Clinical studies in head and neck cancer chemoprevention

Cancer and Metastasis Reviews - Tập 15 - Trang 113-118 - 1996
Pablo M. Gonzalez1, Steven E. Benner1
1Division of Hematology/Oncology, University of North Carolina at Chapel Hill, USA

Tóm tắt

Secondary neoplasms represent a major threat for patients with head and neck cancer. The prevention of secondary neoplasms has been a major goal of head and neck cancer chemoprevention efforts. In order to help develop effective strategies, reversal of oral premalignancy has been used as a model for chemoprevention. There is now sufficient data to show the chemopreventive effect in premalignant lesions of some natural compounds and their derivatives. Retinoids are the most studied chemopreventive agents for the treatment of oral leukoplakia. Other compounds with chemopreventive activity are carotenoids, Vitamin E derivatives and Selenium. There are two large prospective, randomized, chemoprevention clinical trials, one in Europe and the other in North America, using prevention of secondary malignancy as the primary study end-point. Until these trials are completed, the use of chemoprevention in head and neck cancer should be limited to clinical trials.

Tài liệu tham khảo

Vokes EE, Weichselbaum RR, Lippman SM, Hong WK: Head and neck cancer. N Engl J Med 328: 184–194, 1993 Slaughter DP, Southwick HW, Smejkal W: ‘Field cancerization’ in oral stratified squamous epithelium: clinical implications of multicentric origin. Cancer 6: 963–968, 1953 Cohn AM, Peppard SB: Multiple primary malignant tumors of the head and neck. Am J Otolaryngol 1: 411–417, 1980 Johnson NW, Ranasinghe AW, Warnakulasuriya: Potentially malignant lesions and conditions of the mouth and oropharynx: natural history-cellular and molecular markers of risk. Eur J Cancer Prev 2: 31–51, 1993 Silverman SJr, Gorsky M, Lozada F: Oral leukoplakia and malignant transformation. Cancer Res 52: 2758–2763, 1992 Bouquot JE, Gorlin RJ: Leukoplakia, lichen planus and other oral keratoses in 23616 white Americans over the age of 35 years. Oral Surg 61: 373–381, 1986 Daftari DK, Murti PR, Bhonsle RB, Gupta PC, Metha FS, Pindborg JJ: Oral precancerous lesions and conditions of tropical interest. In: Prabhu SR, Wilson DF, Daftari DK, Johnson NW (eds) Oral Diseases in the Tropics. Oxford Medical Publications, Oxford, 1992, pp 402–428 Shafer WG, Waldron CA: Erythroplakia of the oral cavity. Cancer 36: 1021–1028, 1975 Lippman SM, Hong WK: Second malignant tumors in head and neck squamous cell carcinoma: the overshadowing threat for patients with early stage disease. Int J Radiat Oncol Biol Phys 17: 691–694, 1989 Lotan R, Xu XC, Lippman SM, Ro JY, Lee JJ, Hong WK: Suppression of retinoic acid receptor-beta in premalignant oral lesions and its up-regulation by isotretinoin. N Engl J Med 322: 1405–1410, 1995 Silverman S, Renstrup G, Pindborg JJ: Studies in oral leukoplakia. Acta Odontol Scan 21: 271–292, 1963 Silverman S, Eisenberg E, Renstrup G: A study of the effects of vitamin A on oral leukoplakia (hyperkeratosis), including toxicity, liver function and skeletal metabolism. J Oral Ther Pharmacol 2: 9–23, 1965 Raque CJ, Biondo RV, Keeran MG, Honeycutt WM, Jansen GT: Snuff dippers keratosis (Snuff induced leukoplakia). South Med J 68: 565–568, 1975 Koch HF: Biochemical treatment of precancerous oral lesions: The effectiveness of various analogues of retinoic acid. J Max Fac Surg 6: 59–63, 1978 Koch HF: Effects of retinoids on precancerous lesions of oral mucosa. In: Orfanos CE, Braun-Falco O, Farber EM, Gruper Ch, Polano MK, Schuppli R (eds) Retinoids. Advances in Basic Research and Therapy. Springer-Verlag, Berlin, Heidelberg, New York, 1981, pp 307–312 Hong WK, Endicott J, Itri LM, Doos W, Batsakis JG, Bell R, Fofonoff S, Byers R, Atkinson EN, Vaughan C, Toth BB, Kramer A, Dimery IW, Skipper P, Strong S: 13-cis-retinoic acid in the treatment of oral leukoplakia. N Engl J Med 315: 1501–1505, 1986 