Coherence and Timing of Cell Cycle Start Examined at Single-Cell Resolution

Amon, 1994, Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle, Cell, 77, 1037, 10.1016/0092-8674(94)90443-X Bean, 2005, High functional overlap between MluI cell-cycle box binding factor and Swi4/6 cell-cycle box binding factor in the G1/S transcriptional program in Saccharomyces cerevisiae, Genetics, 171, 49, 10.1534/genetics.105.044560 Becskei, 2005, Contributions of low molecule number and chromosomal positioning to stochastic gene expression, Nat. Genet., 37, 937, 10.1038/ng1616 Cosma, 1999, Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle- and developmentally regulated promoter, Cell, 97, 299, 10.1016/S0092-8674(00)80740-0 Cosma, 2001, Cdk1 triggers association of RNA polymerase to cell cycle promoters only after recruitment of the mediator by SBF, Mol. Cell, 7, 1213, 10.1016/S1097-2765(01)00266-0 Costanzo, 2004, CDK activity antagonizes Whi5, an inhibitor of G1/S transcription in yeast, Cell, 117, 899, 10.1016/j.cell.2004.05.024 Cross, 1988, DAF1, a mutant gene affecting size control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiae, Mol. Cell. Biol., 8, 4675, 10.1128/MCB.8.11.4675 Cross, 1995, Starting the cell cycle: what's the point?, Curr. Opin. Cell Biol., 7, 790, 10.1016/0955-0674(95)80062-X Cross, 2003, Two redundant oscillatory mechanisms in the yeast cell cycle, Dev. Cell, 4, 741, 10.1016/S1534-5807(03)00119-9 Cross, 1991, A potential positive feedback loop controlling CLN1 and CLN2 gene expression at the start of the yeast cell cycle, Cell, 65, 875, 10.1016/0092-8674(91)90394-E Cross, 1994, Role of Swi4 in cell cycle regulation of CLN2 expression, Mol. Cell. Biol., 14, 4779, 10.1128/MCB.14.7.4779 Cross, 2005, Quantitative characterization of a mitotic cyclin threshold regulating exit from mitosis, Mol. Biol. Cell, 16, 2129, 10.1091/mbc.E04-10-0897 de Bruin, 2004, Cln3 activates G1-specific transcription via phosphorylation of the SBF bound repressor Whi5, Cell, 117, 887, 10.1016/j.cell.2004.05.025 Di Como, 1995, Activation of CLN1 and CLN2 G1 cyclin gene expression by BCK2, Mol. Cell. Biol., 15, 1835, 10.1128/MCB.15.4.1835 Dirick, 1991, Positive feedback in the activation of G1 cyclins in yeast, Nature, 351, 754, 10.1038/351754a0 Dirick, 1995, Roles and regulation of Cln-Cdc28 kinases at the start of the cell cycle of Saccharomyces cerevisiae, EMBO J., 14, 4803, 10.1002/j.1460-2075.1995.tb00162.x Elowitz, 2002, Stochastic gene expression in a single cell, Science, 297, 1183, 10.1126/science.1070919 Epstein, 1994, Genes that can bypass the CLN requirement for Saccharomyces cerevisiae cell cycle START, Mol. Cell. Biol., 14, 2041, 10.1128/MCB.14.3.2041 Hartwell, 1977, Unequal division in Saccharomyces cerevisiae and its implications for the control of cell division, J. Cell Biol., 75, 422, 10.1083/jcb.75.2.422 Igual, 1996, Coordinated regulation of gene expression by the cell cycle transcription factor Swi4 and the protein kinase C MAP kinase pathway for yeast cell integrity, EMBO J., 15, 5001, 10.1002/j.1460-2075.1996.tb00880.x Jacquet, 2003, Oscillatory nucleocytoplasmic shuttling of the general stress response transcriptional activators Msn2 and Msn4 in Saccharomyces cerevisiae, J. Cell Biol., 161, 497, 10.1083/jcb.200303030 Johnston, 1977, Coordination of growth with cell division in the yeast Saccharomyces cerevisiae, Exp. Cell Res., 105, 79, 10.1016/0014-4827(77)90154-9 Jorgensen, 2004, How cells coordinate growth and division, Curr. Biol., 14, R1014, 10.1016/j.cub.2004.11.027 Jorgensen, 2002, Systematic identification of pathways that couple cell growth and division in yeast, Science, 297, 395, 10.1126/science.1070850 Kato, 2004, Identifying combinatorial regulation of transcription factors and binding motifs, Genome Biol., 5, R56, 10.1186/gb-2004-5-8-r56 Koch, 1994, Cell cycle regulated transcription in yeast, Curr. Opin. Cell Biol., 6, 451, 10.1016/0955-0674(94)90039-6 Koch, 1993, A role for the transcription factors Mbp1 and Swi4 in progression from G1 to S phase, Science, 261, 1551, 10.1126/science.8372350 Koch, 1996, Switching transcription on and off during the yeast