Clinical characteristics of 140 patients infected with SARS‐CoV‐2 in Wuhan, China

Allergy: European Journal of Allergy and Clinical Immunology - Tập 75 Số 7 - Trang 1730-1741 - 2020
Jinjin Zhang1, Xiang Dong1, Yiyuan Cao2, Yadong Yuan3, Yibin Yang4, Youqin Yan5, Cezmi A. Akdiş6, Yadong Gao1
1Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China
2Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China
3Department of Respiratory and Critical Care Medicine, Second Hospital of Hebei Medical University, Shijiazhuang, China
4Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China
5Department of Infectious Disease, No. 7 Hospital of Wuhan, Wuhan, China
6Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland

Tóm tắt

AbstractBackgroundCoronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection has been widely spread. We aim to investigate the clinical characteristic and allergy status of patients infected with SARS‐CoV‐2.MethodsElectronic medical records including demographics, clinical manifestation, comorbidities, laboratory data, and radiological materials of 140 hospitalized COVID‐19 patients, with confirmed result of SARS‐CoV‐2 viral infection, were extracted and analyzed.ResultsAn approximately 1:1 ratio of male (50.7%) and female COVID‐19 patients was found, with an overall median age of 57.0 years. All patients were community‐acquired cases. Fever (91.7%), cough (75.0%), fatigue (75.0%), and gastrointestinal symptoms (39.6%) were the most common clinical manifestations, whereas hypertension (30.0%) and diabetes mellitus (12.1%) were the most common comorbidities. Drug hypersensitivity (11.4%) and urticaria (1.4%) were self‐reported by several patients. Asthma or other allergic diseases were not reported by any of the patients. Chronic obstructive pulmonary disease (COPD, 1.4%) patients and current smokers (1.4%) were rare. Bilateral ground‐glass or patchy opacity (89.6%) was the most common sign of radiological finding. Lymphopenia (75.4%) and eosinopenia (52.9%) were observed in most patients. Blood eosinophil counts correlate positively with lymphocyte counts in severe (r = .486, P < .001) and nonsevere (r = .469, P < .001) patients after hospital admission. Significantly higher levels of D‐dimer, C‐reactive protein, and procalcitonin were associated with severe patients compared to nonsevere patients (all P < .001).ConclusionDetailed clinical investigation of 140 hospitalized COVID‐19 cases suggests eosinopenia together with lymphopenia may be a potential indicator for diagnosis. Allergic diseases, asthma, and COPD are not risk factors for SARS‐CoV‐2 infection. Older age, high number of comorbidities, and more prominent laboratory abnormalities were associated with severe patients.

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Allergy: European Journal of Allergy and Clinical Immunology

Tập 75 Số 7

1730-1741

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