Clinical applications of nuclear magnetic resonance (NMR)

Disease-a-Month - Tập 29 - Trang 6-81 - 1983
Ferdinando S Buonanno, Ian L Pykett, Thomas J Brady, Gerald M Pohost

Tài liệu tham khảo

Lauterbur, 1973, Image formation by induced local interactions: Examples employing NMR, Nature, 242, 190, 10.1038/242190a0 Lauterbur, 1974, Magnetic resonance zeugmatography, Pure Appl. Chem., 40, 149, 10.1351/pac197440010149 Mansfield, 1976, Planar and line-scan spin imaging by NMR, 247 Mansfield, 1977, Medical imaging by NMR, Br. J. Radiol., 60, 188, 10.1259/0007-1285-50-591-188 1978, New Scientist, 80, 588 1981, 5, 285 Holland, 1981, NMR tomography by projection reconstruction: Methods, system technology, and results, J. Comput. Assist. Tomogr., 5, 288, 10.1097/00004728-198104000-00033 Edelstein, 1981, A whole-body nuclear magnetic resonance imaging machine, J. Comput. Assist. Tomogr., 5, 292, 10.1097/00004728-198104000-00037 1982 Gordon, 1980, Localization of metabolites in animals using 31P topical magnetic resonance, Nature, 287, 736, 10.1038/287736a0 Abragam, 1961 Slichter, 1980 Farrar, 1971 Pykett, 1982, Principles of nuclear magnetic resonance imaging, Radiology, 143, 157, 10.1148/radiology.143.1.7038763 Pykett, 1983, Techniques and approaches to proton NMR imaging of the head, Comput. Radiol., 7, 1, 10.1016/0730-4862(83)90169-5 Brunner, 1979, Sensitivity and performance time in NMR imaging, J. Magnet. Res., 33, 83 Lai, 1981, True three-dimensional image reconstruction by nuclear magnetic resonance zeugmatography, Phys. Med. Biol., 26, 851, 10.1088/0031-9155/26/5/004 Pykett I.L., Kistler J.P., Buonanno F.S., et al.: True three-dimensional NMR neuro-imaging in ischemic stroke: Correlation of NMR, X-ray CT and pathology, unpublished manuscript. Mallard, 1980, In-vivo NMR imaging in medicine: The Aberdeen approach, both physical and biological, Philos. trans. R. Soc. Lond. [Biol.], B289, 519, 10.1098/rstb.1980.0071 Pykett, 1978, A line scan image study of a tumorous rat leg by NMR, Phys. Med. Biol., 23, 961, 10.1088/0031-9155/23/5/012 Pykett I.L., Buonanno F.S., Brady T.J.: Measurement of spin-lattice relaxation times in nuclear magnetic resonance imaging. Phys. Med. Biol., to be published. Singer, 1981, Blood flow measurements by NMR, 128 Budinger, 1979, Thresholds for physiological effects due to RF and magnetic fields used in NMR imaging, IEEE Trans. Nucl. Sci., NS-26, 2821, 10.1109/TNS.1979.4330543 Thomas, 1981, The effects of NMR exposure on living organisms: I. A microbial assay, Br. J. Radiol., 54, 615, 10.1259/0007-1285-54-643-615 Cooke, 1981, The effects of NMR exposure on living organisms: II. A genetic study of human lymphocytes, Br. J. Radiol., 54, 622, 10.1259/0007-1285-54-643-622 Wolff, 1980, Tests for DNA and chromosomal damage induced by nuclear magnetic resonance imaging, Radiology, 136, 707, 10.1148/radiology.136.3.7403551 1981, Radiography, 47, 258 Fung, 1972, Correlation of relaxation time with water content in muscle and brain tissues, Biochim. Biophys. Acta, 497, 317, 10.1016/0304-4165(77)90165-9 Chang, 1976, The spin lattice relaxation times of water associated with early postmortem changes in skeletal muscle, Biochim. Biophys. Acta, 437, 253, 10.1016/0304-4165(76)90367-6 Hazlewood, 1971, On the state of water in developing muscle: A study of the