Coenzyme Q10 supplementation of human oocyte in vitro maturation reduces postmeiotic aneuploidies

Huang, 2008, Maternal age and risk of stillbirth: a systematic review, CMAJ, 178, 165, 10.1503/cmaj.070150 O’Connor, 1998, Declining fecundity and ovarian ageing in natural fertility populations, Maturitas, 30, 127, 10.1016/S0378-5122(98)00068-1 Demko, 2016, Effects of maternal age on euploidy rates in a large cohort of embryos analyzed with 24-chromosome single-nucleotide polymorphism-based preimplantation genetic screening, Fertil Steril, 105, 1307, 10.1016/j.fertnstert.2016.01.025 Nagaoka, 2012, Human aneuploidy: mechanisms and new insights into an age-old problem, Nat Rev Genet, 13, 493, 10.1038/nrg3245 Bentov, 2013, The aging oocyte-can mitochondrial function be improved?, Fertil Steril, 99, 18, 10.1016/j.fertnstert.2012.11.031 Wai, 2010, The role of mitochondrial DNA copy number in mammalian fertility, Biol Reprod, 83, 52, 10.1095/biolreprod.109.080887 Santos, 2006, Mitochondrial content reflects oocyte variability and fertilization outcome, Fertil Steril, 85, 584, 10.1016/j.fertnstert.2005.09.017 May-Panloup, 2005, Low oocyte mitochondrial DNA content in ovarian insufficiency, Hum Reprod, 20, 593, 10.1093/humrep/deh667 Yu, 2010, Redistribution of mitochondria leads to bursts of ATP production during spontaneous mouse oocyte maturation, J Cell Physiol, 224, 672, 10.1002/jcp.22171 Dalton, 2014, Measurement of ATP in single oocytes: impact of maturation and cumulus cells on levels and consumption, J Cell Physiol, 229, 353, 10.1002/jcp.24457 Eichenlaub-Ritter, 2011, Age related changes in mitochondrial function and new approaches to study redox regulation in mammalian oocytes in response to age or maturation conditions, Mitochondrion, 11, 783, 10.1016/j.mito.2010.08.011 Dumollard, 2004, Sperm-triggered [Ca2+] oscillations and Ca2+ homeostasis in the mouse egg have an absolute requirement for mitochondrial ATP production, Develop, 131, 3057, 10.1242/dev.01181 Van Blerkom, 2011, Mitochondrial function in the human oocyte and embryo and their role in developmental competence, Mitochondrion, 11, 797, 10.1016/j.mito.2010.09.012 Bentov, 2010, The use of mitochondrial nutrients to improve the outcome of infertility treatment in older patients, Fertil Steril, 93, 272, 10.1016/j.fertnstert.2009.07.988 Bentinger, 2007, The antioxidant role of coenzyme Q, Mitochondrion, 7, S41, 10.1016/j.mito.2007.02.006 Kalen, 1989, Age-related changes in the lipid compositions of rat and human tissues, Lipids, 24, 579, 10.1007/BF02535072 Miles, 2004, Age-related changes in plasma coenzyme Q10 concentrations and redox state in apparently healthy children and adults, Clin Chim Acta, 347, 139, 10.1016/j.cccn.2004.04.003 Ben-Meir, 2015, Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging, Aging Cell, 14, 887, 10.1111/acel.12368 Bentov, 2014, Coenzyme Q10 supplementation and oocyte aneuploidy in women undergoing IVF-ICSI treatment, Clin Med Insights Reprod Health, 8, 31, 10.4137/CMRH.S14681 Fiorentino, 2014, Development and validation of a next-generation sequencing-based protocol for 24-chromosome aneuploidy screening of embryos, Fertil Steril, 101, 1375, 10.1016/j.fertnstert.2014.01.051 Wang, 2017, referential selection and transfer of euploid noncarrier embryos in preimplantation genetic diagnosis cycles for reciprocal translocations, Fertil Steril, 108, 620, 10.1016/j.fertnstert.2017.07.010 Brunet, 2018, Preimplantation genetic testing for complex chromosomal rearrangement carriers by next-generation sequencing, Reprod Biomed Online, 37, 375, 10.1016/j.rbmo.2018.07.001 Fragouli, 2013, The origin and impact of embryonic aneuploidy, Hum Genet, 132, 1001, 10.1007/s00439-013-1309-0 Tao, 2013, Deficiency of ovarian ornithine decarboxylase contributes to aging-related egg aneuploidy in mice, Aging Cell, 12, 42, 10.1111/acel.12016 Kuliev, 2011, Meiosis errors in over 20,000 oocytes studied in the practice of preimplantation aneuploidy testing, Reprod Biomed Online, 22, 2, 10.1016/j.rbmo.2010.08.014 Angell, 1991, Predivision in human oocytes at meiosis I: a mechanism for trisomy formation in man, Hum Genet, 86, 383, 10.1007/BF00201839 Angell, 1997, First-meiotic-division nondisjunction in human oocytes, Am J Hum Genet, 61, 23, 10.1086/513890 Angell, 1994, First meiotic division abnormalities in human oocytes: mechanism of trisomy formation, Cytogenet Cell Genet, 65, 194, 10.1159/000133631 Mehta, 2014, Sources of DNA double-strand breaks and models of recombinational DNA repair, Cold Spring Harb Perspect Biol, 6, a016428, 10.1101/cshperspect.a016428 Babariya, 2017, The incidence and origin of segmental aneuploidy in human oocytes and preimplantation embryos, Hum Reprod, 32, 2549, 10.1093/humrep/dex324 Xu, 2018, Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial, Reprod Biol Endocrinol, 16, 29, 10.1186/s12958-018-0343-0 El Refaeey, 2014, Combined coenzyme Q10 and clomiphene citrate for ovulation induction in clomiphene-citrate-resistant polycystic ovary syndrome, Reprod BioMed Online, 29, 119, 10.1016/j.rbmo.2014.03.011 Ben-Meir, 2015, Coenzyme Q-dependent mitochondrial respiratory chain activity in granulosa cells is reduced with aging, Fertil Steril, 104, 724, 10.1016/j.fertnstert.2015.05.023 Perkins, 2016, Oxidative stress in oocytes during midprophase induces premature loss of cohesion and chromosome segregation errors, Proc Natl Acad Sci U S A, 113, E6823, 10.1073/pnas.1612047113