016/S0140-6736(72)92835-8

Grindey, 1972, Interaction of drugs inhibiting different steps on the synthesis of DNA, Cancer Res., 32, 527

Reyes, 1965, Fluorinated pyrimidines: XXVI Mammalian thymidylate synthetase; its mechanism of action and inhibition by fluorinated nucleotides, Molec. Pharmacol., 1, 14

Strauss, 1943, Zone behaviour of enzymes, J. gen. Physiol., 26, 559, 10.1085/jgp.26.6.559

Tattersall, 1973, Combination chemotherapy: the antagonism of methotrexate and cytosine arabinoside, Europ. J. Cancer, 9, 229, 10.1016/S0014-2964(73)80023-4