Clinical efficacy of intravitreal aflibercept versus panretinal photocoagulation for best corrected visual acuity in patients with proliferative diabetic retinopathy at 52 weeks (CLARITY): a multicentre, single-blinded, randomised, controlled, phase 2b, non-inferiority trial

The Lancet - Tập 389 Số 10085 - Trang 2193-2203 - 2017
Sobha Sivaprasad1, A Toby Prevost2, Joana C. Vasconcelos2, Amy Riddell3, Caroline Murphy3, Joanna Kelly3, James Bainbridge4, Rhiannon Tudor Edwards5, David Hopkins6, Philip Hykin1, Ajay S. Bhatnagar, Ben Burton7,5,6,8,3,9,10,10,11,12, Usha Chakravarthy7,5,6,8,3,9,10,10,11,12, Haralabos Eleftheriadis7,5,6,8,3,9,10,10,11,12, Theodoros Empeslidis7,5,6,8,3,9,10,10,11,12, Richard Gale7,5,6,8,3,9,10,10,11,12, Sheena George7,5,6,8,3,9,10,10,11,12, Maged Habib7,5,6,8,3,9,10,10,11,12, Scott P. Kelly7,5,6,8,3,9,10,10,11,12, Andrew Lotery, Martin McKibbin7,5,6,8,3,9,10,10,11,12, Luke Membrey7,5,6,8,3,9,10,10,11,12, Geeta Menon7,5,6,8,3,9,10,10,11,12, Bushra Mushtaq7,5,6,8,3,9,10,10,11,12, Luke Nicholson7,5,6,8,3,9,10,10,11,12, Jayashree Ramu7,5,6,8,3,9,10,10,11,12, Olayinka Osoba7,5,6,8,3,9,10,10,11,12, Jawaharlal M. Patel7,5,6,8,3,9,10,10,11,12, Priya Prakash7,5,6,8,3,9,10,10,11,12, Robert Purbrick7,5,6,8,3,9,10,10,11,12, Adam H. Ross, Amira Stylianides, James Talks7,5,6,8,3,9,10,10,11,12, Simon Harding7,5,6,8,3,9,10,10,11,12, Tünde Petõ7,5,6,8,3,9,10,10,11,12, Seow Tien Yeo7,5,6,8,3,9,10,10,11,12, Alistair Laidlaw, Winfried M. K. Amoaku, Gillian Hood, G. A. Hitman, Dan Preece, Paul Burns, Sarah Walker, Evelyn Mensah, Niral Karia
1National Institute for Health Research, Moorfields Biomedical Research Centre, London, UK
2Imperial Clinical Trials Unit, School of Public Health, Imperial College London, London, UK
3King’s Clinical Trials Unit at King’s Health Partners, King’s College London, London, UK
4University College London Institute of Ophthalmology, London, UK
5Centre for Health Economics and Medicines Evaluation, Bangor University, Bangor, Gwynedd, UK
6Department of Diabetes and Endocrinology, King’s College Hospital NHS Foundation Trust, London, UK
7 Clinical Trials Unit at King's Health Partners, King's College London, London, UK.
8Imperial Clinical Trials Unit, School of Public Health, Imperial College London
9NIHR Moorfields Biomedical Research Centre 162, City Road London EC1V 2PD
10NIHR Moorfields Biomedical Research Centre, London, UK
11National Institute for Health Research partnership; Aflibercept was supplied by Bayer Plc, Reading, UK.
12UCL Institute of Ophthalmology, 11-43 Bath Street, London, UK.

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The Lancet

Tập 389 Số 10085

2193-2203

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