Cognitive Impairments in Patients with Multiple Sclerosis: Correlations Between Neuropsychological, Neurophysiological, and Neuroimaging Parameters

The aim of this study was to assess the neuropsychological status of patients and their P300 cognitive evoked potentials and to attempt to evaluate the clinical significance of cerebral atrophy in multiple sclerosis (MS). Neuropsychological studies were performed in 109 patients with MS. Cognitive functions were evaluated using the mini-mental state examination (MMSE), the frontal assessment battery (FAB), the A. R. Luriya method, and P300 cognitive evoked potentials; MRI data from 71 patients were also analyzed. The results obtained from these studies led to the conclusion that changes in status and cognitive function, disease activity, and the severity of cerebral atrophy are correlated.