Clinical and Immunologic Evaluation of Dendritic Cell–Based Immunotherapy in Combination With Gemcitabine and/or S-1 in Patients With Advanced Pancreatic Carcinoma

Pancreas - Tập 41 Số 2 - Trang 195-205 - 2012
Yukino Kimura1, Jun Tsukada2,1, Takeshi Tomoda3, Hidenori Takahashi3, Kazuhiro Imai1, Kanae Shimamura1, Makoto Sunamura4, Yoshikazu Yonemitsu5, Shigetaka Shimodaira6, Shigeo Koido7, Sadamu Homma1,3, Masato Okamoto2,1,3
1Research and Development Division, Tella Inc, Tokyo
2Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo
3Seren Clinic, Tokyo
4Department of Molecular Pathology, Tohoku University School of Medicine, Sendai
5R&D Laboratory for Innovative Biotherapeutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka
6Cell Processing Center, Shinshu University Hospital, Nagano
7Division of Gastroenterology and Hepatology, Department of Internal Medicine and **Department of Oncology, Institute of DNA Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Tóm tắt

Từ khóa


Tài liệu tham khảo

Jemal, 2007, Cancer statistics, 2007, Cancer J Clin, 57, 43, 10.3322/canjclin.57.1.43

Sener, 1999, Pancreatic cancer: a report of treatment and survival trends for 100,313 patients diagnosed from 1985–1995, using the national cancer database, J Am Coll Surg, 189, 1, 10.1016/S1072-7515(99)00075-7

Neoptolemos, 2004, A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer, N Engl J Med, 350, 1200, 10.1056/NEJMoa032295

Burris, 1997, Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial, J Clin Oncol, 15, 2403, 10.1200/JCO.1997.15.6.2403

Okusaka, 2008, A late phase II study of S-1 for metastatic pancreatic cancer, Cancer Chemother Pharmacol, 61, 615, 10.1007/s00280-007-0514-8

Nakai, 2010, Impact of S-1 in patients with gemcitabine-refractory pancreatic cancer in Japan, Jpn J Clin Oncol, 40, 774, 10.1093/jjco/hyq059

Sugiyama, 2005, Cancer immunotherapy targeting Wilms’ tumor gene wt1 product, Expert Rev Vaccines, 4, 503, 10.1586/14760584.4.4.503

Mukherjee, 2000, Mice with spontaneous pancreatic cancer naturally develop MUC-1–specific CTLs that eradicate tumors when adoptively transferred, J Immunol, 165, 3451, 10.4049/jimmunol.165.6.3451

Nair, 1999, Induction of carcinoembryonic antigen (CEA)–specific cytotoxic T-lymphocyte responses in vitro using autologous dendritic cells loaded with CEA peptide or CEA RNA in patients with metastatic malignancies expressing CEA, Int J Cancer, 82, 121, 10.1002/(SICI)1097-0215(19990702)82:1<121::AID-IJC20>3.0.CO;2-X

Larbouret, 2007, In vivo therapeutic synergism of anti–epidermal growth factor receptor and anti-Her2 monoclonal antibodies against pancreatic carcinomas, Clin Cancer Res, 1, 3356, 10.1158/1078-0432.CCR-06-2302

Gjertsen, 1995, Vaccination with mutant ras peptides and induction of T-cell responsiveness in pancreatic carcinoma patients carrying the corresponding ras mutation, Lancet, 346, 1399, 10.1016/S0140-6736(95)92408-6

Hoffmann, 2000, Generation of T cells specific for the wild-type sequence p53 (264–272) peptide in cancer patients: implications for immunoselection of epitope loss variants, J Immunol, 165, 5938, 10.4049/jimmunol.165.10.5938

Inaba, 1994, The tissue distribution of the b7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro, J Exp Med, 180, 1849, 10.1084/jem.180.5.1849

Mayordomo, 1995, Bone marrow–derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity., Nat Med, 1, 1297, 10.1038/nm1295-1297

Thurner, 1999, Vaccination with MAGE-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma, J Exp Med, 190, 1669, 10.1084/jem.190.11.1669

