Clinical cell therapy guidelines for neurorestoration (IANR/CANR 2022)

Huang, 2018, Clinical cell therapy guidelines for neurorestoration (IANR/CANR 2017), Cell Transplant, 27, 310, 10.1177/0963689717746999 Wang, 2021, A pilot study of clinical cell therapy for patients with vascular dementia, J Neurorestoratol, 9, 137, 10.26599/JNR.2021.9040011 Wang, 2020, Olfactory ensheathing cells in chronic ischemic stroke: a phase 2, double-blind, randomized, controlled trial, J Neurorestoratol, 8, 182, 10.26599/JNR.2020.9040019 Guo, 2019, Olfactory ensheathing cell transplantation improving cerebral infarction sequela: a case report and literature review, J Neurorestoratol, 7, 82, 10.26599/JNR.2019.9040009 Kuang, 2021, Olfactory ensheathing cell transplantation for chronic spinal cord injury: a long-term follow-up study, J Neurorestoratol, 9, 94, 10.26599/JNR.2021.9040008 Cheng, 2021, Ten years of clinical observation of olfactory ensheathing cell transplantation in patients with spinal cord injury, J Neurorestoratol, 9, 106, 10.26599/JNR.2021.9040009 Hammadi, 2019, Intra-arterial injection of autologous bone marrow-derived mononuclear cells in ischemic stroke patients, Exp Clin Transplant, 17, 239, 10.6002/ect.MESOT2018.P102 Haque, 2019, Serial cerebral metabolic changes in patients with ischemic stroke treated with autologous bone marrow derived mononuclear cells, Front Neurol, 10, 141, 10.3389/fneur.2019.00141 Liem, 2018, Improved bowel function in patients with spina bifida after bone marrow-derived mononuclear cell transplantation: a report of 2 cases, Am J Case Rep, 19, 1010, 10.12659/AJCR.909801 Liem, 2019, Outcomes of bone marrow mononuclear cell transplantation for neurological sequelae due to intracranial hemorrhage incidence in the neonatal period: report of four cases, Front Pediatr, 7, 543, 10.3389/fped.2019.00543 Liem, 2020, Outcomes of bone marrow-derived mononuclear cell transplantation for patients in persistent vegetative state after drowning: report of five cases, Front Pediatr, 8, 564, 10.3389/fped.2020.00564 Cox, 2017, Treatment of severe adult traumatic brain injury using bone marrow mononuclear cells, Stem Cell, 35, 1065, 10.1002/stem.2538 Bhasin, 2017, Safety and feasibility of autologous mesenchymal stem cell transplantation in chronic stroke in Indian patients. A four-year follow up, J Stem Cells Regen Med, 13, 14 Laskowitz, 2018, Allogeneic umbilical cord blood infusion for adults with ischemic stroke: clinical outcomes from a phase I safety study, Stem Cells Transl Med, 7, 521, 10.1002/sctm.18-0008 Bhatia, 2018, Randomized assessment of the safety and efficacy of intra-arterial infusion of autologous stem cells in subacute ischemic stroke, AJNR Am J Neuroradiol, 39, 899, 10.3174/ajnr.A5586 Sharma, 2018, An open-label proof-of-concept study of intrathecal autologous bone marrow mononuclear cell transplantation in intellectual disability, Stem Cell Res Ther, 9, 19, 10.1186/s13287-017-0748-2 Sharma, 2020, Intrathecal transplantation of autologous bone marrow mononuclear cells in patients with sub-acute and chronic spinal cord injury: an open-label study, Int J Health Sci, 14, 24 Sharma, 2020, Autologous bone marrow mononuclear cell transplantation in patients with chronic traumatic brain injury- a clinical study, Cell Regen, 9, 3, 10.1186/s13619-020-00043-7 Sharma, 2021, Improved survival in amyotrophic lateral sclerosis patients following autologous bone marrow mononuclear cell therapy: a long term 10-year retrospective study, J Neurorestoratol, 9, 117, 10.26599/JNR.2021.9040010 Nguyen, 2017, Outcomes of autologous bone marrow mononuclear cells for cerebral palsy: an open label uncontrolled clinical trial, BMC Pediatr, 17, 104, 10.1186/s12887-017-0859-z Nguyen, 2018, The effects of bone marrow mononuclear cell transplantation on the quality of life