Clinical efficacy and safety of stem cells in refractory Crohn's disease: A systematic review

Fofanova, 2016, Microbiome-epigenome interactions and the environmental origins of inflammatory bowel diseases, J Pediatr Gastroenterol Nutr, 62, 08, 10.1097/MPG.0000000000000950 Nielsen, 2009, Diagnosis and management of fistulizing Crohn's disease, Nat Clin Pract Gastroenterol Hepatol, 6, 92, 10.1038/ncpgasthep1340 Flores, 2015, Stem cell therapy in inflammatory bowel disease: a promising therapeutic strategy?, World J Stem Cells, 7, 343, 10.4252/wjsc.v7.i2.343 Gazouli, 2014, Stem cells as potential targeted therapy for inflammatory bowel disease, Inflamm Bowel Dis, 20, 952, 10.1097/01.MIB.0000442922.85569.21 Ma, 2015, Hematopoietic stem cells, Stem Cell, 6, 27 Muraro, 2010, Immuno-therapeutic potential of haematopoietic and mesenchymal stem cell transplantation in MS, Results Probl Cell Differ, 51, 237, 10.1007/400_2008_14 Kavanagh, 2011, Hematopoietic stem cell homing to injured tissues, Stem Cell Rev, 7, 672, 10.1007/s12015-011-9240-z Hass, 2011, Different populations and sources of human mesenchymal stem cells (MSC): a comparison of adult and neonatal tissue-derived MSC, Cell Commun Signal, 14, 12, 10.1186/1478-811X-9-12 Lanzoni, 2008, Inflammatory bowel disease: moving toward a stem cell-based therapy, World J Gastroenterol, 14, 4616, 10.3748/wjg.14.4616 Eggenhofer, 2014, The life and fate of mesenchymal stem cells, Front Immunol, 5, 148, 10.3389/fimmu.2014.00148 Figueroa, 2012, Mesenchymal Stem Cell treatment for autoimmune diseases: a critical review, Biol Res, 45, 269, 10.4067/S0716-97602012000300008 Liao, 2008, An overview of stem cell-based clinical trials in China, Stem Cells Dev, 17, 613, 10.1089/scd.2008.0183 Booth, 2010, Centre for reviews and dissemination databases: value, content, and developments, Int J Technol Assess Health Care, 26, 470, 10.1017/S0266462310000978 Moher, 2009, Reprint–preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement, Phys Ther, 89, 873, 10.1093/ptj/89.9.873 Wells, 2011 Oyama, 2005, Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's disease, Gastroenterology, 128, 552, 10.1053/j.gastro.2004.11.051 Burt, 2010, Autologous nonmyeloablative hematopoietic stem cell transplantation in patients with severe anti-TNF refractory Crohn disease: long-term follow-up, Blood, 116, 6123, 10.1182/blood-2010-06-292391 Cassinotti, 2012, Autologous haematopoietic stem cell transplantation without CD34 cell selection for refractory Crohn's disease: the Milan experience after 5 years, J Crohns Colitis, 6, S153, 10.1016/S1873-9946(12)60381-X Hasselblatt, 2012, Remission of refractory Crohn's disease by high-dose cyclophosphamide and autologous peripheral blood stem cell transplantation, Aliment Pharmacol Ther, 36, 725, 10.1111/apt.12032 Lopez-Cubero, 1998, Course of Crohn's disease after allogeneic marrow transplantation, Gastroenterology, 114, 433, 10.1016/S0016-5085(98)70525-6 Hommes, 2011, Long-term follow-up of autologous hematopoietic stem cell transplantation for severe refractory Crohn's disease, J Crohns Colitis, 5, 543, 10.1016/j.crohns.2011.05.004 Onken, 2006, Successful outpatient treatment of refractory Cron's disease using adult mesenchymal stem cells Duijvestein, 2010, Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study, Gut, 59, 1662, 10.1136/gut.2010.215152 Liang, 2012, Allogeneic mesenchymal stem cell transplantation in seven patients with refractory inflammatory bowel disease, Gut, 61, 468, 10.1136/gutjnl-2011-300083 Forbes, 2014, A phase 2 study of allogeneic mesenchymal stromal cells for luminal Crohn's disease refractory to biologic therapy, Clin Gastroenterol Hepatol, 12, 64, 10.1016/j.cgh.2013.06.021 Lazebnik, 2010, Use of allogeneic mesenchymal