major phase of ordered water in skeletal muscle and its relationship to sodium concentration, Johns Hopkins Med. J., 128, 117 Belton, 1974, Pulsed NMR studies of water in striated muscle: IV. The effects of water content, Biochim. Biophys. Acta, 354, 305, 10.1016/0304-4165(74)90015-4 Cooke, 1971, The state of water in muscle tissue as determined by proton nuclear magnetic resonance, Biophys. J., 11, 1002, 10.1016/S0006-3495(71)86274-4 Bratton, 1965, Nuclear magnetic resonance studies of living muscle, Science, 197, 738, 10.1126/science.147.3659.738 Buonanno F.S., Pykett I.L., Brady T.J., et al.: Proton NMR imaging in experimental ischemic infarction. Stroke, to be published. Kahn, 1972, The natural course of experimental cerebral infarction in the gerbil, Neurology (Minneap.), 22, 510, 10.1212/WNL.22.5.510 Levine, 1966, Effects of ischemic and other procedures on the brain and retina of the gerbil, Exp. Neurol., 16, 255, 10.1016/0014-4886(66)90062-8 Wexler, 1972, Pathophysiological responses to acute cerebral ischemia in the gerbil, Stroke, 3, 77, 10.1161/01.STR.3.1.71 Yanagihara, 1978, Experimental stroke in gerbils: Correlation of clinical, pathological and electroencephalographic findings and protein synthesis, Stroke, 9, 155, 10.1161/01.STR.9.2.155 Go, 1978, Water in brain edema: Observations by the pulsed nuclear magnetic resonance technique, Arch. Neurol., 32, 462, 10.1001/archneur.1975.00490490066006 Cottam, 1974, The gelatin of deoxyhemoglobin 5 in erythrocytes as detected by transverse water proton relaxation measurements, Arch. Biochem. Biophys., 162, 487, 10.1016/0003-9861(74)90208-2 Thompson, 1975, Evaluation of the water environments in deoxygenated sickle cells by longitudinal and transverse water proton relaxation rates, Arch. Biochem. Biophys., 166, 193, 10.1016/0003-9861(75)90380-X Xipp, 1976, Water proton magnetic resonance studies of normal and sickle erythrocytes: Temperature and volume dependence, Biochim. Biophys. Acta, 427, 291 Doyle, 1981, Relaxation rate enhancement observed in vivo by NMR imaging, J. Comput. Assist. Tomogr., 5, 295, 10.1097/00004728-198104000-00041 Brownstein, 1979, Importance of chemical diffusion in NMR studies of water in biological cells, Physiol. Rev. A., 19, 2446, 10.1103/PhysRevA.19.2446 Hansen, 1971, Pulsed NMR study of water mobility in muscle and brain fibers, Biochim. Biophys. Acta, 230, 482, 10.1016/0304-4165(71)90177-2 Chang, 1972, Spin-echo studies on cellular water, Nature, 235, 170, 10.1038/235170a0 Hazlewood, 1974, Nuclear magnetic resonance transverse relaxation times of water protons in skeletal muscle, Biophys. J., 14, 583, 10.1016/S0006-3495(74)85937-0 Edzes, 1978, The measurement of cross-relaxation effects in the proton NMR spin-lattice relaxation of water in biological systems: Hydrated collagen and muscle, J. Magnet. Res., 31, 207 Fung, 1979, Study of spin-lattice and spin-spin relaxation times of 1H, 2H and 17O in muscle water, Biophys. J., 28, 293, 10.1016/S0006-3495(79)85177-2 Blicharaska, 1970, Investigation of protein-hydration by proton spin relaxation time measurements, Biochim. Biophys. Acta, 207, 381, 10.1016/S0005-2795(70)80001-0 1981 1981 Mathur-DeVre, 1979, The NMR studies of water in biological systems, Prog. Biophys. Mol. Biol., 35, 103, 10.1016/0079-6107(80)90004-8 Gutowsky, 1954, Nuclear