of children with cerebral palsy, Health Qual Life Outcome, 16, 164, 10.1186/s12955-018-0992-x Nguyen Thanh, 2021, Outcomes of bone marrow mononuclear cell transplantation combined with interventional education for autism spectrum disorder, Stem Cells Transl Med, 10, 14, 10.1002/sctm.20-0102 Chernykh, 2018, Monocyte-derived macrophages for treatment of cerebral palsy: a study of 57 cases, J Neurorestoratol, 6, 41, 10.2147/JN.S158843 Srivastava, 2019, Effectiveness of bone marrow-derived mononuclear stem cells for neurological recovery in participants with spinal cord injury: a randomized controlled trial, Asian J Transfus Sci, 13, 120, 10.4103/ajts.AJTS_44_18 Derakhshanrad, 2018, Subcutaneous granulocyte colony-stimulating factor administration for subacute traumatic spinal cord injuries, report of neurological and functional outcomes: a double-blind randomized controlled clinical trial, J Neurosurg Spine, 30, 19, 10.3171/2018.6.SPINE18209 Derakhshanrad, 2018, Granulocyte-colony stimulating factor administration for neurological improvement in patients with postrehabilitation chronic incomplete traumatic spinal cord injuries: a double-blind randomized controlled clinical trial, J Neurosurg Spine, 29, 97, 10.3171/2017.11.SPINE17769 Syková, 2017, Transplantation of mesenchymal stromal cells in patients with amyotrophic lateral sclerosis: results of phase I/IIa clinical trial, Cell Transplant, 26, 647, 10.3727/096368916X693716 Tsang, 2017, Phase I/II randomized controlled trial of autologous bone marrow-derived mesenchymal stem cell therapy for chronic stroke, World J Stem Cell, 9, 133, 10.4252/wjsc.v9.i8.133 Levy, 2019, Phase I/II study of safety and preliminary efficacy of intravenous allogeneic mesenchymal stem cells in chronic stroke, Stroke, 50, 2835, 10.1161/STROKEAHA.119.026318 Brunet, 2019, Intravenous stem cell therapy for high-grade aneurysmal subarachnoid hemorrhage: case report and literature review, World Neurosurg, 128, 573, 10.1016/j.wneu.2019.04.055 Ahn, 2021, Treatment of acute ischemic stroke by minimally manipulated umbilical cord-derived mesenchymal stem cells transplantation: a case report, World J Stem Cell, 13, 1151, 10.4252/wjsc.v13.i8.1151 Larocca, 2017, Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study, Cytotherapy, 19, 1189, 10.1016/j.jcyt.2017.06.006 Guadalajara Labajo, 2018, Objective demonstration of improvement of neurogenic bowel dysfunction in a case of spinal cord injury following stem cell therapy, J Surg Case Rep, 2018, rjy300 Santamaría, 2019, Clinical and neurophysiological changes after targeted intrathecal injections of bone marrow stem cells in a C3 tetraplegic subject, J Neurotrauma, 36, 500, 10.1089/neu.2018.5716 Vaquero, 2017, Repeated subarachnoid administrations of autologous mesenchymal stromal cells supported in autologous plasma improve quality of life in patients suffering incomplete spinal cord injury, Cytotherapy, 19, 349, 10.1016/j.jcyt.2016.12.002 Vaquero, 2017, Progressive increase in brain glucose metabolism after intrathecal administration of autologous mesenchymal stromal cells in patients with diffuse axonal injury, Cytotherapy, 19, 88, 10.1016/j.jcyt.2016.10.001 Vaquero, 2018, Intrathecal administration of autologous bone marrow stromal cells improves neuropathic pain in patients with spinal cord injury, Neurosci Lett, 670, 14, 10.1016/j.neulet.2018.01.035 Vaquero, 2018, Intrathecal administration of autologous mesenchymal stromal cells for spinal cord injury: safety and efficacy of the 100/3 guideline, Cytotherapy, 20, 806, 10.1016/j.jcyt.2018.03.032 Vaquero, 2018, Cell therapy with autologous mesenchymal stromal cells in post-traumatic syringomyelia, Cytotherapy, 20, 796, 10.1016/j.jcyt.2018.04.006 Vaquero, 2019, Intrathecal cell therapy with autologous stromal cells increases cerebral glucose metabolism