Clinical phase I and pharmacokinetic trial of the new titanium complex budotitane

Tassilo Schilling1, K. B. Keppler2, Manfred Heim3, G. Niebch4, Hermann Dietzfelbinger1, J. Rastetter1, Axel‐R. Hanauske1
1Division of Hematology and Oncology, Klinikum rechts der Isar der Technischen Universität München, FRG.
2Anorganisch‐chemisches Institut der Universität Heidelberg (FRG)
3Sonnenberg-Klinik, Bad Sooden-Allendorf, FRG
4ASTA Medica AF, Frankfurt/M., FRG

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Keller HJ, Keppler BK, Schmähl D: Antitumor activity of cis-dihalogenobis(1-phenyl-1,3-butane-dionato)titanium(IV) compounds against Walker carcinosarcoma. Arzneimittel-Forsch/Drug Res 32:806–807, 1982

Keppler BK, Heim ME: Antitumor-active bis-β-diketonato metal complexes: budotitane — a new anticancer agent. Drugs of the Future 13:637–652, 1988

Keppler BK, Michels K: Antitumor activity of 1,3-diketonato zirconium (IV) and hafnium (IV) complexes. Arzneimittel-Forsch/Drug Res 35:1837–1839, 1985

Keppler BK, Schmähl D: Preclinical evaluation of dichlorbis(1-phenylbutane-1,3-dionato)titanium (IV) and budotitane. Arzneimittel-Forsch/Drug Res 36:1822–1826, 1986

Bischoff H, Berger MR, Keppler BK, Schmähl D: Efficacy of β-diketonato complexes of titanium, zirconim and hafnium against chemically induced autochtonous colonic tumors in rats. J Cancer Res Clin Oncol 113: 446–450, 1987

Keppler BK, Heim ME, Flechtner H, Wingen F, Pool BL: Assessment of preclinical activity of budotitane in three different transplantable tumor systems, its mutagenicity, and first results of clinical phase I studies. Arzneimittel-Forsch/Drug Res 39:706–709, 1989

Heim ME, Flechner H, Keppler BK, Queißer W: Clinical studies with budotitane, a new non-platinum metal complex for cancer therapy. Contrib Oncol 37:168–175, 1989

WHO Handbook for reporting results of cancer treatment. WHO publication 48 (World Health Organisation), Geneva, 1979

Heinzel G, Woloszczak A, Thomann P: TOPFIT 2.0: Pharmacokinetic and Pharmacodynamic Data Analysis System for the PC. G. Fischer Verlag, Stuttgart/Jena/ New York, 1993

Canobbio L, Fassio T, Gasparini G, Caruso G, Barzan L, Comoretto R, Brema F, Villani F: Cardiac arrhythmia: possible complication from treatment with cisplatin. Tumori 72:201–204, 1986

Tasaka T, Fujita J, Yamaji Y, Hata Y, Bungo M, Nakamura H, Shiotani T, Irino S: A case of second-degree atrioventricular block caused by high dose cisplatin treatment. Gan To Kagaku Ryoho 18:1047–1050, 1991

Petrella V, Alciato P, Cantone PA, Fico D, Gagliardini R: High-frequency atrial arrhythmia induced by a cisplatin-etoposide combination. Minerva-Med 80:305–307, 1989

Low-Friedrich I, von Bredow F, Schoeppe W:In vitro studies on the cardiotoxicity of chemotherapeutics. Chemotherapy 36:416–421, 1990