magnetic resonance, Annu. Rev. Phys. Chem., 5, 333, 10.1146/annurev.pc.05.100154.002001 Meiboom, 1963, Nuclear magnetic resonance, Annu. Rev. Phys. Chem., 14, 335, 10.1146/annurev.pc.14.100163.002003 Grant, 1964, High resolution nuclear magnetic resonance, Annu. Rev. Phys. Chem., 15, 489, 10.1146/annurev.pc.15.100164.002421 Jonas, 1968, Nuclear magnetic resonance, Annu. Rev. Phys. Chem., 19, 447, 10.1146/annurev.pc.19.100168.002311 Jonas, 1980, NMR in chemistry: An evergreen, Annu. Rev. Phys. Chem., 31, 1, 10.1146/annurev.pc.31.100180.000245 Bersohn, 1960, Nuclear and electron resonance, Annu. Rev. Phys. Chem., 11, 369, 10.1146/annurev.pc.11.100160.002101 Shulman, 1962, Electron and nuclear spin resonance, Annu. Rev. Phys. Chem., 13, 325, 10.1146/annurev.pc.13.100162.001545 Cohn, 1978, Nuclear magnetic resonance studies of protein-nucleotid interactions, 191 Brown, 1981, In vivo enzyme kinetics using magnetization transfer NMR, J. Comput. Assist. Tomogr., 5, 301, 10.1097/00004728-198104000-00047 Cohn, 1960, Phosphorus magnetic resonance spectra of adenosine di- and triphosphate: I. Effect of pH, J. Biol. Chem., 235, 3250, 10.1016/S0021-9258(20)81346-5 Burt, 1979, An analysis of intact tissue by means of 31P magnetic resonance, Annu. Rev. Biophys. Bioeng., 8, 1, 10.1146/annurev.bb.08.060179.000245 Scott, 1981, Phosphorous nuclear magnetic resonance: Potential application to diagnostic chemistry, J. Comput. Assist. Tomogr., 5, 302, 10.1097/00004728-198104000-00049 Shulman, 1979, Cellular applications of 31P and 13C nuclear magnetic resonance, Science, 205, 160, 10.1126/science.36664 Hollis, 1980, Phosphorus NMR of cells, tissues and organelles, volume 2, 1 Hollis, 1978, Phosphorus nuclear magnetic resonance studies of heart physiology, J. Magnet. Res., 29, 319 Nunnally, 1981, 31P NMR studies of myocardial ischemia and its response to drug therapies, J. Comput. Assist. Tomogr., 5, 296, 10.1097/00004728-198104000-00042 Nunnally, 1981, Assessment of pharmacological treatment of myocardial infarction by phosphorus-31 NMR with surface coils, Science, 211, 177, 10.1126/science.7444460 Chance, 1978, Detection of 31P nuclear magnetic resonance signals in brain by in vivo and freeze-frapped assays, 75, 4925 Ackerman, 1980, Mapping of metabolites in whole animals by 31P NMR using surface coils, Nature, 283, 167, 10.1038/283167a0 Chance, 1981, Inorganic phosphate levels as indicators of incipient hypoxia: Correlations with mitochondrial functions, J. Comput. Assist. Tomogr., 5, 295, 10.1097/00004728-198104000-00040 Shaw, 1981, Localization of metabolites in animals and human tissues using 31P NMR: Topical magnetic resonance (TMR), J. Comput. Assist. Tomogr., 5, 299, 10.1097/00004728-198104000-00044 Ross, 1981, Examination of a case of suspected McArdle's syndrome by 31P nuclear magnetic resonance, N. Engl. J. Med., 304, 1338, 10.1056/NEJM198105283042206 Edwards, 1982, Clinical use of nuclear magnetic resonance in the investigation of myopathy, Lancet, 1, 725, 10.1016/S0140-6736(82)92635-6 Allerhand, 1970, Nuclear magnetic resonance, Annu. Rev. Phys. Chem., 21, 317, 10.1146/annurev.pc.21.100170.001533 Allerhand, 1978, Natural abundance C-13 nuclear magnetic resonance spectroscopy of proteins: Observation and uses of non-protonated aromatic carbon resonances, Acc. Chem. Res., 11, 469, 