and can offer a new approach to the treatment of Alzheimer's type dementia, Cytotherapy, 21, 428, 10.1016/j.jcyt.2019.02.009 Bydon, 2020, CELLTOP clinical trial: first report from a phase 1 trial of autologous adipose tissue-derived mesenchymal stem cells in the treatment of paralysis due to traumatic spinal cord injury, Mayo Clin Proc, 95, 406, 10.1016/j.mayocp.2019.10.008 Phedy, 2019, Motoric recovery after transplantation of bone marrow derived mesenchymal stem cells in chronic spinal cord injury: a case report, Am J Case Rep, 20, 1299, 10.12659/AJCR.917624 Yang, 2021, Repeated subarachnoid administrations of allogeneic human umbilical cord mesenchymal stem cells for spinal cord injury: a phase 1/2 pilot study, Cytotherapy, 23, 57, 10.1016/j.jcyt.2020.09.012 Huang, 2018, A randomized, placebo-controlled trial of human umbilical cord blood mesenchymal stem cell infusion for children with cerebral palsy, Cell Transplant, 27, 325, 10.1177/0963689717729379 Boruczkowski, 2019, Wharton's jelly mesenchymal stem cell administration improves quality of life and self-sufficiency in children with cerebral palsy: results from a retrospective study, Stem Cell Int, 2019 Boruczkowski, 2019, A retrospective analysis of safety and efficacy of wharton's jelly stem cell administration in children with spina bifida, Stem Cell Rev Rep, 15, 717, 10.1007/s12015-019-09902-6 Kabataş, 2021, Phase I study on the safety and preliminary efficacy of allogeneic mesenchymal stem cells in hypoxic-ischemic encephalopathy, World J Exp Med, 11, 17, 10.5493/wjem.v11.i2.17 Kabatas, 2021, Feasibility of allogeneic mesenchymal stem cells in pediatric hypoxic-ischemic encephalopathy: phase I study, World J Stem Cell, 13, 470, 10.4252/wjsc.v13.i5.470 Riordan, 2019, Allogeneic human umbilical cord mesenchymal stem cells for the treatment of autism spectrum disorder in children: safety profile and effect on cytokine levels, Stem Cells Transl Med, 8, 1008, 10.1002/sctm.19-0010 Pan, 2019, Safety and feasibility of repeated intrathecal allogeneic bone marrow-derived mesenchymal stromal cells in patients with neurological diseases, Stem Cell Int, 2019, 8421281 Numan, 2017, Autologous adipose stem cell therapy for autonomic nervous system dysfunction in two young patients, Stem Cell Dev, 26, 391, 10.1089/scd.2016.0196 Albu, 2021, Clinical effects of intrathecal administration of expanded Wharton jelly mesenchymal stromal cells in patients with chronic complete spinal cord injury: a randomized controlled study, Cytotherapy, 23, 146, 10.1016/j.jcyt.2020.08.008 Zhao, 2020, Intravenous infusion of umbilical cord mesenchymal stem cells maintains and partially improves visual function in patients with advanced retinitis pigmentosa, Stem Cell Dev, 29, 1029, 10.1089/scd.2020.0037 Tuekprakhon, 2021, Intravitreal autologous mesenchymal stem cell transplantation: a non-randomized phase I clinical trial in patients with retinitis pigmentosa, Stem Cell Res Ther, 12, 52, 10.1186/s13287-020-02122-7 Tsai, 2017, Treatment of spinocerebellar Ataxia with mesenchymal stem cells: a phase I/IIa clinical study, Cell Transplant, 26, 503, 10.3727/096368916X694373 Oh, 2018, Repeated intrathecal mesenchymal stem cells for amyotrophic lateral sclerosis, Ann Neurol, 84, 361, 10.1002/ana.25302 Barczewska, 2020, Umbilical cord mesenchymal stem cells in amyotrophic lateral sclerosis: an original study, Stem Cell Rev Rep, 16, 922, 10.1007/s12015-020-10016-7 Petrou, 2021, A phase II clinical trial with repeated intrathecal injections of autologous mesenchymal stem cells in patients with amyotrophic lateral sclerosis, Front Biosci (Landmark Ed), 26, 693, 10.52586/4980 Kobinia, 2021, Case report: autologous bone marrow derived intrathecal stem cell transplant for autistic children - a report of four cases and literature review, Front Pediatr, 