Clinical and echographic analysis of photodynamic therapy using methylaminolevulinate as sensitizer in the treatment of photodamaged facial skin

Lasers in Surgery and Medicine - Tập 39 Số 3 - Trang 203-209 - 2007
Cristina Zane1, Rossana Capezzera2, Raffaella Sala2, Marina Venturini2, Piergiacomo Calzavara‐Pinton2
1Department of Dermatology, Spedali Civili Hospital, University of Brescia, Brescia, Italy.
2Department of Dermatology, Spedali Civili Hospital and University of Brescia, Brescia, Italy

Tóm tắt

AbstractBackground and Objective

Photodynamic therapy (PDT) using aminolevulinic acid (ALA) has been previously investigated in the treatment of photodamaged skin. The aim was to assess efficacy and tolerability of methylaminolevulinate (MAL) as a substitute for ALA in PDT treatment of actinic keratosis (AK) and photoaging.

Study Design/Materials and Methods

Twenty patients with multiple (n = 137) AKs and severe photodamage of the face were treated. Metvix® (Galderma, France) was applied under occlusion for 3 hours before exposure to 37 J/cm2 of red light (Aklilite® CL 128, Photocure, Norway). Two treatments were given at monthly intervals.

Results

The clearance rate of AKs was 88.3%, and global score which we use to rate photoaging, mottled hyperpigmentation, fine lines, roughness, and sallowness of the skin showed improvement, but deep wrinkles, teleangiectasia, facial erythema, and sebaceous gland hypertrophy did not change. The treatments were well tolerated. High‐resolution echography showed an increase in skin thickness, pixels count and area, as well as a reduction of the subepidermal low‐echogenic band (SLEB) thickness.

Conclusion

MAL‐PDT is an effective treatment for multiple AKs. In addition, it improves clinical signs of photodamage of the surrounding skin. Lasers Surg. Med. 39:203–209, 2007. © 2007 Wiley‐Liss, Inc.

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Lasers in Surgery and Medicine

Tập 39 Số 3

203-209

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