10.1021/ar50132a006 Bocian, 1978, NMR studies of membrane structure and dynamics, Annu. Rev. Phys. Chem., 29, 307, 10.1146/annurev.pc.29.100178.001515 Jacobs, 1981, NMR of membranes, Prog. Nucl. Magnet. Res. Spectrosc., 14, 113, 10.1016/0079-6565(80)80006-9 Wyrwicz, 1982, Multinuclear NMR studies of blood in a flowing system, 149 Burt, 1982, 19F NMR examination of the binding of halothane to erythrocytes, serum and whole blood, J. Magnet. Res. Med., 1, 35 Barany, 1977, Application of 31P NMR for the study of diseased muscle, 337 Chalovich, 1977, The identification of an unknown 31P NMR resonance from dystrophic chicken at l-serine ethanolamine phosphodiester, Arch. Biochem. Biophys., 182, 683, 10.1016/0003-9861(77)90549-5 Burt, 1978, Phosphorous nuclear magnetic resonance of diseased muscle, Frontiers Biol. Energetics, 2, 1371, 10.1016/B978-0-12-225402-4.50074-7 Stengle, 1966, Halide ions as chemical probes for NMR studies of proteins, 55, 1020 Bryant, 1978, NMR relaxation studies of solute-solvent interactions, Annu. Rev. Phys. Chem., 29, 167, 10.1146/annurev.pc.29.100178.001123 Shulman, 1961, Ferromagnetic resonance in DNA samples, Biochem. Biophys. Res. Commun., 5, 52, 10.1016/0006-291X(61)90079-1 Cohn, 1962, Nuclear magnetic resonance spectra of adenosine di- and triphosphate: II. Effects of complexing with divalent metal ions, J. Biol. Chem., 237, 176, 10.1016/S0021-9258(18)81382-5 Damadian, 1971, Tumor detection by nuclear magnetic resonance, Science, 171, 1151, 10.1126/science.171.3976.1151 Hollis, 1972, A nuclear magnetic resonance study of water in two Morris hepatomas, Johns Hopkins Med. J., 131, 441 Hazlewood, 1972, Distinction between the preneoplastic and neoplastic state of murine mammary glands, 50, 1478 Hollis, 1973, Nuclear magnetic resonance studies of several experimental and human malignant tumors, Cancer Res., 33, 2156 Saryan, 1974, Nuclear magnetic resonance studies of cancer: IV. Correlation of water content with tissue relaxation times, JNCI, 52, 599, 10.1093/jnci/52.2.599 Goldsmith, 1978, NMR in cancer: XIII. Application of the NMR malignancy index to human mammary tumours, Br. J. Cancer, 38, 547, 10.1038/bjc.1978.243 Bovee, 1980, NMR relaxation and images of human breast tumors in vitro, Philos. Trans. R. Soc. London, 289, 535, 10.1098/rstb.1980.0072 Inch, 1974, Water content and proton spin relaxation time for neoplastic and non-neoplastic tissues from mice and humans, JNCI, 52, 353, 10.1093/jnci/52.2.353 Szent-Gyorgyi, 1957 Ling, 1965, The physical state of water in living cell and model systems, Ann. NY Acad. Sci., 125, 401, 10.1111/j.1749-6632.1965.tb45406.x Ling, 1978, Experimental confirmation, from model studies, of a key prediction of the polarized multilayer theory of cell water, Physiol. Chem. Phys., 10, 87 Belton, 1972, Pulsed NMR studies of water in striated muscle: I. Transverse nuclear spin relaxation times and freezing effects, Biochim. Biophys. Acta, 286, 16, 10.1016/0304-4165(72)90084-0 Kiricuta, 1973, State of water in normal and tumor tissues, Arch. Geschwulstforsch., 42, 226 Fung, 1975, The state of water in biological systems as studied by proton and deuterium relaxation, Biochim. Biophys. Acta, 399, 191, 10.1016/0304-4165(75)90225-1 Block, 1974, Proton magnetic resonance studies of water in normal and tumor rat