Cognitive Executive Dysfunction in Children with Mild Sleep-Disordered Breathing

Biological Research for Nursing - Tập 5 Số 3 - Trang 168-176 - 2004
Kristen Hedger Archbold1, Bruno Giordani2, Deborah L. Ruzicka3, Ronald D. Chervin3
1Biobehavioral Nursing and Health Systems at the University of Washington School of Nursing, Seattle
2Division of Neuropsychology, Department of Psychiatry, at the University of Michigan, Ann Arbor
3Aldrich Sleep Disorders Center, Department of Neurology, at the University of Michigan, Ann Arbor

Tóm tắt

In children, moderate or severe sleep-disordered breathing (SDB) may impair cognitive executive functions (EFs), including working memory, attention, and mental flexibility. The main objective of this study was to assess EFs in children with mild levels of SDB. Subjects for this descriptive study were 12 children (5 girls, 7 boys) aged 8.0 to 11.9 years (M = 9.0 ± 0.85) participating in an ongoing study of the effects of adenotonsillectomy on behavior. Each subject had a nocturnal polysomnogram (PSG) and multiple sleep latency test (MSLT). Mild SDB was considered present if the child’s apnea/hypopnea index (AHI) was ≥ 1 and < 10. Between MSLT nap attempts, each child completed standardized tests of EFs. The sample showed significant impairment of sustained attention and vigilance on a computerized continuous performance test. Children with low mental flexibility scores on the Children’s Category Test (CCT) spent more time in stage 1 sleep (12.2% v. 9.5%, P = 0.028 on PSG) and showed a marginally higher arousal index (9.7 v. 6.5, P = 0.06 on PSG) than children with average or above-average CCT scores. AHI accounted for significant proportion of the variance in CCT scores when 1 outlier was removed (N = 11, Rsq = 0.67, P = 0.002). Mild levels of SDB and associated sleep architecture disruptions may be associated with impairment of EFs in children.

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Tài liệu tham khảo

Ali NJ, Pitson D, Stradling JR. 1996. Sleep disordered breathing: effects of adenotonsillectomy on behaviour and psychological functioning. Eur J Pediatr 155:56-62.

10.1164/ajrccm.153.1.8542162

American Academy of Sleep Medicine. 2000. International classification of sleep disorders, revised: diagnostic and coding manual. Rochester (MN): American Academy of Sleep Medicine.

10.1067/mpd.2002.119990

Barkley RA, Fisher M, Edelbrook CS, Smallish L. 1990. The adolescent outcome of hyperactive children diagnosed by research criteria: an 8-year prospective follow-up study. J Am Acad Child Adolesc Psychiatry 29:557.

Boll T. 1993. Children’s Category Test: manual. San Antonio (TX): Harcourt Brace.

10.1016/S0030-6665(05)70207-3

Burns N, Grove SK. 1993. The practice of nursing research: conduct, critique & utilization. Philadelphia: W.B. Saunders.

Carskadon MA, Keenan S, Dement WC. 1987. Nighttime sleep and daytime sleep tendency in preadolescents. In: Guilleminault C, editor. Sleep and its disorders in children. New York: Raven. p 43-52.

Caspi A, Moffit TE, Newman DL, Silva PA. 1996. Behavioral observations at age 3 years predict adult psychiatric disorders. Arch Gen Psychiatry 53:1039.

10.1542/peds.107.6.1375

Cohen MJ. 1997. Children’s Memory Scale. San Antonio (TX): Psychological Corporation.

10.1016/S1071-9091(96)80028-3

10.1017/S0021963097001753

10.1164/ajrccm.162.2.9908058

10.1093/sleep/24.8.937

10.1542/peds.102.3.616

10.1093/sleep/10.3.254

10.1207/s15374424jccp2603_9

10.1097/00004583-199105000-00005

10.1016/S1389-9457(01)00070-3

Lezak M. 1995. Neuropsychological assessment. New York: Oxford University Press.

Lorino AM, Lorino H, Dahan E, d’Ortho MP, Coste A, Harf A, Lofaso F. 2000. Effects of nasal prongs on nasal airflow resistance. Chest 1189:366-371.

10.1016/S0028-3932(97)00109-7

10.1097/00004703-199806000-00005

Marcus CL, Carroll JL. 1993. Obstructive sleep apnea syndrome. In: Loughlin GM, Eigen H, editors. Respiratory disease in children: diagnosis and management. Baltimore: Williams and Wilkins. p 475-499.

10.1016/S1071-9091(96)80025-8

Nada-Raja S, Langley JD, McGee R, Williams SM, Begg DJ, Reeder AI. 1997. Inattentive and hyperactive behaviors and driving offences in adolescence. J Am Acad Child Adolesc Psychiatry 35:522.

Norman RG, Ahmed MM, Walsleben JA, Rapoport DM. 1997. Detection of respiratory events during NPSG: nasal cannula/ pressure sensor versus thermistor. Sleep 20:1175-1184.

10.1097/00004703-200002000-00005

10.1111/1469-8986.3650571

Psychological Corporation. 1992. Weschler Individual Achievement Test: manual. San Antonio (TX): Harcourt Brace.

Psychological Corporation. 1999. Weschler Abbreviated Scale of Intelligence: manual. San Antonio (TX): Harcourt Brace.

Randazzo AC, Muehlbach MJ, Schweitzer PK, Walsh JK. 1998. Cognitive function following acute sleep restriction in children ages 10-14. Sleep 15:861-868.

10.1016/S0022-3476(95)70164-8

Riopel LV, Forest G, Lussier I, Stip E, Godbout R. 1997. Performance on a selective attention task correlates with sleep organization in normal young subjects. Sleep Res 26:211.

10.1037/0012-1649.36.3.291

Sandford JA, Turner A. 1995. Manual for the intermediate visual and auditory continuous performance test. Richmond (VA): Brain Train.

10.1002/ppul.10096

10.1016/0166-4328(95)00024-N

Smith C, MacNeill C. 1992. Memory for motor task is impaired by stage 2 sleep loss. Sleep Res 21:139.

10.1097/00004583-200301000-00014

10.1164/rccm.2110114

10.1097/00004691-199605000-00003

10.1046/j.1440-1819.2000.00700.x

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Biological Research for Nursing

Tập 5 Số 3

168-176

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