Cheever, 2009, The prioritization of cancer antigens: a National Cancer Institute pilot project for the acceleration of translational research, Clin Cancer Res, 15, 5323, 10.1158/1078-0432.CCR-09-0737

Oka, 2004, Induction of wt1 (Wilms’ tumor gene)-specific cytotoxic T lymphocytes by wt1 peptide vaccine and the resultant cancer regression, Proc Natl Acad Sci U S A, 101, 13885, 10.1073/pnas.0405884101

Oka, 2006, Development of wt1 peptide cancer vaccine against hematopoietic malignancies and solid cancers, Curr Med Chem, 13, 2345, 10.2174/092986706777935104

Ramanathan, 2005, Phase I study of a MUC1 vaccine composed of different doses of MUC1 peptide with SB-AS2 adjuvant in resected and locally advanced pancreatic cancer, Cancer Immunol Immunother, 54, 254, 10.1007/s00262-004-0581-1

Plate, 2005, Effect of gemcitabine on immune cells in subjects with adenocarcinoma of the pancreas, Cancer Immunol Immunother, 54, 915, 10.1007/s00262-004-0638-1

Soeda, 2009, Regular dose of gemcitabine induces an increase in CD14+ monocytes and CD11c+ dendritic cells in patients with advanced pancreatic cancer, Jpn J Clin Oncol, 39, 797, 10.1093/jjco/hyp112

Okamoto, 1998, cis-Diamminedichloroplatinum and 5-fluorouracil are potent inducers of the cytokines and natural killer cell activity in vivo and in vitro, Cancer Immunol Immunother, 47, 233, 10.1007/s002620050526

Okamoto, 2000, Induction of cytokines and killer cell activities by cisplatin and 5-fluorouracil in head and neck cancer patients, Anticancer Drugs, 11, 165, 10.1097/00001813-200003000-00004

Böyum, 1967, Isolation of mononuclear cells and granulocytes from human blood, Scand J Clin Invest, 21, 77

Okamoto, 2004, Expression of Toll-like receptor 4 on dendritic cells is significant for anti-cancer effect of dendritic cell–based immunotherapy in combination with an active component of OK-432, a streptococcal preparation, Cancer Res, 64, 5461, 10.1158/0008-5472.CAN-03-4005

Okamoto, 2003, Involvement of Toll-like receptor 4 signaling in interferon-γ production and anti-tumor effect by a streptococcal agent OK-432, J Natl Cancer Inst, 95, 316, 10.1093/jnci/95.4.316

Ahmed, 2004, Anti-tumor effect of an intratumoral administration of dendritic cells in combination with TS-1, an oral fluoropyrimidine anti-cancer drug, and OK-432, a streptococcal immunopotentiator: involvement of Toll-like receptor 4, J Immunother, 27, 432, 10.1097/00002371-200411000-00003

Okamoto, 2006, Mechanism of anti-cancer host response induced by OK-432, a streptococcal preparation, mediated by phagocytosis and Toll-like receptor 4 signaling, J Immunother, 29, 78, 10.1097/01.cji.0000192106.32206.30

Oshikawa, 2006, Anti-tumor effect of OK-432–derived DNA: one of the active constituents of OK-432, a streptococcal immunotherapeutic agent, J Immunother, 29, 143, 10.1097/01.cji.0000189028.18288.6f

Nakahara, 2003, Dendritic cells stimulated with a bacterial product, OK-432, efficiently induce cytotoxic T lymphocytes specific to tumor rejection peptide, Cancer Res, 63, 4112

Itoh, 2003, Streptococcal preparation OK432 promotes functional maturation of human monocyte–derived dendritic cells, Cancer Immunol Immunother, 52, 207, 10.1007/s00262-002-0337-8

Sato, 2003, Generation of mature dendritic cells fully capable of T helper type 1 polarization using OK-432 combined with prostaglandin E(2), Cancer Sci, 94, 1091, 10.1111/j.1349-7006.2003.tb01405.x