tissues, J. Magnet. Res., 14, 329 Eggleston, 1978, Nuclear magnetic resonance investigation of human neoplastic and abnormal nonneoplastic tissues, Cancer Res., 35, 1326 Kasturi, 1976, Tissue hydration of malignant and uninvolved human tissues and its relevance to proton spin-lattice relaxation mechanism, 84, 60 Kagimoto, 1977, Nuclear magnetic resonance study of human bone marrows from patients with leukemia, anemia, and myeloma and from normal donors, JNCI, 59, 335, 10.1093/jnci/59.2.335 Beall, 1976, Nuclear magnetic resonance patterns of intracellular water as a function of HeLa cell cycle, Science, 192, 904, 10.1126/science.1273575 Beall, 1980, Distribution of normal, preneoplastic, and neoplastic mouse mammary primary cell cultures by water nuclear magnetic resonance relaxation times, JNCI, 64 Ling, 1980, Nuclear magnetic resonance relaxation and water content in normal mouse and rat tissues and in cancer cells, JNCI, 64, 1199 Fossel, 1982, Physiologic studies Lauterbur, 1976, In-vivo zeugmatographic imaging of tumours, Physics in Canada, 32, 11 Bottomley, 1979, In vivo tumor discrimination in a rat by proton nuclear magnetic resonance imaging, Cancer Res., 39, 468 Smith, 1981, Oesophageal carcinoma demonstrated by whole body nuclear magnetic resonance imaging, Br. Med. J., 282, 510, 10.1136/bmj.282.6263.510 Smith, 1981, Nuclear magnetic resonance tomographic imaging in liver disease, Lancet, 1, 963, 10.1016/S0140-6736(81)91731-1 Doyle, 1981, Imaging of the brain by nuclear magnetic resonance, Lancet, 2, 53, 10.1016/S0140-6736(81)90408-6 Doyle, 1982, Nuclear magnetic resonance imaging of the liver: Initial experience, AJR, 138, 193, 10.2214/ajr.138.2.193 Buonanno, 1982, Clinical relevance of two different nuclear magnetic resonance (NMR) approaches to imaging of a low grade astrocytoma, J. Comput. Assist. Tomogr., 6, 529, 10.1097/00004728-198206000-00018 Bydder, 1982, Clinical NMR imaging of the brain: 140 cases, AJR, 139, 215, 10.2214/ajr.139.2.215 Brady, 1982, NMR imaging of forearms in healthy volunteers and patients with giant cell tumor of bone, Radiology, 144, 549, 10.1148/radiology.144.3.7100470 Herfkens, 1981, Nuclear magnetic resonance imaging of the abnormal live rat and correlations with tissue characteristics, Radiology, 141, 211, 10.1148/radiology.141.1.7197379 Bakkar, 1982, In-vitro relaxation monitoring of tissue response to radiotherapy Gordon, 1982, Topical magnetic resonance, Prog. NMR Spectroscopy, 15, 1, 10.1016/0079-6565(82)80007-1 Garlick, 1979, Studies of acidosis in the ischemic heart by phosphorus nuclear magnetic resonance, Biochem. J., 184, 547, 10.1042/bj1840547 Gadian, 1976, Phosphorus nuclear magnetic resonance studies on mormoxic and ischemic cardiac tissue, 73, 4446 Moon, 1973, Determination of intracellular pH by 31P magnetic resonance, J. Biol. Chem., 248, 7276, 10.1016/S0021-9258(19)43389-9 Maoon, 1978, Phosphate metabolites in lymphoid, Friend erythroleukemia and HeLa cells observed by high-resolution 31P nuclear magnetic resonance, 75, 891 Griffin, 1981, Topical magnetic resonance studies of tumors Labotka, 1976, Phosphorous-31 spectroscopic determination of the phosphorous metabolite profile of blood components: Erythrocytes, reticulocytes and platelets, Biochem. Med., 15, 311, 10.1016/0006-2944(76)90063-6 Burt, 1982, Phosphodiester