9, 620188, 10.3389/fped.2021.620188 Sharifzadeh, 2021, Intrathecal autologous bone marrow stem cell therapy in children with autism: a randomized controlled trial, Asia Pac Psychiatr, 13, 10.1111/appy.12445 Honmou, 2021, Intravenous infusion of auto serum-expanded autologous mesenchymal stem cells in spinal cord injury patients: 13 case series, Clin Neurol Neurosurg, 203, 106565, 10.1016/j.clineuro.2021.106565 Anderson, 2017, Safety of autologous human schwann cell transplantation in subacute thoracic spinal cord injury, J Neurotrauma, 34, 2950, 10.1089/neu.2016.4895 Santamaria, 2020, Neurophysiological changes in the first year after cell transplantation in sub-acute complete paraplegia, Front Neurol, 11, 514181, 10.3389/fneur.2020.514181 Gant, 2022, Phase 1 safety trial of autologous human schwann cell transplantation in chronic spinal cord injury, J Neurotrauma, 39, 285, 10.1089/neu.2020.7590 Goutman, 2018, Long-term Phase 1/2 intraspinal stem cell transplantation outcomes in ALS, Ann Clin Transl Neurol, 5, 730, 10.1002/acn3.567 Liu, 2017, Long-term safety of human retinal progenitor cell transplantation in retinitis pigmentosa patients, Stem Cell Res Ther, 8, 209, 10.1186/s13287-017-0661-8 Chen, 2020, NeuroRegen scaffolds combined with autologous bone marrow mononuclear cells for the repair of acute complete spinal cord injury: a 3-year clinical study, Cell Transplant, 29, 10.1177/0963689720950637 Oraee-Yazdani, 2021, Combining cell therapy with human autologous Schwann cell and bone marrow-derived mesenchymal stem cell in patients with subacute complete spinal cord injury: safety considerations and possible outcomes, Stem Cell Res Ther, 12, 445, 10.1186/s13287-021-02515-2 Zamani, 2022, Safety and feasibility of autologous olfactory ensheathing cell and bone marrow mesenchymal stem cell co-transplantation in chronic human spinal cord injury: a clinical trial, Spinal Cord, 60, 63, 10.1038/s41393-021-00687-5 Zhao, 2017, Clinical study of NeuroRegen scaffold combined with human mesenchymal stem cells for the repair of chronic complete spinal cord injury, Cell Transplant, 26, 891, 10.3727/096368917X695038 Xiao, 2018, Significant improvement of acute complete spinal cord injury patients diagnosed by a combined criteria implanted with NeuroRegen scaffolds and mesenchymal stem cells, Cell Transplant, 27, 907, 10.1177/0963689718766279 Tang, 2022, Long-term clinical observation of patients with acute and chronic complete spinal cord injury after transplantation of NeuroRegen scaffold, Sci China Life Sci, 65, 909, 10.1007/s11427-021-1985-5 Liu, 2017, Comparative analysis of curative effect of bone marrow mesenchymal stem cell and bone marrow mononuclear cell transplantation for spastic cerebral palsy, J Transl Med, 15, 48, 10.1186/s12967-017-1149-0 Moviglia, 2018, Local immunomodulation and muscle progenitor cells induce recovery in atrophied muscles in spinal cord injury patients, J Neurorestoratol, 6, 136, 10.26599/JNR.2018.9040011 van Horne, 2018, Peripheral nerve grafts implanted into the substantia nigra in patients with Parkinson's disease during deep brain stimulation surgery: 1-year follow-up study of safety, feasibility, and clinical outcome, J Neurosurg, 129, 1550 Frau, 2018, Long-term follow-up more than 10 years after HSCT: a monocentric experience, J Neurol, 265, 410 Moore, 2019, Prospective phase II clinical trial of autologous haematopoietic stem cell transplant for treatment refractory multiple sclerosis, J Neurol Neurosurg Psychiatry, 90, 514, 10.1136/jnnp-2018-319446 Casanova, 2017, Autologous hematopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: comparison with secondary progressive multiple sclerosis, Neurol Sci, 38, 1213, 10.1007/s10072-017-2933-6 Muraro, 2017, Long-term outcomes after autologous hematopoietic stem cell transplantation for