Clinical and Biological Implications of the Tumor Microenvironment

Orr J (1938) Changes antecedent to tumour formation during the treatment of mouse skin with carcinogenic hydrocarbons. J Pathol Bacteriol 46:495–515

Tarin D (1972) Morphological studies on the mechanism of carcinogenesis. In: Tarin D (ed) Tissue interactions in carcinogenesis. Academic, London, pp 227–289

Tarin D (1972) Tissue interactions in morphogenesis, morphostasis and carcinogenesis. J Theor Biol 34(1):61–72

Kratochwil K (1972) Tissue interaction during embryonic development. In: Tarin D (ed) Tissue interactions in carcinogenesis. Academic, London, pp 1–47

Tarin D (1967) Sequential electron microscopical study of experimental mouse skin carcinogenesis. Int J Cancer 2(3):195–211

Tarin D (1969) Fine structure of murine mammary tumours: the relationship between epithelium and connective tissue in neoplasms induced by various agents. Br J Cancer 23(2):417–425

Billingham RE, Orr JW, Woodhouse DL (1951) Transplantation of skin components during chemical carcinogenesis with 20-methylcholanthrene. Br J Cancer 5(4):417–432

Orr J, Spencer A (1972) Transplantation studies of the role of the stroma in epidermal carcinogenesis. In: Tarin D (ed) Tissue Interactions in carcinogenesis. Academic, London, pp 291–303

Brand KG, Buoen LC, Johnson KH, Brand I (1975) Etiological factors, stages, and the role of the foreign body in foreign body tumorigenesis: a review. Cancer Res 35(2):279–286

Tarin D (1972) Tissue interactions in carcinogenesis. Academic, London

Folkman J (2006) Angiogenesis. Annu Rev Med 57:1–18

Tarin D (2011) Cell and tissue interactions in carcinogenesis and metastasis and their clinical significance. Semin Cancer Biol 21(2):72–82

Tarin D (2011) Inappropriate gene expression in human cancer and its far-reaching biological and clinical significance. Cancer Metastasis Rev

Spemann H (1938) Embryonic induction and development. In. Yale University Press, New Haven

Tarin D (1972) Tissue interactions and the maintenance of histological structure in adults. In: Tarin D (ed) Tissue interactions in carcinogenesis. Academic, London, pp 81–93

Warburton D, Wuenschell C, Flores-Delgado G, Anderson K (1998) Commitment and differentiation of lung cell lineages. Biochem Cell Biol 76(6):971–995

Beers MF, Morrisey EE (2011) The three R’s of lung health and disease: repair, remodeling, and regeneration. J Clin Invest 121(6):2065–2073

Saxén L (1972) Interactive mechanisms in morphogenesis. In: Tarin D (ed) Tissue interactions in carcinogenesis. Academic, London, pp 49–80

Nagatomo T, Ohga S, Takada H et al (2004) Microarray analysis of human milk cells: persistent high expression of osteopontin during the lactation period. Clin Exp Immunol 138(1):47–53

Nemir M, Bhattacharyya D, Li X, Singh K, Mukherjee AB, Mukherjee BB (2000) Targeted inhibition of osteopontin expression in the mammary gland causes abnormal morphogenesis and lactation deficiency. J Biol Chem 275(2):969–976

Kyriakides TR, Bornstein P (2003) Matricellular proteins as modulators of wound healing and the foreign body response. Thromb Haemost 90(6):986–992

Ehrchen J, Heuer H, Sigmund R, Schafer MK, Bauer K (2001) Expression and regulation of osteopontin and connective tissue growth factor transcripts in rat anterior pituitary. J Endocrinol 169(1):87–96

Tarin D, Matsumura Y (1993) Deranged activity of the CD44 gene and other loci as biomarkers for progression to metastatic malignancy. J Cell Biochem Suppl 17G:173–185

Weis SM, Cheresh DA (2011) Tumor angiogenesis: molecular pathways and therapeutic targets. Nat Med 17(11):1359–1370

Bornstein P, Sage EH (2002) Matricellular proteins: extracellular modulators of cell function. Curr Opin Cell Biol 14(5):608–616

Goodison S, Tarin D (1998) Clinical implications of anomalous CD44 gene expression in neoplasia. Front Biosci 3:e89–e109

Suzuki M, Mose E, Galloy C, Tarin D (2007) Osteopontin gene expression determines spontaneous metastatic performance of orthotopic human breast cancer xenografts. Am J Pathol 171(2):682–692