changes associated with electrically stimulated rabbit muscle, Biophys. J., 37, 128A Warburg, 1930, On the metabolism of tumors in the body, 15 Warburg, 1930, On the metabolism of tumors in the body, 254 Brady T.J., Burt C.T., Goldman M.R., et al.: Tumor characterization using 31-P NMR spectroscopy. To be published. Ng, 1982, In-vivo 31P NMR studies of tumor metabolism and the effects of cancer therapy Hutchison, 1977, Imaging by nuclear magnetic resonance, 135 Hansen, 1980, In-vivo imaging of rat anatomy with nuclear magnetic resonance, Radiology, 136, 695, 10.1148/radiology.136.3.7403549 Hinshaw, 1978, Display of cross sectional anatomy by nuclear magnetic resonance imaging, Br. J. Radiol., 51, 273, 10.1259/0007-1285-51-604-273 Buonanno, 1982, Cranial anatomy and detection of ischemic stroke in the cat by nuclear magnetic resonance imaging, Radiology, 143, 183, 10.1148/radiology.143.1.7063725 Chesler, 1975, Ripple suppression during reconstruction in transverse tomography, Phys. Med. Biol., 20, 632, 10.1088/0031-9155/20/4/011 Lauterbur, 1981, NMR zeugmatographic imaging by true three-dimensional reconstruction, J. Comput. Assist. Tomogr., 5, 285 Edelstein, 1980, Spin-warp NMR imaging and applications to human whole-body imaging, Phys. Med. Biol., 25, 751, 10.1088/0031-9155/25/4/017 Holland, 1980, Nuclear magnetic resonance tomography of the brain: Coronal and sagittal sections, J. Comput. Tomogr., 4, 429, 10.1097/00004728-198008000-00002 Buonanno, 1982, Proton NMR imaging of normal and abnormal brain: Experimental and clinical observations, 147 Buonanno F.S., Pykett I.L., Kistler J.P., et al.: Proton (1H) NMR imaging in cerebral infarction, in Lechner et al. (eds.): Cerebral Vascular Diseases. Amsterdam, Elsevier Publishers, to be published. Hawkes, 1980, Nuclear magnetic resonance (NMR) tomography of the brain: A preliminary clinical assessment with demonstration of pathology, J. Comput. Assist. Tomogr., 4, 577, 10.1097/00004728-198010000-00001 Young, 1982, Initial clinical evaluation of a whole body tomograph, J. Comput. Assist. Tomogr., 6, 1, 10.1097/00004728-198202000-00001 Bailes, 1982, NMR imaging of the brain using spin-echo sequences, Clin. Radiol., 33, 395, 10.1016/S0009-9260(82)80307-3 Sears, 1982, Maximizing the harvest of contrast enhancing lesions in multiple sclerosis, Neurology, 32, 815, 10.1212/WNL.32.8.815 Buonanno, 1982, NMR imaging in patients with multiple sclerosis: Potential of in-vivo lesion characterization using T1 NMR imaging, Neurology, 32, A163 Young, 1981, Nuclear magnetic resonance imaging of the brain in multiple sclerosis, Lancet, 2, 1063, 10.1016/S0140-6736(81)91273-3 Lukes, 1982, Nuclear magnetic resonance imaging in patients with definite multiple sclerosis, Ann. Neurol., 12, 76 Kistler, 1982, Clinical experience using nuclear magnetic resonance (NMR) imaging in cerebral vascular and other CNS diseases: Comparison with X-ray CT and pathology, Neurology, 32, A88 Bracy, 1982, Proton NMR imaging of intracranial neoplasms: In-vivo measurement of T1 and mobile proton density, Neurology, 32, A155 Lukes, 1982, Comparison of nuclear magnetic resonance and computed tomographic findings in patients with extrapyramidal movement disorders, Ann. Neurol., 12, 88 Buonanno, 1982, Proton nuclear magnetic resonance imaging of human brain, Ann. Neurol., 