Coats' Disease: A Study of 62 Histologically Confirmed Cases

Journal of Pediatric Ophthalmology and Strabismus - Tập 21 Số 5 - Trang 163-168 - 1984
Meimei Chang, Ian W. McLean, J C Merritt

Tóm tắt

SUMMARY We studied 62 eyes submitted to the Armed Forces Institute of Pathology (AFIP) from 1958 through 1980 that satisfied our criteria for the histologie diagnosis of Coats' disease. Our histopathologic definition of Coats'disease was the presence of a primary vascular lesion consisting of retinal telangiectasia with leakage of plasma toform intraretinal and subretinal exuda t es. In the cases we reviewed, Coats' disease occurred more frequently in boys, it usually affectedonly one eye, and wasgenerally detected in the first decade of life. In 52 cases (79%) theclinical manifestations, strabismus and leukokoria, were thought to be caused by retinoblastoma. Angle closure glaucoma was present in 36 cases (58%). In all but one of the cases studied, the lesion waslocated peripheral to theequator. We further identified diffuse involvement of capillaries in the peripheral retina using trypsin-digest preparations. Associated histologie findings included: rubeosis iridis, cataract, vitreous neovascular ization, and nodules resulting from fibrous metaplasia of the retinal pigment epithelium. These fibrous nodules typically occurred in the macular area and occasionally contained calcium or bone.

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Tài liệu tham khảo

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Thông tin xuất bản

Journal of Pediatric Ophthalmology and Strabismus

Tập 21 Số 5

163-168

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