multiple sclerosis, JAMA Neurol, 74, 459, 10.1001/jamaneurol.2016.5867 Burt, 2019, Effect of nonmyeloablative hematopoietic stem cell transplantation vs continued disease-modifying therapy on disease progression in patients with relapsing-remitting multiple sclerosis: a randomized clinical trial, JAMA, 321, 165, 10.1001/jama.2018.18743 Nash, 2017, High-dose immunosuppressive therapy and autologous HCT for relapsing-remitting MS, Neurology, 88, 842, 10.1212/WNL.0000000000003660 Sung, 2018, Intra-carotid arterial transfusion of autologous circulatory derived CD34+ cells for old ischemic stroke patients - a phase I clinical trial to evaluate safety and tolerability, Am J Transl Res, 10, 2975 Chen, 2019, Haploidentical allogenetic hematopoietic stem cell transplantation for X-linked adrenoleukodystrophy (in Chinese), Beijing Da Xue Xue Bao Yi Xue Ban, 51, 409 Goudie, 2019, Hematopoietic stem cell transplant does not prevent neurological deterioration in infants with Farber disease: case report and literature review, JIMD Rep, 46, 46, 10.1002/jmd2.12008 da Cruz, 2018, Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration, Nat Biotechnol, 36, 328, 10.1038/nbt.4114 Kashani, 2018, A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration, Sci Transl Med, 10, 10.1126/scitranslmed.aao4097 Kashani, 2020, Surgical method for implantation of a biosynthetic retinal pigment epithelium monolayer for geographic atrophy: experience from a phase 1/2a study, Ophthalmol Retina, 4, 264, 10.1016/j.oret.2019.09.017 Mandai, 2017, Autologous induced stem-cell-derived retinal cells for macular degeneration, N Engl J Med, 376, 1038, 10.1056/NEJMoa1608368 Takagi, 2019, Evaluation of transplanted autologous induced pluripotent stem cell-derived retinal pigment epithelium in exudative age-related macular degeneration, Ophthalmol Retina, 3, 850, 10.1016/j.oret.2019.04.021 Schweitzer, 2020, Personalized iPSC-derived dopamine progenitor cells for Parkinson's disease, N Engl J Med, 382, 1926, 10.1056/NEJMoa1915872 Sugai, 2021, First-in-human clinical trial of transplantation of iPSC-derived NS/PCs in subacute complete spinal cord injury: study protocol, Regen Ther, 18, 321, 10.1016/j.reth.2021.08.005 Wang, 2017, Safety of neural stem cell transplantation in patients with severe traumatic brain injury, Exp Ther Med, 13, 3613 Steinberg, 2018, Two-year safety and clinical outcomes in chronic ischemic stroke patients after implantation of modified bone marrow-derived mesenchymal stem cells (SB623): a phase 1/2a study, J Neurosurg, 1 Gupta, 2019, Long-term safety, immunologic response, and imaging outcomes following neural stem cell transplantation for pelizaeus-merzbacher disease, Stem Cell Rep, 13, 254, 10.1016/j.stemcr.2019.07.002 Levi, 2018, Emerging safety of intramedullary transplantation of human neural stem cells in chronic cervical and thoracic spinal cord injury, Neurosurgery, 82, 562, 10.1093/neuros/nyx250 Nittala, 2021, Effect of human central nervous system stem cell subretinal transplantation on progression of geographic atrophy secondary to nonneovascular age-related macular degeneration, Ophthalmol Retina, 5, 32, 10.1016/j.oret.2020.06.012 Muir, 2020, Intracerebral implantation of human neural stem cells and motor recovery after stroke: multicentre prospective single-arm study (PISCES-2), J Neurol Neurosurg Psychiatry, 91, 396, 10.1136/jnnp-2019-322515 Zhang, 2019, Stable intracerebral transplantation of neural stem cells for the treatment of paralysis due to ischemic stroke, Stem Cells Transl Med, 8, 999, 10.1002/sctm.18-0220 Curtis, 2018, A first-in-human, phase I study of neural stem cell transplantation for chronic spinal cord injury, Cell Stem Cell, 22, 941, 10.1016/j.stem.2018.05.014 Curt, 2020, The damaged spinal cord is a suitable target for stem cell transplantation, Neurorehabilitation