Toma S, Mangiante PE, Margarino G, Nicolo G, Palumbo R: Progressive 13-cis-retinoic acid dosage in the treatment of oral leukoplakia. Oral Oncol Eur J Cancer 28B: 121–123, 1992 Shekelle RB, Lepper M, Liu S, et al.: Dietary vitamin A and risk of cancer in the Western Electric Study. Lancet 2: 1185–1190, 1981 Garewall ER, Meyskens FLJr, Kellen D, Reeves D, Kiersch TA, Elletson H, Stosberg A, King D, Steinbronn: Responses of oral leukoplakia to β-carotene. J Clin Oncol 8: 1715–1720, 1990 Toma S, Albanese E, DeLorenzi M, et al.: β-carotene in the treatment of oral leukoplakia. (Abstract) Proc Am Soc Clin Oncol 9: 179, 1990 Malaker K, Anderson B, Beecroft W, Hodson D: Management of oral mucosal dysplasia with β-carotene and retinoic acid: a pilot cross-over study. Cancer Detect Prev 15: 335–340, 1991 Lippman SM, Batsakis JG, Toth BB, Weber RS, Lee JJ, Martin JW, Hays GL, Goepfert H, Hong WK: Comparison of low-dose isotretinoin with carotene to prevent oral carcinogenesis. N Engl J Med 328: 15–20, 1993 Chiesa F, Tradati N, marazza M, Rossi N, Boracchi P, Mariani L, Clerici M, Formelli F, Barzan L, Carrasi A, Pastorini A, Camerini T, Giardini R, Zurrida S, Minn FL, Costa A, De Palo G, Veronesi U: Prevention of local relapses and new localisations of oral leukoplakia with the synthetic retinoid fenretidine (4-HPR). Preliminary results. Oral Oncol Eur J Cancer 28B: 97–102, 1992 Besa EC, Abrahm JL, Bartholomew MJ, Hysinski M, Nowell PC: Treatment with 13-cis-retinoic acid in transfusion-dependent patients with myelodysplastic syndrome and decreased toxicity with the addition of α-tocopherol. Am J Med 89: 739–747, 1990 Dimery I, Shirinian M, Heyne K, Lippman SM, Fritsche H, Guillary C, Fossella S, Shin D, Hong WK: Reduction in toxicity of high dose 13-cis-retinoic acid (13-cRA) with α-tocopherol (AT). (Abstract) Proc Am Soc Clin Oncol 11: 399, 1992 Benner SE, Winn RJ, Lippman SM, Poland J, Hansen KS, Luna MA, Hong WK: Regression of oral leukoplakia with α-tocopherol: A community clinical oncology program chemoprevention study. J Natl Cancer Inst 85: 44–47, 1993 Shamberger RJ, Rukovena E, Lonfield AK, Tytko SA, Deodhar S, Willis CE: Antioxidants and cancer. I. Selenium in the blood of normal and cancer patients. J Natl Cancer Inst 4: 4863–4870, 1973 Temple NJ, Basu TK: Selenium and cabbage and colon carcinogenesis in mice. J Natl Cancer Inst 5: 1131–1134, 1987 Toma S, Micheletti A, Giachero A, Coialbu T, Collechi P, Esposito M, Rotondi M, Albanese E, Cantoni E: Selenium therapy in patients with precancerous and malignant oral cavity lesions: Preliminary results. Cancer Prev Detect 15: 491–494, 1991 Hong WK, Lippman SM, Itri LM, Karp DD, Lee JS, Byers RM, Schantz SP, Kramer AM, Lotan R, Peters LJ, Dimery IW, Brown BW, Goepfert H: Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck. N Engl J Med 323: 795–801, 1990 Benner SE, Pajak TF, Lippman SM, Early C, Hong WK: Prevention of second primary tumors with isotretinoin in patients with squamous cell carcinoma of the head and neck: Long-term follow-up. J Natl Cancer Inst 86: 140–141, 1994 Bolla M, Lefur R, TonVan J, Domenge C, Badet JM, Koskas Y, Laplanche A: Prevention of second primary tumours with etretinate in squamous cell carcinoma of the oral cavity and oropharynx. Results of a multicentric double-blind randomised study. Eur J Cancer 30A: 767–772, 1994 Pastorino U, Infante M, Maioli M, Chiesa G, Buyse M, Firket P, Rosmentz N, Clerici M, Soresi E, Valente M, Bellone PA, Ravasi G: Adjuvant treatment of stage I lung cancer with high-dose vitamin A. J Clin Oncol 11: 1216–1222, 1993 Van Zandwijk N, Pastorino U, De Vries N, Dalesio O: Euroscan: the European Organization for Research and Treatment of Cancer (EORTC): Chemoprevention study in lung cancer. Lung Cancer 9: 351–356, 1993 Pastorino U, Van Zandwijk N, De Vries N, Dalesio O, Van Tinteren H: Results of the Euroscan trial. Proc Seventh World Conference on Lung Cancer. Lung Cancer 11: 94–95, 1994