Clinical and Genetic Findings in 28 American Cocker Spaniels with Aural Ceruminous Gland Hyperplasia and Ectasia

Angus, 2002, Breed variations in histologic features of chronic severe otitis externa in dogs: 80 cases (1995–2001), Journal of the American Veterinary Medical Association, 221, 1000, 10.2460/javma.2002.221.1000 Asher, 2009, Inherited defects in pedigree dogs. Part 1: disorders related to breed standards, The Veterinary Journal, 182, 402, 10.1016/j.tvjl.2009.08.033 August, 1988, Otitis externa: a disease of multifactorial etiology, Veterinary Clinics of North America: Small Animal Practice, 18, 731, 10.1016/S0195-5616(88)50076-1 Bannoehr, 2012, Staphylococcus pseudintermedius in the dog: taxonomy, diagnostics, ecology, epidemiology and pathology, Veterinary Dermatology, 23, 253, 10.1111/j.1365-3164.2012.01046.x Björnerfeldt, 2008, Assortative mating and fragmentation within dog breeds, Evolutionary Biology, 8, 28 Bradley, 2016, Longitudinal evaluation of the skin microbiome and association with microenvironment and treatment in canine atopic dermatitis, Journal of Investigative Dermatology, 136, 1182, 10.1016/j.jid.2016.01.023 Chang, 2015, Second-generation PLINK: rising to the challenge of larger and richer datasets, GigaScience, 4, 10.1186/s13742-015-0047-8 Chesney, 2002, Food sensitivity in the dog: a quantitative study, Journal of Small Animal Practice, 43, 203, 10.1111/j.1748-5827.2002.tb00058.x Coleman, 2016, Complication rates after bilateral versus unilateral total ear canal ablation with lateral bulla osteotomy for end-stage inflammatory eardisease in dogs: 79 ears, Veterinary Surgery, 45, 659, 10.1111/vsu.12505 Cruz, 2008, The legacy of domestication: accumulation of deleterious mutations in the dog, Molecular Biology and Evolution, 25, 2331, 10.1093/molbev/msn177 DeCandia, 2020, Ear mite infection is associated with altered microbial communities in genetically depauperate Santa Catalina Island foxes (Urocyon littoralis catalinae), Molecular Ecology, 29, 1463, 10.1111/mec.15325 Deng, 2013, Decreased expression of BTG3 was linked to carcinogenesis, aggressiveness and prognosis of ovarian carcinoma, Tumor Biology, 34, 2617, 10.1007/s13277-013-0811-2 Favrot, 2010, A prospective study of the clinical features of chronic canine atopic dermatitis and its diagnosis, Veterinary Dermatology, 21, 23, 10.1111/j.1365-3164.2009.00758.x Fernando, 1966, A histological and histochemical study of the gland of the external auditory canal of the dog, Research in Veterinary Science, 7, 116, 10.1016/S0034-5288(18)35063-X Firth, 1993, Bias reduction of maximum likelihood estimates, Biometrika, 80, 27, 10.1093/biomet/80.1.27 Fraser, 1961, The histopathology of the external auditory meatus of the dog, Journal of Comparative Pathology, 71, 253, 10.1016/S0368-1742(61)80031-3 Gough, 2018, Basic and clinical genetics, 1 Grönthal, 2015, Epidemiology of methicillin resistant Staphylococcus pseudintermedius in guide dogs in Finland, Acta Veterinaria Scandinavica, 57, 37, 10.1186/s13028-015-0129-8 Han, 2019, Identification of several key genes by microarray data analysis of bovine mammary gland epithelial cells challenged with Escherichia coli and Staphylococcus aureus, Gene, 683, 123, 10.1016/j.gene.2018.10.004 Harvey, 2001, Etiopathogenesis and classification of otitis externa, 82 Hillier, 2001, The ACVD task force on canine atopic dermatitis (I): incidence and prevalence, Veterinary Immunology and Immunopathology, 81, 147, 10.1016/S0165-2427(01)00296-3 Huang, 1994, Lipid content of cerumen from normal dogs and otitic canine ears, Veterinary Record, 134, 380, 10.1136/vr.134.15.380 Huang, 2009, Histological changes in the external ear canal of dogs with otitis externa, Veterinary Dermatology, 20, 422, 10.1111/j.1365-3164.2009.00853.x Kaimio, 2017, Survey