Lim PK, Bliss SA, Patel SA et al (2011) Gap junction-mediated import of microRNA from bone marrow stromal cells can elicit cell cycle quiescence in breast cancer cells. Cancer Res 71(5):1550–1560

Musumeci M, Coppola V, Addario A et al (2011) Control of tumor and microenvironment cross-talk by miR-15a and miR-16 in prostate cancer. Oncogene 30(41):4231–4242

Sugino T, Gorham H, Yoshida K et al (1996) Progressive loss of CD44 gene expression in invasive bladder cancer. Am J Pathol 149(3):873–882

Barnhill RL (2006) The Spitzoid lesion: rethinking Spitz tumors, atypical variants, ‘Spitzoid melanoma’ and risk assessment. Mod Pathol 19(Suppl 2):S21–S33

Esserman L, Shieh Y, Thompson I (2009) Rethinking screening for breast cancer and prostate cancer. JAMA 302(15):1685–1692

Sanders ME, Schuyler PA, Dupont WD, Page DL (2005) The natural history of low-grade ductal carcinoma in situ of the breast in women treated by biopsy only revealed over 30 years of long-term follow-up. Cancer 103(12):2481–2484

Nickerson HJ, Matthay KK, Seeger RC et al (2000) Favorable biology and outcome of stage IV-S neuroblastoma with supportive care or minimal therapy: a Children’s Cancer Group study. J Clin Oncol 18(3):477–486

Price JE, Carr D, Jones LD, Messer P, Tarin D (1982) Experimental analysis of factors affecting metastatic spread using naturally occurring tumours. Invasion Metastasis 2(2):77–112

Paget S (1889) The distribution of secondary growths in cancer of the breast. Lancet i:571–573

Tarin D, Price JE, Kettlewell MG, Souter RG, Vass AC, Crossley B (1984) Mechanisms of human tumor metastasis studied in patients with peritoneovenous shunts. Cancer Res 44(8):3584–3592

Tarin D, Price JE (1981) Influence of microenvironment and vascular anatomy on “metastatic” colonization potential of mammary tumors. Cancer Res 41(9 Pt 1):3604–3609

Hart IR, Fidler IJ (1980) Role of organ selectivity in the determination of metastatic patterns of B16 melanoma. Cancer Res 40(7):2281–2287

Suzuki M, Mose ES, Montel V, Tarin D (2006) Dormant cancer cells retrieved from metastasis-free organs regain tumorigenic and metastatic potency. Am J Pathol 169(2):673–681

Goodison S, Kawai K, Hihara J et al (2003) Prolonged dormancy and site-specific growth potential of cancer cells spontaneously disseminated from nonmetastatic breast tumors as revealed by labeling with green fluorescent protein. Clin Cancer Res 9(10 Pt 1):3808–3814

Tarin D (1976) Cellular interactions in neoplasia. In: Weiss L (ed) Fundamental aspects of metastasis. North Holland Publishing Co, Amsterdam, pp 151–187

Yasunaga M, Manabe S, Tarin D, Matsumura Y (2011) Cancer-stroma targeting therapy by cytotoxic immunoconjugate bound to the collagen 4 network in the tumor tissue. Bioconjug Chem 22(9):1776–1783

Horak E, Darling DL, Tarin D (1986) Analysis of organ-specific effects on metastatic tumor formation by studies in vitro. J Natl Cancer Inst 76(5):913–922

Nicolson GL, Dulski KM (1986) Organ specificity of metastatic tumor colonization is related to organ-selective growth properties of malignant cells. Int J Cancer 38(2):289–294

Attwood HD, Park WW (1961) Embolism to the lungs by trophoblast. J Obstet Gynaecol Br Commonw 68:611–617

Carstens PH (1969) Pulmonary bone marrow embolism following external cardiac massage. Acta Pathol Microbiol Scand 76(4):510–514

Grivennikov SI, Greten FR, Karin M (2010) Immunity, inflammation, and cancer. Cell 140(6):883–899

Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420(6917):860–867

Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646–674

Ekbom A, Helmick C, Zack M, Adami HO (1990) Ulcerative colitis and colorectal cancer. A population-based study. N Engl J Med 323(18):1228–1233

Kudo Y, Kamisawa T, Anjiki H, Takuma K, Egawa N (2011) Incidence of and risk factors for developing pancreatic cancer in patients with chronic pancreatitis. Hepatogastroenterology 58(106):609–611

Reid BJ, Weinstein WM (1987) Barrett’s esophagus and adenocarcinoma. Annu Rev Med 38:477–492