Kontani, 2002, Novel vaccination protocol consisting of injecting MUC1 DNA and nonprimed dendritic cells at the same region greatly enhanced MUC1-specific antitumor immunity in a murine model, Cancer Gene Ther, 9, 330, 10.1038/sj.cgt.7700444

Cannon, 2004, Immunological treatment of ovarian cancer, Curr Opin Obstet Gynecol, 16, 87, 10.1097/00001703-200402000-00015

Nagayama, 2003, Results of a phase I clinical study using autologous tumour lysate–pulsed monocyte-derived mature dendritic cell vaccinations for stage IV malignant melanoma patients combined with low dose interleukin-2, Melanoma Res, 13, 521, 10.1097/00008390-200310000-00011

Chong, 1994, ICAM-1 and LFA-3 enhance the ability of anti-CD3 mAb to stimulate interferon gamma production in interleukin-2–activated T cells, Cancer Immunol Immunother, 39, 127, 10.1007/BF01525318

Okamoto, 2001, Enhancement of anti-cancer immunity by lipoteichoic acid–related molecule isolated from a penicillin-killed group A Streptococcus, Cancer Immunol Immunother, 50, 408, 10.1007/s002620100207

Gorelik, 1994, Low-dose melpharan-induced shift in the production of a TH2-type cytokine to a TH1-type cytokine in mine bearing a large MOPC-315 tumor, Cancer Immunol Immunother, 39, 117, 10.1007/BF01525317

Takeuchi, 1997, TH2-like response and antitumor effect of anti–interleukin-4 mAb in mice bearing renal cell carcinoma, Cancer Immunol Immunother, 43, 375, 10.1007/s002620050347

Sakaguchi, 2004, Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses, Annu Rev Immunol, 22, 531, 10.1146/annurev.immunol.21.120601.141122

Wang, 2006, Regulatory T cells and Toll-like receptors in cancer therapy, Cancer Res, 66, 4987, 10.1158/0008-5472.CAN-05-4676

Li, 2010, Updates of adjuvant therapy in pancreatic cancer: where are we and where are we going? Highlights from the “2010 ASCO Annual Meeting.” Chicago, IL, USA. June 4–8, 2010, JOP, 11, 310

Miyazawa, 2010, Phase I clinical trial using peptide vaccine for human vascular endothelial growth factor receptor 2 in combination with gemcitabine for patients with advanced pancreatic cancer, Cancer Sci, 101, 433, 10.1111/j.1349-7006.2009.01416.x

Yanagimoto, 2007, Immunological evaluation of personalized peptide vaccination with gemcitabine for pancreatic cancer, Cancer Sci, 98, 605, 10.1111/j.1349-7006.2007.00429.x

Melief, 2008, Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines, Nat Rev Cancer, 8, 351, 10.1038/nrc2373

Bauer, 2007, Dendritic cell–based vaccination combined with gemcitabine increases survival in a murine pancreatic carcinoma model, Gut, 56, 1275, 10.1136/gut.2006.108621

Hirooka, 2009, A combination therapy of gemcitabine with immunotherapy for patients with inoperable locally advanced pancreatic cancer, Pancreas, 38, e69, 10.1097/MPA.0b013e318197a9e3

Keilholz, 2002, Immunologic monitoring of cancer vaccine therapy: results of a workshop sponsored by the Society for Biological Therapy, J Immunother, 25, 97, 10.1097/00002371-200203000-00001

Suzuki, 2007, Gemcitabine has significant immunomodulatory activity in murine tumor models independent of its cytotoxic effects, Cancer Biol Ther, 6, 880, 10.4161/cbt.6.6.4090

Suzuki, 2005, Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity, Clin Cancer Res, 11, 6713, 10.1158/1078-0432.CCR-05-0883

Yano, 2006, A new strategy using autologous dendritic cells and lymphokine-activated killer cells for cancer immunotherapy: efficient maturation of DCs by co-culture with LAK cells in vitro, Oncol Rep, 16, 147

Valteau-Couanet, 2002, Dendritic cells for NK/LAK activation: rationale for multicellular immunotherapy in neuroblastoma patients, Blood, 100, 2554, 10.1182/blood.V100.7.2554