12, 89 Pettegrew, 1982, Phosphorus 31 nuclear magnetic resonance analysis of Huntington and control brain, Ann. Neurol., 12, 91 Damadian, 1977, NMR in cancer: XVI. FONAR image of the live human body, Physiol. Chem. Phys., 9, 97 Damadian, 1976, Tumor imaging in a live animal by Field Focussing NMR (FONAR), Physiol. Chem. Phys., 8, 61 Hawkes, 1981, Nuclear magnetic resonance (NMR) tomography of the normal heart, J. Comput. Assist Tomogr., 5, 605, 10.1097/00004728-198110000-00001 Alfidi, 1982, Preliminary experimental results in humans and animals with a superconducting, whole body nuclear magnetic resonance scanner, Radiology, 143, 175, 10.1148/radiology.143.1.7063723 Ordidge, 1982, Real time moving images by NMR, 89 Mansfield, 1982, Real time dynamic imaging by NMR, 94 Mansfield, 1978, Biological and medical imaging by NMR, J. Magnet. Res., 29, 355 Powell, 1976, Effects of hyperosmotic mannitol in reducing ischemic cell swelling and minimizing myocardial necrosis, Circulation, 53, 145 Powell, 1977, Detection of edema associated with myocardial ischemia by computerized tomography in isolated, arrested canine heart, Circulation, 55, 99, 10.1161/01.CIR.55.1.99 Williams, 1980, Prolongation of proton spin lattice relaxation times in regionally ischemic tissue from dog hearts, J. Nucl. Med., 21, 449 Katz, 1981, Lipid-membrane interactions and the pathogenesis of ischemic damage in the myocardium, Circ. Res., 48, 1, 10.1161/01.RES.48.1.1 Chauncey, 1977, Tissue distribution studies with radioactive manganese: A potential agent for cardiac imaging, J. Nucl. Med., 18, 933 Lauterbur, 1980, Augmentation of tissue water proton relaxation rates by in vivo addition of paramagnetic ions, 752 Brady, 1982, Proton nuclear magnetic resonance imaging of regionally ischemic canine hearts: Effect of paramagnetic proton signal enhancement, Radiology, 144, 343, 10.1148/radiology.144.2.6283594 Goldman M.R., Brady T.J., Pykett I.L., et al.: Quantification of experimental myocardial infarction using nuclear magnetic resonance imaging with paramagnetic ion contrast enhancement in excised canine hearts. Circulation, to be published. DeLayre, 1981, Gated sodium-23 nuclear magnetic resonance images of an isolated perfused working cat heart, Science, 212, 935, 10.1126/science.7233188 Nunnally, 1982, In-vivo and in-situ metabolic evaluations by C-13 and P-31 NMR, 119 Hinshaw, 1977, Radiographic thin section imaging of a human wrist by nuclear magnetic resonance, Nature, 270, 722, 10.1038/270722a0 Hinshaw, 1979, An in-vivo study of the forearm and hand by thin section NMR imaging, Br. J. Radiol., 52, 36, 10.1259/0007-1285-52-613-36 Smith, 1982, Clinical imaging at Aberdeen, 145 Mansfield, 1978, Human whole-body live-scan imaging by NMR, Br. J. Radiol., 51, 921, 10.1259/0007-1285-51-611-921 Bydder, 1982, NMR: Initial clinical results, 107 Hakwes, 1982, Preliminary assessment of the clinical potential of NMR imaging, 115 Smith, 1982, Clinical application of NMR tomographic imaging, 125 Ross, 1982, Nuclear magnetic resonance imaging and evaluation of human breast tissue: Preliminary clinical trials, Radiology, 143, 195, 10.1148/radiology.143.1.7063727 Newhouse, 1982, NMR scanning of the abdomen: preliminary results in small animals, 121 Davis, 1981, NMR Characteristics of normal and abnormal rat tissues