Balkwill F, Charles KA, Mantovani A (2005) Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 7(3):211–217

Mahmoud SM, Lee AH, Paish EC, Macmillan RD, Ellis IO, Green AR (2011) Tumour-infiltrating macrophages and clinical outcome in breast cancer. J Clin Pathol

Wyckoff JB, Wang Y, Lin EY et al (2007) Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res 67(6):2649–2656

Nash JR, Price JE, Tarin D (1981) Macrophage content and colony-forming potential in mouse mammary carcinomas. Br J Cancer 43(4):478–485

Shree T, Olson OC, Elie BT et al (2011) Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer. Genes Dev 25(23):2465–2479

Theoharides TC, Conti P (2004) Mast cells: the Jekyll and Hyde of tumor growth. Trends Immunol 25(5):235–241

Mahmoud SM, Paish EC, Powe DG et al (2011) Tumor-infiltrating CD8+ lymphocytes predict clinical outcome in breast cancer. J Clin Oncol 29(15):1949–1955

Mahmoud SM, Lee AH, Paish EC, Macmillan RD, Ellis IO, Green AR (2011) The prognostic significance of B lymphocytes in invasive carcinoma of the breast. Breast Cancer Res Treat

Mahmoud SM, Paish EC, Powe DG et al (2011) An evaluation of the clinical significance of FOXP3+ infiltrating cells in human breast cancer. Breast Cancer Res Treat 127(1):99–108

Talmadge JE (2011) Immune cell infiltration of primary and metastatic lesions: mechanisms and clinical impact. Semin Cancer Biol 21(2):131–138

Thiery JP (2002) Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2(6):442–454

Thiery JP, Acloque H, Huang RY, Nieto MA (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139(5):871–890

Hugo H, Ackland ML, Blick T et al (2007) Epithelial–mesenchymal and mesenchymal–epithelial transitions in carcinoma progression. J Cell Physiol 213(2):374–383

Tarin D, Thompson EW, Newgreen DF (2005) The fallacy of epithelial mesenchymal transition in neoplasia. Cancer Res 65(14):5996–6000, discussion -1

Tarin D (2011) Inappropriate gene expression in cancer and its far reaching clinical and biological significance. Canc Metastasis Rev

Domagala W, Wozniak L, Lasota J, Weber K, Osborn M (1990) Vimentin is preferentially expressed in high-grade ductal and medullary, but not in lobular breast carcinomas. Am J Pathol 137(5):1059–1064

Kubiak RS, Szadowska A (1997) Invasive lobular carcinoma of the breast: correlations between morphological features, vimentin expression, oestrogen receptor status and prognosis. Breast 6:89–96

Domagala W, Markiewski M, Kubiak R, Bartkowiak J, Osborn M (1993) Immunohistochemical profile of invasive lobular carcinoma of the breast: predominantly vimentin and p53 protein negative, cathepsin D and oestrogen receptor positive. Virchows Arch A Pathol Anat Histopathol 423(6):497–502

Slack NH, Bross ID (1975) The influence of site of metastasis on tumour growth and response to chemotherapy. Br J Cancer 32(1):78–86

Fidler IJ, Wilmanns C, Staroselsky A, Radinsky R, Dong Z, Fan D (1994) Modulation of tumor cell response to chemotherapy by the organ environment. Cancer Metastasis Rev 13(2):209–222

Hahn ME, Gianneschi NC (2011) Enzyme-directed assembly and manipulation of organic nanomaterials. Chem Commun (Camb) 47(43):11814–11821

US FaDA (2011) FDA Briefing document Oncology Drug [sic] Advisory Committee Meeting. December 5, 2007. BLA STN 125085/91.018. Avastin (bevacizumab). In

Pollack A (2011) F.D.A. Revokes approval of avastin for use as breast cancer drug. New York Times 2011 18th November, Sect. B1

Haines IE, Gabor Miklos G (2011) Time to mandate data release and independent audits for all clinical trials. Med J Aust 195(10):575–577

Patocs A, Zhang L, Xu Y et al (2007) Breast-cancer stromal cells with TP53 mutations and nodal metastases. N Engl J Med 357(25):2543–2551

Akino T, Hida K, Hida Y et al (2009) Cytogenetic abnormalities of tumor-associated endothelial cells in human malignant tumors. Am J Pathol 175(6):2657–2667

Sumida T, Kitadai Y, Shinagawa K et al (2011) Anti-stromal therapy with imatinib inhibits growth and metastasis of gastric carcinoma in an orthotopic nude mouse model. Int J Cancer 128(9):2050–2062