stem cells in the treatment of intestinal inflammatory diseases, Ter Arkh, 82, 38 García-Olmo, 2005, A phase I clinical trial of the treatment of Crohn's fitula by adipose mesenchymal stem cell transplantation, Dis Colon Rectum, 48, 1416, 10.1007/s10350-005-0052-6 Garcia-Olmo, 2009, Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase II clinical trial, Dis Colon Rectum, 52, 79, 10.1007/DCR.0b013e3181973487 Ciccocioppo, 2011, Autologous bone marrow derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease, Gut, 60, 788, 10.1136/gut.2010.214841 De la Portilla, 2013, Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fitula in Crohn's disease: results from a multicenter phase I/IIa clinical trial, Int J Colorectal Dis, 28, 313, 10.1007/s00384-012-1581-9 Cho, 2013, Autologous adipose tissue-derived stem cells for the treatment of Crohn's fitula: a phase I clinical study, Cell Transpl, 22, 279, 10.3727/096368912X656045 Lee, 2013, Autologous adipose tissue-derived stem cells treatment demonstrated favorable and sustainable therapeutic effect for Crohn's fitula, Stem Cells, 31, 2575, 10.1002/stem.1357 Herreros, 2012, Garcia-OD Autologous expanded adipose-derived stem cells for the treatment of complex cryptoglandular perianal fistulas: a phase III randomized clinical trial (FATT 1: fistula Advanced Therapy Trial 1) and long-term evaluation, Dis Colon Rectum, 55, 762, 10.1097/DCR.0b013e318255364a Wagnerova, 2013, In vivo reprogramming in inflammatory bowel disease, Gene Ther, 20, 1111, 10.1038/gt.2013.43 Baumgart, 2012, Crohn's disease, Lancet, 380, 1590, 10.1016/S0140-6736(12)60026-9 De Iudicibus, 2013, MicroRNAs as tools to predict glucocorticoid response in inflammatory bowel diseases, World J Gastroenterol, 19, 7947, 10.3748/wjg.v19.i44.7947 Colombel, 2014, IBD therapy: new targets and unmet needs, Nestle Nutr Inst Workshop Ser, 79, 153, 10.1159/000360720 Bernstein, 2015, Treatment of IBD: where we are and where we are going, Am J Gastroenterol, 110, 114, 10.1038/ajg.2014.357 Baert, 2010, Mucosal healing predicts sustained clinical remission in patients with early-stage Crohn's disease, Gastroenterology, 138, 463, 10.1053/j.gastro.2009.09.056 Peyrin-Biroulet, 2013, First-line therapy in adult Crohn's disease: who should receive anti-TNF agents?, Nat Rev Gastroenterol Hepatol, 10, 345, 10.1038/nrgastro.2013.31 Daley, 2008, Prospects for stem cell-based therapy, Cell, 132, 544, 10.1016/j.cell.2008.02.009 Lazzeri, 2015, Stem cell therapy for kidney disease, Expert Opin Biol Ther, 10, 1 Griffin, 2013, Concise review: adult mesenchymal stromal cell therapy for inflammatory diseases: how well are we joining the dots?, Stem Cells, 31, 2033, 10.1002/stem.1452 Singh, 2010, Stem cells as potential therapeutic targets for inflammatory bowel disease, Front Biosci (Schol Ed), 2, 993, 10.2741/s115 Sánchez, 2011, Enrichment of human ESC-derived multipotent mesenchymal stem cells with immunosuppressive and anti-inflammatory properties capable to protect against experimental inflammatory bowel disease, Stem Cells, 29, 251, 10.1002/stem.569 Qu, 2015, Transplantation of bone marrow-derived mesenchymal stem cells facilitates epithelial repair and relieves the impairment of gastrointestinal function in a rat model of enteritis, Clin Res Hepatol Gastroenterol, 39, 114, 10.1016/j.clinre.2014.07.015 Doucet, 2015, Isolation and functional assessment of cutaneous stem cells, Methods Mol Biol, 1235, 147, 10.1007/978-1-4939-1785-3_13 Nemoto, 2013, Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4 memory T cells, Gut, 62, 1142, 10.1136/gutjnl-2012-302029 Romani, 2015, Stem cells from human amniotic fluid exert immunoregulatory function via secreted indoleamine 2,3-dioxygenase1, J Cell Mol Med, 19, 1593, 10.1111/jcmm.12534