cell cycle: Cln/Cdc28 kinases activate bound transcription factor SBF (Swi4/Swi6) at start, whereas Clb/Cdc28 kinases displace it from the promoter in G2, Genes Dev., 10, 129, 10.1101/gad.10.2.129 Kron, 1994, Symmetric cell division in pseudohyphae of the yeast Saccharomyces cerevisiae, Mol. Biol. Cell, 5, 1003, 10.1091/mbc.5.9.1003 Laabs, 2003, ACE2 is required for daughter cell-specific G1 delay in Saccharomyces cerevisiae, Proc. Natl. Acad. Sci. USA, 100, 10275, 10.1073/pnas.1833999100 Lord, 1980, Asymmetrical division of Saccharomyces cerevisiae, J. Bacteriol., 142, 808, 10.1128/JB.142.3.808-818.1980 Lord, 1981, Variability in individual cell cycles of Saccharomyces cerevisiae, J. Cell Sci., 50, 361, 10.1242/jcs.50.1.361 Lord, 1983, Rate of cell cycle initiation of yeast cells when cell size is not a rate-determining factor, J. Cell Sci., 59, 183, 10.1242/jcs.59.1.183 MacKay, 2001, Early cell cycle box-mediated transcription of CLN3 and SWI4 contributes to the proper timing of the G(1)-to-S transition in budding yeast, Mol. Cell. Biol., 21, 4140, 10.1128/MCB.21.13.4140-4148.2001 Mateus, 2000, Destabilized green fluorescent protein for monitoring dynamic changes in yeast gene expression with flow cytometry, Yeast, 16, 1313, 10.1002/1097-0061(200010)16:14<1313::AID-YEA626>3.0.CO;2-O Moffat, 2004, Late-G1 cyclin-CDK activity is essential for control of cell morphogenesis in budding yeast, Nat. Cell Biol., 6, 59, 10.1038/ncb1078 Nash, 1988, The WHI1+ gene of Saccharomyces cerevisiae tethers cell division to cell size and is a cyclin homolog, EMBO J., 7, 4335, 10.1002/j.1460-2075.1988.tb03332.x Nasmyth, 1996, At the heart of the budding yeast cell cycle, Trends Genet., 12, 405, 10.1016/0168-9525(96)10041-X Newport, 1984, Regulation of the cell cycle during early Xenopus development, Cell, 37, 731, 10.1016/0092-8674(84)90409-4 Ozbudak, 2002, Regulation of noise in the expression of a single gene, Nat. Genet., 31, 69, 10.1038/ng869 Park, 2003, Loss of CDC5 function in Saccharomyces cerevisiae leads to defects in Swe1p regulation and Bfa1p/Bub2p-independent cytokinesis, Genetics, 163, 21, 10.1093/genetics/163.1.21 Raser, 2004, Control of stochasticity in eukaryotic gene expression, Science, 304, 1811, 10.1126/science.1098641 Rosenfeld, 2005, Gene regulation at the single-cell level, Science, 307, 1962, 10.1126/science.1106914 Schneider, 2004, Growth rate and cell size modulate the synthesis of, and requirement for, G1-phase cyclins at start, Mol. Cell. Biol., 24, 10802, 10.1128/MCB.24.24.10802-10813.2004 Spellman, 1998, Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization, Mol. Biol. Cell, 9, 3273, 10.1091/mbc.9.12.3273 Stewart, 2005, Aging and death in an organism that reproduces by morphologically symmetric division, PLoS Biol., 3, e45, 10.1371/journal.pbio.0030045 Stuart, 1994, Cell cycle-dependent transcription of CLN2 is conferred by multiple distinct cis-acting regulatory elements, Mol. Cell. Biol., 14, 4788, 10.1128/MCB.14.7.4788 Stuart, 1995, CLN3, not positive feedback, determines the timing of CLN2 transcription in cycling cells, Genes Dev., 9, 2780, 10.1101/gad.9.22.2780 Sveiczer, 2001, A stochastic, molecular model of the fission yeast cell cycle: role of the nucleocytoplasmic ratio in cycle time regulation, Biophys. Chem., 92, 1, 10.1016/S0301-4622(01)00183-1 Swain, 2002, Intrinsic and extrinsic contributions to stochasticity in gene expression, Proc. Natl. Acad. Sci. USA, 99, 12795, 10.1073/pnas.162041399 Toone, 1995, Rme1, a negative regulator of meiosis, is also a positive activator of G1 cyclin gene expression, EMBO J., 14, 5824, 10.1002/j.1460-2075.1995.tb00270.x Tyers, 1993, Comparison of the Saccharomyces cerevisiae G1 cyclins: Cln3 may be an upstream activator of Cln1, Cln2 and other cyclins, EMBO J., 12, 1955, 10.1002/j.1460-2075.1993.tb05845.x Wijnen, 2002, The G(1) cyclin Cln3 promotes cell cycle entry via the transcription factor Swi6, Mol. Cell. Biol., 22, 4402, 10.1128/MCB.22.12.4402-4418.2002 Xie, 2004, Learning in neural networks by reinforcement of irregular spiking, Phys. Rev. E Stat. Nonlin. Soft Matter Phys., 69, 041909, 10.1103/PhysRevE.69.041909