Neural Repair, 34, 758, 10.1177/1545968320935815 Mazzini, 2019, Results from Phase I clinical trial with intraspinal injection of neural stem cells in amyotrophic lateral sclerosis: a long-term outcome, Stem Cells Transl Med, 8, 887, 10.1002/sctm.18-0154 Harris, 2018, Phase I trial of intrathecal mesenchymal stem cell-derived neural progenitors in progressive multiple sclerosis, EBioMedicine, 29, 23, 10.1016/j.ebiom.2018.02.002 Ammar, 2017, A method for reconstruction of severely damaged spinal cord using autologous hematopoietic stem cells and platelet-rich protein as a biological scaffold, Asian J Neurosurg, 12, 681, 10.4103/ajns.AJNS_351_16 Savitz, 2019, A phase 2 randomized, sham-controlled trial of internal carotid artery infusion of autologous bone marrow-derived ALD-401 cells in patients with recent stable ischemic stroke (RECOVER-stroke), Circulation, 139, 192, 10.1161/CIRCULATIONAHA.117.030659 Hess, 2017, Safety and efficacy of multipotent adult progenitor cells in acute ischaemic stroke (MASTERS): a randomised, double-blind, placebo-controlled, phase 2 trial, Lancet Neurol, 16, 360, 10.1016/S1474-4422(17)30046-7 Fang, 2019, Autologous endothelial progenitor cells transplantation for acute ischemic stroke: a 4-year follow-up study, Stem Cells Transl Med, 8, 14, 10.1002/sctm.18-0012 SanBio Co. Ltd Jaillard, 2020, Autologous mesenchymal stem cells improve motor recovery in subacute ischemic stroke: a randomized clinical trial, Transl Stroke Res, 11, 910, 10.1007/s12975-020-00787-z Chung, 2021, Efficacy and safety of intravenous mesenchymal stem cells for ischemic stroke, Neurology, 96, e1012, 10.1212/WNL.0000000000011440 Law, 2021, The effects of intravenous infusion of autologous mesenchymal stromal cells in patients with subacute middle cerebral artery infarct: a phase 2 randomized controlled trial on safety, tolerability and efficacy, Cytotherapy, 23, 833, 10.1016/j.jcyt.2021.03.005 Rah, 2017, Neuroregenerative potential of intravenous G-CSF and autologous peripheral blood stem cells in children with cerebral palsy: a randomized, double-blind, cross-over study, J Transl Med, 15, 16, 10.1186/s12967-017-1120-0 Sun, 2017, Effect of autologous cord blood infusion on motor function and brain connectivity in young children with cerebral palsy: a randomized, placebo-controlled trial, Stem Cells Transl Med, 6, 2071, 10.1002/sctm.17-0102 Levi, 2019, Clinical outcomes from a multi-center study of human neural stem cell transplantation in chronic cervical spinal cord injury, J Neurotrauma, 36, 891, 10.1089/neu.2018.5843 Lublin, 2014, Human placenta-derived cells (PDA-001) for the treatment of adults with multiple sclerosis: a randomized, placebo-controlled, multiple-dose study, Mult Scler Relat Disord, 3, 696, 10.1016/j.msard.2014.08.002 Berry, 2019, NurOwn, phase 2, randomized, clinical trial in patients with ALS, Neurology, 93, e2294, 10.1212/WNL.0000000000008620 Kawabori, 2021, Cell therapy for chronic TBI, Neurology, 96, e1202, 10.1212/WNL.0000000000011450 Min, 2020, Potentiation of cord blood cell therapy with erythropoietin for children with CP: a 2 × 2 factorial randomized placebo-controlled trial, Stem Cell Res Ther, 11, 509, 10.1186/s13287-020-02020-y Amanat, 2021, Clinical and imaging outcomes after intrathecal injection of umbilical cord tissue mesenchymal stem cells in cerebral palsy: a randomized double-blind sham-controlled clinical trial, Stem Cell Res Ther, 12, 439, 10.1186/s13287-021-02513-4 Petrou, 2020, Beneficial effects of autologous mesenchymal stem cell transplantation in active progressive multiple sclerosis, Brain, 143, 3574, 10.1093/brain/awaa333 Petrou, 2021, Long-term clinical and immunological effects of repeated mesenchymal stem cell injections in patients with progressive forms of multiple sclerosis, Front Neurol, 12, 639315, 