Cognitive-Emotional Signs of Aging in F1 Mice (C57BL/6 × DBA/2)

Advances in Gerontology - 2021
K. A. Nikolskaya1, M. V. Kondashevskaya2
1Moscow State University, Moscow, Russia
2Research Institute of Human Morphology, Moscow, Russia

Tóm tắt

Cognitive-emotional signs of aging were studied in F1 (C57BL/6 × DBA/2) mice at the ages of 3, 7, and 14 months. It was found that memory-trace fixation, the first appearance of the minimized variant of the solution of the problem (the minimized route, MR), and the rate of its subsequent retrieval in the experiment, as well as the breadth of the emotional repertoire in all animals, did not depend on age. The greatest age-related differences were associated with the ability of mice to reproduce MR sustainably. It turned out that such an implementation was possible only if it was preceded by a period of mistakes. Moreover, the older the animal was, the higher was the number of unsuccessful attempts and levels of provoked stressful and neurotic reactions required for food acquisition. The data indicates that the activating effects of negative emotional arousal are a mechanism that contributes to the achievement of the level of excitation required for the realization of the dominant state upon a weak energy state of the central nervous system.

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