of otitis externa in American cocker spaniels in Finland, Acta Veterinaria Scandinavica, 59, 14, 10.1186/s13028-017-0282-3 Lindblad-Toh, 2005, Genome sequence, comparative analysis and haplotype structure of the domestic dog, Nature, 438, 803, 10.1038/nature04338 Lloyd, 1982, Epidermal structure and topography of canine skin, Research in Veterinary Science, 33, 99, 10.1016/S0034-5288(18)32367-1 Mason, 1988, Total ear canal ablation combined with lateral bulla osteotomy for end-stage otitis in dogs – results in thirty dogs, Veterinary Surgery, 17, 263, 10.1111/j.1532-950X.1988.tb01012.x Matthiesen, 1990, Total ear canal ablation and lateral bulla osteotomy in 38 dogs, Journal of the American Animal Hospital Association, 26, 257 Miller, 2013, Diseases of eyelids, claws, anal sacs, and ears, 724 Moriarty, 2015, Ear mite removal in the Santa Catalina Island fox (Urocyon littoralis catalinae): controlling risk factors for cancer development, PloS One, 10, 10.1371/journal.pone.0144271 Nielsen, 1953, Glands of the canine skin – morphology and distribution, American Journal of Veterinary Research, 14, 448 Nilchian, 2018, CXADR-mediated formation of an AKT inhibited signalosome at tight junctions controls epithelial-mesenchymal plasticity in breast cancer, Cancer Research, 79, 47, 10.1158/0008-5472.CAN-18-1742 Niskanen, 2017, AncesTrim – a tool for trimming complex pedigrees, The Journal of Open Source Software, 2, 179, 10.21105/joss.00179 Nuttal, 2014, A pilot study to develop an objective clinical score for canine otitis externa, Veterinary Dermatology, 25 Ortiz-Zapater, 2017, CAR: a key regulator for adhesion and inflammation, The International Journal of Biochemistry & Cell Biology, 89, 1, 10.1016/j.biocel.2017.05.025 Picco, 2008, A prospective study on canine atopic dermatitis and food-induced allergic dermatitis in Switzerland, Veterinary Dermatology, 19, 150, 10.1111/j.1365-3164.2008.00669.x Rosser, 1993, Diagnosis of food allergy in dogs, Journal of the American Veterinary Medical Association, 203, 259 Saridomichelakis, 2007, Aetiology of canine otitis externa: a retrospective study of 100 cases, Veterinary Dermatology, 18, 341, 10.1111/j.1365-3164.2007.00619.x Schreiber, 2014, The IgCAMs CAR, BT-IgSF, and CLMB: structure and function, 21 Stout-Graham, 1990, Morphologic measurements of the external horizontal ear canal of dogs, American Journal of Veterinary Research, 51, 990 Van der Gaag, 1986, The pathology of the external ear canal in dogs and cats, Veterinary Quarterly, 4, 307, 10.1080/01652176.1986.9694061 Verdino, 2010, The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K, Science, 329, 1210, 10.1126/science.1187996 Vickers, 2015, Pathology and epidemiology of ceruminous gland tumors among endangered Santa Catalina Island foxes (Urocyon littoralis catalinae) in the Channel Islands, USA, PloS One, 10, 10.1371/journal.pone.0143211 White, 1990, Total ear canal ablation and lateral bulla osteotomy in the dog, Journal of Small Animal Practice, 31, 547, 10.1111/j.1748-5827.1990.tb00683.x Whitherden, 2010, The adhesion molecule JAML is a costimulatory receptor for epithelial γδ T cell activation, Science, 329, 1205, 10.1126/science.1192698 Zen, 2005, Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils, Molecular Biology of the Cell, 16, 2694, 10.1091/mbc.e05-01-0036 Zheng, 2017, The suppressing effects of BTG3 on aggressive behaviors and phenotypes of colorectal cancer: an in vitro and vivo study, Oncotarget, 8, 18322, 10.18632/oncotarget.15438 Zhou, 2012, Genome-wide efficient mixed-model analysis for association studies, Nature Genetics, 44, 821, 10.1038/ng.2310 Zur, 2011, The association between the signalment, common causes of canine otitis externa and pathogens, Journal of Small Animal Practice, 52, 254, 10.1111/j.1748-5827.2011.01058.x