10.3389/fneur.2021.639315 Huang, 2015, Beijing declaration of international association of neurorestoratology, J Neurorestoratol, 3, 121, 10.2147/JN.S89682 Gobbel, 2010, Cellular transplantation for the nervous system: impact of time after preparation on cell viability and survival, J Neurosurg, 113, 666 Dominici, 2006, Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement, Cytotherapy, 8, 315, 10.1080/14653240600855905 Galipeau, 2016, International Society for Cellular Therapy perspective on immune functional assays for mesenchymal stromal cells as potency release criterion for advanced phase clinical trials, Cytotherapy, 18, 151, 10.1016/j.jcyt.2015.11.008 Kondziolka, 2000, Transplantation of cultured human neuronal cells for patients with stroke, Neurology, 55, 565, 10.1212/WNL.55.4.565 Nelson, 2002, Clonal human (hNT) neuron grafts for stroke therapy: neuropathology in a patient 27 months after implantation, Am J Pathol, 160, 1201, 10.1016/S0002-9440(10)62546-1 Huang, 2009, Olfactory ensheathing cells transplantation for central nervous system diseases in 1,255 patients (in Chinese), Chin J Reparative Reconstr Surg, 23, 14 Huang, 2003, Influence of patients' age on functional recovery after transplantation of olfactory ensheathing cells into injured spinal cord injury, Chin Med J (Engl), 116, 1488 Chen, 2014, A prospective randomized double-blind clinical trial using a combination of olfactory ensheathing cells and schwann cells for the treatment of chronic complete spinal cord injuries, Cell Transplant, 23, 35, 10.3727/096368914X685014 Syková, 2017, Transplantation of mesenchymal stromal cells in patients with amyotrophic lateral sclerosis: results of phase I/IIa clinical trial, Cell Transplant, 26, 647, 10.3727/096368916X693716 Mehta, 2008, Subarachnoid placement of stem cells in neurological disorders, Transplant Proc, 40, 1145, 10.1016/j.transproceed.2008.03.026 Battistella, 2011, Safety of autologous bone marrow mononuclear cell transplantation in patients with nonacute ischemic stroke, Regen Med, 6, 45, 10.2217/rme.10.97 Friedrich, 2012, Intra-arterial infusion of autologous bone marrow mononuclear cells in patients with moderate to severe middle cerebral artery acute ischemic stroke, Cell Transplant, 21, S13, 10.3727/096368912X612512 Moviglia, 2006, Combined protocol of cell therapy for chronic spinal cord injury. Report on the electrical and functional recovery of two patients, Cytotherapy, 8, 202, 10.1080/14653240600736048 Lee, 2010, A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke, Stem Cell, 28, 1099, 10.1002/stem.430 Konomi, 2021, Predictive factors for irreversible motor paralysis following cervical spinal cord injury, Spinal Cord, 59, 554, 10.1038/s41393-020-0513-8 Huang, 2008, Fetal olfactory ensheathing cells transplantation in amyotrophic lateral sclerosis patients: a controlled pilot study, Clin Transplant, 22, 710, 10.1111/j.1399-0012.2008.00865.x Chen, 2010, Intracranial transplant of olfactory ensheathing cells in children and adolescents with cerebral palsy: a randomized controlled clinical trial, Cell Transplant, 19, 185, 10.3727/096368910X492652 Huang, 2020, Clinical neurorestorative therapeutic guidelines for spinal cord injury (IANR/CANR version 2019), J Orthop Transl, 20, 14 El Masri, 2021, Spontaneous neurological recovery of patients with acute traumatic spinal cord injuries (ATSCI) without intervention the injured cord, Int J Orthopedics Rehabil, 8, 19, 10.12974/2313-0954.2021.08.4 Bryukhovetskiy, 2015, Tissue engineering of spinal cord injury in Neurorestoratology, vol. 2, 45 Huang, 2015, vol. 2 Huang, 2009 Siniscalco, 2015, Stem cell transplantation for nervous system disorders in Italy, European Union, and Ukraine: clinical approach and governmental policies, Transl Neurosci Clin, 1, 125, 10.18679/CN11-6030_R.2015.016